A5101411072- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Viral-associated cancers and disorders
- Organ and Tissue Transplantation Research
- Cytomegalovirus and herpesvirus research
- Bladder and Urothelial Cancer Treatments
- Polyomavirus and related diseases
- Organ Donation and Transplantation
- Sleep and related disorders
- Renal and Vascular Pathologies
- Cancer-related molecular mechanisms research
- Transplantation: Methods and Outcomes
- Urinary and Genital Oncology Studies
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Restless Legs Syndrome Research
- Hepatitis C virus research
- Rabies epidemiology and control
- Neurological Complications and Syndromes
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Shanghai Children's Medical Center
2024
Shanghai Jiao Tong University
2024
Capital Medical University
2014-2023
Beijing Friendship Hospital
2013-2023
Beijing Chao-Yang Hospital
2022
May Institute
2016
Southern Medical University
2015
Zhejiang Cancer Hospital
2014
To study the expression patterns of long noncoding RNA (lncRNA) colon cancer-associated transcript 1 (CCAT1) and changes in cell proliferation, apoptosis, migration invasion induced by silencing CCAT1 bladder cancer cells.The levels were determined using realtime quantitative polymerase chain reaction cancerous tissues paired normal from 34 patients with cancer. The relationship between clinical characteristics was analyzed. And then we conducted experiments. Bladder urothelial carcinoma...
Ubiquitin-like with PHD and ring-finger domain 1 (UHRF1) binds to methylated promoters of tumor-suppressor genes suppresses gene expression by forming complexes DNA methyltransferases. Recent studies have shown that repression regulator G-protein signaling (RGS) 2 increases cancer cell growth. However, little is known about whether UHRF1 promotes bladder progression epigenetic silencing RGS2. Here, we show increased in lines most tissues as compared normal controls. overexpression...
Mutation of TSC (encoding tuberous sclerosis complex protein) and activation mammalian target rapamycin (mTOR) have been implicated in the pathogenesis several renal diseases, such as diabetic nephropathy polycystic kidney disease. However, role mTOR potassium excretion hyperkalemia is not known. We showed that mice with collecting-duct (CD)–specific ablation TSC1 (CDTsc1KO) had greater 1 (mTORC1) CD demonstrated features pseudohypoaldosteronism, including hyperkalemia, hyperaldosteronism,...
Cisplatin-based combination chemotherapy regimen is a reasonable alternative to cystectomy in advanced/metastatic bladder cancer, but acquisition of cisplatin resistance common patients with cancer. Previous studies showed that loss homeodomain-interacting protein kinase-2 (HIPK2) contributes cell proliferation and tumorigenesis. However, the role HIPK2 regulating chemoresistance cancer not fully understood. In present study, we found mRNA levels are significantly decreased...
The current study aimed to investigate the prevalence and risk factors of restless legs syndrome (RLS) in patients undergoing hemodialysis, as well mortality risks cardiovascular cerebrovascular events.A total 354 hemodialysis from four hospitals were enrolled. RLS was diagnosed using International Study Group (IRLSSG) criteria. evaluated face-to-face IRLSSG rating scale, Epworth Sleepiness Scale (ESS), Hamilton Anxiety Scale, Depression Pittsburgh Sleep Quality Index (PSQI). followed up for...
Wild-type p53-induced phosphatase (Wip1) is a member of the protein type 2C family and an established oncogene due to its dephosphorylation several tumor suppressors negative control DNA damage response system. It has been reported dephosphorylate p53, ataxia telangiectasia mutated, checkpoint kinase 1 p38 mitogen activated kinases, forming feedback loops inhibit apoptosis cell cycle arrest. Wip1 serves major role in tumorigenesis, progression, invasion, distant metastasis various types...
Due to the increasing number of DCD transplantations since 2015, transmission rabies through solid organ transplantation has become a notable problem in China and attracted attention public.
Renal ischemia/reperfusion injury (IRI) is a main risk factor for the occurrence of delayed graft function or primary nonfunction kidney transplantation. However, it lacks ideal molecular markers indicating IRI in The present study to explore novel candidate genes involved renal IRI. Experimental mouse models were constructed, and differentially expressed screened using microarray assay. Gene Ontology Kyoto Encyclopedia Genes Genomes enrichment analysis performed. expression was detected...
