A5100444649- Histone Deacetylase Inhibitors Research
- Biochemical and Molecular Research
- Ubiquitin and proteasome pathways
- Mechanisms of cancer metastasis
- Gut microbiota and health
- Pineapple and bromelain studies
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Cell death mechanisms and regulation
- Signaling Pathways in Disease
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Retinal Development and Disorders
- Digestive system and related health
- Thyroid and Parathyroid Surgery
- Adipose Tissue and Metabolism
- Colorectal Cancer Treatments and Studies
- Growth and nutrition in plants
- Cardiovascular Function and Risk Factors
- Plant tissue culture and regeneration
- Ion Transport and Channel Regulation
- Pediatric health and respiratory diseases
- Enzyme Structure and Function
- Clostridium difficile and Clostridium perfringens research
Changchun University of Chinese Medicine
2024
Jiangsu University
2023
Fujian Agriculture and Forestry University
2023
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Second People’s Hospital of Huai’an
2020
Xuzhou Medical College
2020
Dalian University
2018
Dalian University of Technology
2018
National Center for Drug Screening
2014
Both neuroprotective and neurotoxic roles have previously been described for histone deacetylase-1 (HDAC1). Here we report that HDAC1 expression is elevated in vulnerable brain regions of two mouse models neurodegeneration, the R6/2 model Huntington disease Ca2+/calmodulin-dependent protein kinase (CaMK)/p25 double-transgenic tauopathic degeneration, suggesting a role promoting neuronal death. Indeed, elevating by ectopic promotes death otherwise healthy cerebellar granule neurons cortical...
Abstract HDAC4 is a Class II histone deacetylase (HDAC) that highly expressed in the brain, but whose functional significance brain not known. We show forced expression of cerebellar granule neurons protects them against low potassium‐induced apoptosis. also HT22 neuroblastoma cells from death induced by oxidative stress. HDAC4‐mediated neuroprotection does require its HDAC catalytic domain and cannot be inhibited chemical inhibitors HDACs. Neuroprotection Raf‐MEK‐ERK or PI‐3 kinase‐Akt...
Oxidative stress interferes with hepatic lipid metabolism at various levels ranging from benign storage to so-called second hit of inflammation activation. Isoquercitrin (IQ) is widely present flavonoid but its effects on remain unknown. We used free fatty acids (FFA) induced overload and oxidative model in two types liver cells measured cell viability, intracellular lipids, reactive oxygen species (ROS) within hepatocytes. In addition, Intracellular triglycerides (TG), superoxide dismutase...
Plants of the ginseng species have a long history with broad traditional applications, as these are recognized precious tonic herbal medicines since ancient times. More and more multiple chemical constituents pharmacological activities been confirmed discovered recently. Owing to its advantages, such intuitiveness, cheap, easy operate, high-throughput screening, zebrafish has become very popular model at present. Recently, toxicity tests, bio-activity evaluation, mechanism studies achieved...
Abstract Brahma‐related gene 1 (Brg‐1) is perceived as a cytoprotective protein due to its role in alleviating oxidative stress and apoptosis. Our study aimed explore the mechanism of Brg‐1 high glucose (HG)‐stimulated podocytes. The HG exposure downregulated inactivated kinase B (Akt) pathway Restoration inhibited HG‐induced viability reduction increase reactive oxygen species malondialdehyde levels decrease superoxide dismutase activity podocytes were reversed by overexpression....
To study the structure and diversity of gut microbiota in children with autism spectrum disorder (ASD), to predict metabolic function microbiota.Fecal samples were collected from 30 ASD (ASD group) 20 typically developing (TD) (TD group). Genomic DNA was extracted, 16S rDNA V4 region amplified by PCR, Illumina NovaSeq6000 platform used for high-throughput sequencing. The composition distribution characteristics analyzed two groups, predicted.There no significant differences alpha indices...
Thymidylate synthase (TYMS) is an essential enzyme for the de novo synthesis of dTMP and has been a primary target cancer chemotherapy. Although physical structure TYMS molecular mechanisms catalyzing conversion dUMP to have conducted thorough studies, oligomeric remains unclear. Here, we show that human not only exists in dimer but also octamer by intermolecular Cys43-disulfide formation. We optimize expression condition recombinant using Escherichia coli system. Using HPLC-MS/MS, purified...