A5061616612- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Dementia and Cognitive Impairment Research
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- nanoparticles nucleation surface interactions
- Thermal properties of materials
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Iron Metabolism and Disorders
- Histone Deacetylase Inhibitors Research
- Biomedical Research and Pathophysiology
- Nutrition, Genetics, and Disease
- PI3K/AKT/mTOR signaling in cancer
- Nutritional Studies and Diet
- CRISPR and Genetic Engineering
- Metabolism, Diabetes, and Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Andrographolide Research and Applications
- Aging and Gerontology Research
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Nanoplatforms for cancer theranostics
Guangxi Medical University
2017-2024
National University of Singapore
2017
Daping Hospital
2006
Army Medical University
2006
The authors followed 5,437 people aged 55 years and older with normal baseline Mini-Mental State Examination score annually for 5 years. mean incidence of cognitive impairment was 2.3% per year. Cognitive activities in both the individual item (playing board games reading) composite measure were associated reduced risk impairment, while watching television an increased impairment.
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic disease cirrhosis. HCC now third leading cause cancer deaths worldwide, over 500,000 people affected. However, there no complete effective (ideal) treatment for yet, new methods are expected to be discovered. Herein, first time, we report anti-HCC effects copper-cysteamine nanoparticles (Cu-Cy NPs), type photosensitizers. An vitro 3-(4,5-dimethylthiazol-...
To assess the association between exposure to tobacco, heavy metals and phthalate on early pregnancy missed abortion.42 women with abortion 57 matched controls (women normal pregnancies) were recruited March May 2012, from Department of Gynecology Obstetrics, First Affiliated Hospital Guangxi Medical University People Zhuang Autonomous Region. The questionnaire survey was carried learn about basic conditions, as well smoking history all participants. levels metal, compared 2 groups by...
Abstract Background The response of hepatocellular carcinoma (HCC) to transarterial chemoembolization (TACE) treatment and its underlying mechanisms remain elusive. This study investigates the role enzymes involved in fatty acid activation, specifically Acyl-CoA synthetase long chain 4 (ACSL4), HCC patients treated with postoperative adjuvant TACE (PA-TACE) nutrient-deprived cells. Methods We examined expression ACSL4 family members clinical samples cell lines. significance ACSL4,...
Abstract Exosomes derived from hepatocellular carcinoma (HCC) cells are nanovesicles and involved in the occurrence development of HCC, they also serve as important carriers drug targets nanodrug delivery systems. The external shape internal structure exosomes indexes identification, isolated intact morphology is crucial to biological function integrity. However, given their susceptibility various influencing factors, HCC remain incompletely studied. In this study, purified were at different...
Mild cognitive impairment (MCI), as a transitional stage between normal aging and dementia, causes decline among one-fifth of elders aged 65 years older. Health-related lifestyles (HRL) are generally regarded modifiable influencing factors decline. The present study in vestigated how HRLs at two different life stages (one midlife the other later life) affect MCI occurrence community-dwelling elders, part Diet Healthy Aging (DaHA) Singapore. frequencies major HRL activities were compared 119...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, with a dismal 5-year survival rate less than 15%. The present study aimed to investigate whether AKT inhibition and glucose deprivation could synergistically kill HCC cells molecular mechanisms involved. were starved in deprivation, then resultant cell was determined by flow cytometry mitochondrial oxygen consumption rates using Seahorse XF-24 Extracellular Flux Analyzer. Glucose reduced for ATP...
AIM:To seek a new method for isolating and purifying exosomes from the supernatants of cultured human hepato cellular carcinoma cells.METHODS:Human hepatocellular cells SMMC-7721 were to adapt continuous serum-free culture,and culture collected.Exosomes derived isolated purified by improved ultracentrifugation.Transmission electron microscopy(TEM) was used observe morphology exosomes.Particle size detected with Nanosight technology.Western blot analysis examine CD63,CD9,and Alix exosomal...
Objective To investigate the combined effect and mechanism of metformin (Met) 2-deoxy-D-glucose (2DG) on cell proliferation apoptosis in liver cancer cells HepG2 Hep3B. Methods Wst-1 reagent was used to determine anti-proliferation effects after treatments with Met 2DG alone or Hep3B cells. Microscopy observe morphological changes Cell observed by flow cytometry treatment different kinds drugs. Western blotting analyze protein expressions Caspase-3, PARP, Mcl-1...