A5101400374- Brucella: diagnosis, epidemiology, treatment
- Fibroblast Growth Factor Research
- Burkholderia infections and melioidosis
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Kruppel-like factors research
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Plant tissue culture and regeneration
- Horticultural and Viticultural Research
- Mycobacterium research and diagnosis
- Animal Virus Infections Studies
- Alkaloids: synthesis and pharmacology
- Lepidoptera: Biology and Taxonomy
- Zebrafish Biomedical Research Applications
- Atherosclerosis and Cardiovascular Diseases
- Industrial Vision Systems and Defect Detection
- Diabetes Management and Research
- Bioactive Natural Diterpenoids Research
- Congenital heart defects research
- Biochemical and Structural Characterization
University of Toronto
2016-2024
Nanjing Drum Tower Hospital
2024
Zhejiang Hospital
2017-2024
Nanjing University of Chinese Medicine
2024
China Medical University
2024
Jinzhou Medical University
2012-2023
Animal Science Research Institute
2022-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2022
China Animal Health and Epidemiology Center
2014-2022
Wenzhou Medical University
2012-2022
The signaling network of innate immunity in Drosophila is constructed by multiple evolutionarily conserved pathways, including the Toll- or Imd-regulated NF-κB and JNK pathways. p38 MAPK pathway stress responses, but its role host defense not fully understood. Here we show that also participates defense. In comparison with wild-type flies, sensitivity to microbial infection was slightly higher p38a mutant, significantly p38b unchanged p38c mutant. p38b;p38a double-mutant flies were...
// Lili Tian 1,* , Dachuan Shen 2,* Xiaodong Li 2 Xiu Shan 1 Xiaoqi Wang 3 Qiu Yan 4 and Jiwei Liu Department of Oncology, First Affiliated Hospital Dalian Medical University, Dalian, Liaoning Province, China Institute Cancer Stem Cell, Dermatology, Northwestern University Feinberg School Medicine, Chicago, Illinois, United States America Biochemistry Molecular Biology, Provincial Core Lab Glycobiology Glycoengineering, * These authors have contributed equally to this work Correspondence to:...
Abstract Understanding mechanisms underlying adipogenic differentiation may lead to the discovery of novel therapeutic targets for obesity. Wnt signalling pathway activation leads repressed while certain microRNAs regulate pre-adipocyte proliferation and differentiation. We show here that in mouse white adipose tissue, miR-17-5p level is elevated after high fat diet consumption. upregulates differentiation, as its over-expression increased inhibition 3T3-L1 The Tcf7l2 gene encodes a key...
Objective This study aimed to determine whether dietary curcumin intervention targets both white adipose tissue (WAT) inflammation and brown (BAT)‐mediated energy expenditure. Methods C57BL/6J mice were fed with a low‐fat diet, high‐fat diet (HFD), or HFD plus curcumin. In addition assessing the effect of on metabolic profiles, this assessed WAT macrophage infiltration composition inflammatory cytokine production. Metabolic cages applied for determining Raw264.7 (ATCC, Manassas, Virginia)...
Subtelomeric imbalance is widely accepted as related to developmental delay/mental retardation (DD/MR). Fine mapping of aberrations in gene-enriched subtelomeric regions provides essential clues for localizing critical regions, and a strategy identifying new candidate genes. To date, no large-scale study has been conducted on DD/MR patients mainland China. This included 451 Chinese children with moderate severe clinically unexplained DD/MR. The subtelomere-MLPA (multiplex ligation dependent...
Receptor interacting protein 3 (RIP3) is a kinase that plays key role in programmed necrosis. Despite the importance of RIP3-dependent necrosis many pathological processes, current knowledge on function RIP3 very limited. Here we present results proteome-wide analysis RIP3-regulated phosphorylation sites using cells from wildtype (RIP3(+/+)) and knockout (RIP3(-/-)) mice. Because activation requires stimulation by certain extracellular stimuli such as ligands death receptors or Toll-like...
We found previously that short-term curcumin gavage stimulated mouse hepatic fibroblast growth factor 21 (Fgf21) expression. Here we conducted mechanistic exploration and investigated the potential pathophysiological relevance on this regulation. Fgf21 stimulation was observed at messenger RNA protein levels in mice with daily for 4 or 8 days primary hepatocytes treatment. Using peroxisome proliferator-activated receptor α (PPARα) agonist antagonist, along luciferase reporter chromatin...
Abstract N6‐methyladenosine (m6A) modification and m6A‐related RNA‐binding proteins (RBPs) play vital roles in various aspects of circRNA metabolism. Hsa_circRNA_103820 is implicated the pathogenesis multiple cancers, including lung cancer (LC). Moreover, bioinformatics analysis has suggested that hsa_circRNA_103820 possesses potential peptide‐coding ability. Thus, we aimed to investigate function this study. Cell viability, apoptosis rate, migratory invasive abilities were assessed using...
