A5058637204- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Bladder and Urothelial Cancer Treatments
- Advanced Proteomics Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Advanced biosensing and bioanalysis techniques
- Kidney Stones and Urolithiasis Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Urinary and Genital Oncology Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Infectious Diseases and Tuberculosis
- Biosensors and Analytical Detection
- Metabolomics and Mass Spectrometry Studies
- CRISPR and Genetic Engineering
- Microbial infections and disease research
- Pharmacogenetics and Drug Metabolism
- Meat and Animal Product Quality
- Immunodeficiency and Autoimmune Disorders
- Magnetism in coordination complexes
- Viral-associated cancers and disorders
- Ureteral procedures and complications
Nantong University
2022-2025
University of Electronic Science and Technology of China
2025
Beijing Children’s Hospital
2014-2024
Capital Medical University
2015-2024
Beijing Friendship Hospital
2013-2024
Beijing Municipal Education Commission
2024
Chengdu University
2018-2024
National Center for Women and Children’s Health, China CDC
2024
South China Normal University
2024
National Clinical Research
2024
OBJECTIVE: Our aim was to describe the patient characteristics, clinical–epidemiological profile, and treatment outcome of childhood tuberculosis (TB). METHODS: A retrospective, descriptive study undertaken 1212 children aged 0 18 years admitted Beijing Children’s Hospital for TB from January 2002 December 2010. Statistical significance category variables evaluated by using Fisher’s exact test. RESULTS: Fifty-four percent patients had extrapulmonary (EPTB), 38.8% tuberculous meningitis,...
To study the expression patterns of long noncoding RNA (lncRNA) colon cancer-associated transcript 1 (CCAT1) and changes in cell proliferation, apoptosis, migration invasion induced by silencing CCAT1 bladder cancer cells.The levels were determined using realtime quantitative polymerase chain reaction cancerous tissues paired normal from 34 patients with cancer. The relationship between clinical characteristics was analyzed. And then we conducted experiments. Bladder urothelial carcinoma...
ABSTRACT Mycobacterium tuberculosis can acquire resistance to rifampin (RIF) through mutations in the rpoB gene. This is usually accompanied by a fitness cost, which, however, be mitigated secondary rpoA or rpoC study aimed identify and clinical M. isolates northern China order clarify their role transmission of drug-resistant (TB). The collection included 332 RIF-resistant 178 RIF-susceptible isolates. majority belonged Beijing genotype (95.3%, 486/510 isolates), no mutation was found...
Abstract Objectives To explore the drug susceptibility of levofloxacin (LFX), moxifloxacin (MFX), bedaquiline (BDQ), linezolid (LZD), clofazimine (CFZ) and delamanid (DLM) against multidrug resistant tuberculosis (MDR-TB) isolates from resistance survey southwest China, to illustrate genetic characteristics MDR-TB with acquired resistance. Methods A total 339 strains were collected smear-positive TB patients in China between January 2014 December 2016. The MICs for above mentioned drugs...
Mycoplasma pneumoniae (MP) is a one of most common pathogen in causing respiratory infection children and adolescents. Rapid efficient diagnostic methods are crucial for control treatment MP infections. Herein, we present an operationally simple, rapid molecular method identification, which eliminates expensive instruments specialized personnel. The combines recombinase polymerase amplification (RPA) with clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated...
Abstract Benign prostatic hyperplasia (BPH) is the most common and progressive urological disease in elderly men worldwide. Epidemiological studies have suggested that speed of progression varies among individuals, while pathophysiological mechanisms accelerated clinical some BPH patients remain to be elucidated. In this study, we defined with as belonging group (transurethral resection prostate [TURP] surgery at ≤50 years old), normal-speed (TURP ≥70 or non-progressive (age old without...
Subtelomeric imbalance is widely accepted as related to developmental delay/mental retardation (DD/MR). Fine mapping of aberrations in gene-enriched subtelomeric regions provides essential clues for localizing critical regions, and a strategy identifying new candidate genes. To date, no large-scale study has been conducted on DD/MR patients mainland China. This included 451 Chinese children with moderate severe clinically unexplained DD/MR. The subtelomere-MLPA (multiplex ligation dependent...
Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having third highest global TB burden, no TB-related GWAS has been performed China. Here, we first three-stage on Han Chinese population. In stage 1 (discovery stage), after quality control, 691 388 SNPs present 972 patients and 1537 controls were retained. After replication an additional 3460 4862 (stages 2 3), identified three significant loci...