Chronic kidney disease (CKD) and end stage renal (ESRD) are not well characterized in prostate cancer patients. This study aimed to examine the clinical characteristics postsurgical outcomes of patients with or without CKD ESRD undergoing radical prostatectomy for cancer. population-based, retrospective used patient data from Nationwide Inpatient Sample, largest all-payer US inpatient care database. From 2005 2014, 136,790 male aged > 20 years diagnosed who received were included....
Ischemic stroke is a leading cause of death worldwide, yet therapies are limited. During periods ischemia following reperfusion in ischemic stroke, not only loss energy supply, but few other factors including mitochondrial dysfunction and oxidative stress also make vital contribution to neuronal injury. Here we synthesized steroid compound 5α-androst-3β,5,6β-triol by 3 steps starting from dehydroepiandrosterone examined its effect on function primary cultured cortical neurons exposed hypoxia...
This study aimed to explore depressive symptoms and associated factors among renal-transplant (RT) recipients in China. included 287 RT recipients. Data were collected from August November 2014 by utilizing demographic forms, namely, the Self-rating Depression Scale Multidimensional of Perceived Social Support. Descriptive statistics, Student's t test, Chi-square ANOVA, multiple linear regression used for data analysis. More than half presented symptoms. All four transplant period groups (≤5...
Renal ischemia/reperfusion (IR) injury is one of the most important risk factors for occurrence delayed graft function (DGF) after kidney transplantation; however, its mechanism remains not fully understood. In present study, we screened differentially expressed genes in a murine model renal IR by using high-throughput assays. We identified Corin as significantly downregulated among 2218 (≥2-fold, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Objectives: Our study aimed to investigate the correlations between radiomics-based assessment and outcomes, including positive aortic remodeling (PAR), reintervention for dissection at 1 year, overall survival, in patients with Type B (TBAD) who underwent thoracic endovascular repair (TEVAR). Methods: This was a single-center, retrospective, cohort study. The comprised 104 had undergone TEVAR of TBAD our institution January 2010 October 2022. We segmented preoperative computed tomography...
Long-term outcome of DAAs therapy in kidney transplant recipients was unknown. Thus, we aimed to evaluate it a Chinese cohort HCV-infected recipients. Single-center and retrospective study initiating an regimen between January 2015 December 2017 conducted. Totally 26 KTX were divided into three groups, including KTX-HD Group, DAA-KTX Group KTX-DAA Group. On-treatment response defined as target not detected within 12 weeks. SVR 48, 96 HCV-RNA negativity weeks after treatment cessation,...
Background Donor and recipient risk factors on graft function have been well characterized. The contribution of demographic factors, such as age, gender, other potential donor at the time transplantation a is much less understood. In this study, we analyzed effects etc., short-term long-term in kidney transplant recipients from living donor. Methods A total 335 donors their recipients, who had our center May 2004 to December 2009, were included. Serum creatinine level was used assessment...
Objective: The aim was to evaluate the effectiveness of computed tomography (CT)-guided fine-needle aspiration biopsy (FNAB) from Mandibular notch and under zygomatic arch for pathological diagnosis recurrence nasopharyngeal carcinoma (NPC) after radiotherapy (RT). Materials Methods: Between October 2007 December 2013, 48 patients with suspected recurrent NPC underwent CT-guided FNAB. A modified coaxial technique used in all cases, multiple samples were obtained histological studies....
Background Advances in transplantation immunology show that the balance between dendritic cells (DCs) and their subsets can maintain stable immune status induction of tolerance after transplantation. The aim this study was to investigate if DCs DC subpopulations recipient peripheral blood are effective diagnostic indicators acute rejection following kidney Methods Immunofluorescent flow cytometry used classify white (WBCs), levels mononuclear (including dominant subpopulations, plasmacytoid...
CD4(+) T cells can be converted to CD4(-)CD8(-) double negative (DN cells) under appropriate conditions, and IL-2 enhanced the conversion. Here, we investigated effect of on proliferation function DN in vitro vivo. were hyporesponsive when restimulated by mature dendritic (mDCs), completely restored their responsiveness vitro. In addition, increased resistance apoptosis profoundly inhibited CD4(+)CD25(-) effector triggered mDCs vitro, this suppression was further IL-2. Adoptively...
Long-term prognosis and risk factors of de novo upper tract urothelial carcinoma after renal transplantation were rarely studied. Thus, the aim this study was to investigate clinical features, factors, long-term transplantation, especially impact aristolochic acid on tumor, using a large sample.106 patients enrolled in retrospective study. The endpoints included overall survival, cancer-specific bladder or contralateral recurrence-free survival. Patients grouped according exposure. Survival...