Objective To investigate the role of curcumin in treatment lupus nephritis (LN) by inhibiting migration neutrophils and underlying mechanism involved. Methods Two mouse models, MRL/lpr mice R848-treated mice, were treated with 50 mg/kg intraperitoneal injection. H&E Masson staining used to estimate histopathological changes kidney. Immunofluorescence was assess deposition immune complexes. The expression inflammatory factors detected enzyme-linked immunosorbent assay (ELISA) real-time...
Ischemic stroke induces profound effects on the peripheral immune system, which may participate infectious complications. However, exact function and mechanism of reaction in development are not well-elucidated. Recently, several long non-coding RNAs (LncRNAs) reported to affect ischemic process, especially immunological response after stroke. In present study, we investigated profile LncRNAs human during transition from acute subacute stage, when state system changes activation systemic...
Tetramethyl bisphenol A (TMBPA) is a commonly used analog, as fire retardant. However, whether it inhibits the function of Leydig cells in late puberty remains unclear. In this study, 35-day-old male Sprague-Dawley rats were gavaged with 0, 10, 100, and 200 mg/kg body weight TMBPA for 21 days. significantly reduced serum testosterone levels at 10 higher doses without altering luteinizing hormone follicle-stimulating levels. increased iron concentraion while reducing ratio glutathione (GSH)...
Natural products are a rich resource for discovering innovational drugs. Herein, we isolated and characterized two compounds dihydroalterperylenol (DAP) alterperylenol (AP) from Alternaria sp. MG1, an endophytic fungus Vitis quinquangularis, investigated the underlying antitumor mechanism of AP. Mechanistically, AP inhibits growth HepG2 cells by targeting selenoprotein thioredoxin reductase (TrxR) ultimately induces cell apoptosis ferroptosis. Compared to DAP, α,β-unsaturated carbonyl...
The ubiquity of methicillin-resistant Staphylococcus aureus (MRSA) and the mounting prevalence antibiotic resistance necessitate identification novel therapeutic approaches to reduce selective pressure antibiotics. Targeting bacterial virulence factors, such as pivotal Sortase A (SrtA) in S. for adhesion invasion, salient toxin α-Hemolysin (Hla), offers a sophisticated approach attenuate pathogenicity without elimination. Herein, we report discovery flavonoid, isosakuranetin, which inhibits...
Endothelin 1 is a small peptide that involved in regulation of intraocular pressure and modulation ocular circulation. To investigate the role endothelin canine glaucoma, authors measured aqueous humor levels healthy dogs with hypertensive glaucoma.Aqueous samples were obtained general anesthesia from eyes (n = 5) glaucoma 10). Measurements made by enzyme immunoassay for 1.The range was 1.12 - 3.63 pg/mL 1.97 14.97 glaucomatous dogs. The (mean +/- SD) 2.33 0.90 8.11 5.03 pg/mL, respectively....
Oridonin, the major terpene found in Rabdosia rubescens (Henmsl.) Hara, is widely used as a dietary supplement and therapeutic drug. Oridonin has been proven to possess good anti-tumour activity, but little known about its effect on angiogenesis. The aim of this study was investigate antiangiogenic effects oridonin vivo vitro prove that activity based suppressing In vitro, antiangiogenesis studied by proliferation, apoptosis, migration, invasion, tube formation experiments human umbilical...
Viruses hijack host factors for their high speed protein synthesis, but information about these is largely unknown. In searching genes that are involved in viral replication, we carried out a forward genetic screen Drosophila mutants more resistant or sensitive to C virus (DCV) infection-caused death, and found virus-resistant line which the expression of pelo gene was deficient. Our mechanistic studies excluded resistance deficient flies resulting from known anti-viral pathways, revealed...
The bipartite transcription factor β-catenin (β-cat)/T cell (TCF), formed by free β-cat and a given TCF family member, serves as the effector of developmental Wnt signaling cascade. β-cat/TCFs also serve effectors certain peptide hormones or growth factors during adulthood. We reported that liver-specific expression dominant-negative Transcription 7 like 2 (TCF7L2DN) led to impaired glucose disposal. Here we show that, in this LTCFDN transgenic mouse model, serum hepatic lipid contents were...
The complete mitochondrial genome of Apatura ilia (GenBank accession no. JF437925) was determined as a circular DNA molecule 15 242 bp, with common genes 13 putative proteins, 2 rRNAs, and 22 tRNAs the same gene arrangement in other sequenced lepidopterans. All protein-coding had typical start codon ATN,except for COI’s using CGA its previously demonstrated lepidopteran species. comparison nucleotide sequences A. mitogenome ten Nymphalidae species showed nearly identical orientation...