Multifaceted evidence has shown that psychiatric disorders share common neurobiological mechanisms. However, the tremendous inter-individual heterogeneity among patients with limits trans-diagnostic studies case-control designs, aimed at identifying clinically promising neuroimaging biomarkers. This study aims to identify neuroanatomical differential factors (ND factors) underlying gray matter volume variations in five disorders. We leverage 4 independent datasets of 878 diagnosed and 585...
Separation of monophosphopeptides from multi-phosphopeptides in complex biological samples is significant the study protein kinase signal transduction pathways. To best our knowledge, very few materials have been reported that could selectively enrich because chemical difficulty retaining intermediate and excluding both non-phosphopeptides acidic conditions, which requires unique interactions to balance metallic affinity hydrophobicity. With large surface area, abundant accessible active...
The whole seed of tartary buckwheat (Fagopyrum tataricum) is considered as a healthy and functional food, which rich in kinds flavonoids with potential antioxidant effect. An in-depth analysis (TBS) proteome was performed using shotgun proteomics strategy. Total protein TBS extracted digested, then the peptides were separated by offline two-dimensional liquid chromatography identified tandem mass spectrometry. 3,363 high-confidence proteins from 13,730 matched peptides, which, 2,499...
Since the onset of COVID-19 pandemic in 2020, global efforts towards tuberculosis (TB) control have encountered unprecedented challenges. There is an urgent demand for efficient and cost-effective diagnostic technologies TB. Recent advancements CRISPR-Cas improved our capacity to detect pathogens. The present study established a CRISPR-Cas12a-based multiplex detection (designated as MCMD) that simultaneously targets two conserved insertion sequences (IS6110 IS1081) Mycobacterium complex...
ObjectivesTo evaluate the diagnostic value of targeted next generation sequencing (tNGS) in childhood tuberculosis (TB) and compare accuracy with Xpert MTB/RIF method.MethodsChildren aged ≤18 years symptoms suggestive TB during July 2021 to December 2022 at Beijing Children's Hospital were included, performances tNGS evaluated.ResultsA total 103 children suspected recruited, including 72 discharge diagnosis 31 non-TB cases. The mean age was 7.37 ± 4.77 years, 62.1 % male. most common type...
Chemokine (C-C motif) ligand 2 CCL2/MCP-1 is among the key signaling molecules of innate immunity; in particular, it involved recruitment mononuclear and other cells response to infection, including tuberculosis (TB) essential for granuloma formation.We identified a tag SNP gene (rs4586 C/T). In order understand whether this may serve evaluate contribution CCL2 expression TB disease, we further analysed distribution its alleles genotypes 301 cases versus 338 non-infected controls (all BCG...
Atopic dermatitis (AD) is a chronic inflammatory pruritic skin disease in which the pathogenic mechanism complicated and not completely understood. Reports on role of regulated cells AD have recently evolved to regulate B cells, may play allergic inflammation as well. In present study, we examined frequency regulatory function CD5+CD19+CD1dhi B10 an AD-like mouse model. Our results showed that percentage increased while IL-10-producing CD19+B decreased mice group. Moreover, no difference...
OBJECTIVES:Xpert Mycobacterium tuberculosis and rifampicin (MTB/RIF) Ultra assay has increasingly been used in adult diagnosis, but data relating to its diagnostic accuracy children are lacking. Because a qualified sputum specimen is difficult obtain children, this study evaluated the value of childhood using bronchoalveolar lavage fluid.
Hydrothermal reactions of bis(benzimidazol-2-ylmethyl)imino(methylenephosphonic acid) {[(C(7)H(5)N(2))CH(2)]2NCH(2)PO(3)H(2), bbimpH2} with metal salts result in four new compounds, namely, Mn2{[(C(7)H(5)N(2))CH2]2NCH(2)PO(3)}2(H2O)2.2H2O (1), Cd2{[(C(7)H(5)N(2))CH2]2NCH(2)PO(3)}2.2H2O (2), Fe2{[(C(7)H(5)N(2))CH2]2NCH(2)PO(3)}2.H2O (3), and CuI(2){[(C(7)H(5)N(2))CH2]2NCH(2)P(OH)O2}2 (4). Compounds 1 2 have dinuclear structures which two {MN(3)O(3)} octahedra are linked through edge sharing....