A5003133092- Breast Cancer Treatment Studies
- Pesticide Residue Analysis and Safety
- Insect and Pesticide Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pesticide and Herbicide Environmental Studies
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Immune cells in cancer
- Pituitary Gland Disorders and Treatments
- Chemokine receptors and signaling
- Lung Cancer Diagnosis and Treatment
- Shoulder Injury and Treatment
- RNA modifications and cancer
- Cancer Risks and Factors
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Global Cancer Incidence and Screening
- HER2/EGFR in Cancer Research
Jiujiang University
2025
Huazhong University of Science and Technology
2001-2025
Institute of Plant Protection
2011-2025
Peking University People's Hospital
2021-2025
Peking University
2021-2025
University of South China
2021-2025
Renji Hospital
2008-2025
Shanghai Jiao Tong University
2009-2025
Shihezi University
2025
Guangdong Medical College
2023-2025
The value of platinum-based adjuvant chemotherapy in patients with triple-negative breast cancer (TNBC) remains controversial, as does whether BRCA1 and BRCA2 (BRCA1/2) germline variants are associated platinum treatment sensitivity.To compare 6 cycles paclitaxel plus carboplatin (PCb) a standard-dose regimen 3 cyclophosphamide, epirubicin, fluorouracil followed by docetaxel (CEF-T).This phase randomized clinical trial was conducted at 9 centers hospitals China. Between July 1, 2011, April...
Abstract Background Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, is enriched in exosomes derived from platelet-rich plasma (PRP-Exos). However, the potential role PRP-Exos-S1P diabetic wound healing remains unclear. In this study, we investigated underlying mechanism angiogenesis repair. Methods Exosomes were isolated PRP by ultracentrifugation analysed transmission electron microscopy, nanoparticle tracking analysis western blotting. The...
Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. Little known about its invasion and metastasis mechanism so far.To identify the driver genes in GBC metastasis, we performed mRNA microarray of metastatic paired non-tumor samples, found PLEK2 was markedly upregulated tissues. Next, expression were examined larger cohort patients by qRT-PCR, western blot IHC staining. The clinicopathologic correlation determined statistical analyses. biological involvement...
Online learning environments demand learners to self-regulate their but many are poor at self-regulated (SRL). In this paper, two studies were conducted examine the effect of SRL supports, i.e., guiding goal setting and planning using an approach known as mental contrasting implementation intentions (MCII) prompting videos, on motivation in form task value self-efficacy, persistence, strategies, self-evaluation, self-satisfaction, student engagement, performance, attainment. Study 1, a...
Abstract Background tRNA-derived fragments (tRFs) have been shown to critical regulatory roles in cancer biology. However, the contributions of tRFs colorectal (CRC) remain largely unknown. Methods tRF3008A (a tRFRNA derived from tRNA Val ) was identified by RNA sequencing and validated quantitative reverse transcription PCR. The role CRC progression assessed both vitro vivo, its downstream target genes were cells. pull-down with mass spectrometry AGO-RIP used confirm interaction AGO...
Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors with variable recurrence rate. Currently, prediction unsatisfying and can be improved by understanding cellular origins differentiation status. Here, to comprehensively reveal origin PitNET, we perform comparative analysis single-cell RNA sequencing data from 3 anterior pituitary glands 21 PitNETs. We identify distinct genes representing major subtypes well poorly differentiated PitNETs in each lineage. To...
Abstract Ingestion of aged or irradiated apoptotic neutrophils actively suppresses stimulation macrophages (Mφ). Many bacterial pathogens can also provoke apoptosis in neutrophils, but little is known about how such cells influence Mφ activation. We found that undergoing induced by UV irradiation, Escherichia coli, Staphylococcus aureus could either stimulate inhibit In contrast to had ingested phagocytosed bacteria-induced exhibited markedly increased production the proinflammatory cytokine...
Abstract Gemcitabine is the first-line treatment for locally advanced and metastatic gallbladder cancer (GBC), but poor gemcitabine response universal. Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces gemcitabine-induced apoptosis in GBC cells P53-dependent manner through Elongator complex other uridine 34 (U ) tRNA-modifying enzymes. Mechanistically, impairs integrity stability abrogate wobble U tRNA modification, directly impedes modification-dependent...
Imidacloprid (IMI) is a typical neonicotinoid with the largest usage in agricultural orchards China. The long-term repeated use and lack of proper protective measures may result rural farmers people living near to be inevitably exposed IMI. Excessive exposure cause potential adverse effects on human health. To explore characteristics IMI urine, different groups people, including pesticide applicators their family members, kindergarten children IMI-applied were investigated. metabolite,...
Chronic inflammation-induced metastases have long been regarded as one of the significant obstacles in treating cancer. Tumor necrosis factor-α (TNF-α), a main inflammation mediator within tumor microenvironment, affects development by inducing multiple chemokines to establish complex network. Recent reports revealed that CXCL10/CXCR3 axis cancer cells invasiveness and metastases, Epithelial-mesenchymal transition (EMT) is reason for frequent proliferation distant organ colon (CC) cells,...
Imidaclothiz is a novel and systemic neonicotinoid pesticide with excellent insecticidal efficacy. However, knowledge of its uptake, translocation, biotransformation within plants still largely unknown, restricting work on accurate comprehensive risk assessment. Here, we systematically investigated the behavior imidaclothiz in three plant–water systems via hydroponic experiments. The results showed that was readily taken up by plant roots translocated upward, resulting relative enrichment...
To explore the prognostic value of albumin corrected anion gap (ACAG) within 24 hours admission to intensive care unit (ICU) for acute pancreatitis (AP).This was a retrospective cohort study. Adult AP patients admitted ICU from June 2016 December 2019 were included in study, who divided into three groups according initial serum ACAG upon admission: ≤ 14.87 mmol/L, < 19.03 and > mmol/L. The primary study outcome indicator in-hospital mortality. Age, sex, Glasgow Coma Scale score, Acute...