A5100771835- Liver Disease Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Folate and B Vitamins Research
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Lipid metabolism and disorders
- Cholesterol and Lipid Metabolism
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Nutritional Studies and Diet
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Natural Antidiabetic Agents Studies
- Metabolomics and Mass Spectrometry Studies
- Alcohol Consumption and Health Effects
- Fatty Acid Research and Health
- Microbial Metabolism and Applications
- Coenzyme Q10 studies and effects
- Obesity, Physical Activity, Diet
- Cancer, Lipids, and Metabolism
- Cardiovascular Disease and Adiposity
Sun Yat-sen University
2016-2025
University Health Network
2024
University of Toronto
2012-2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Health Net
2024
Ningxia Medical University
2021-2023
Key Laboratory of Guangdong Province
2010-2022
Zhejiang Medicine (China)
2022
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020
Westlake University
2020
Many studies suggest that trimethylamine-N-oxide (TMAO), a gut-flora-dependent metabolite of choline, contributes to the risk cardiovascular diseases, but little is known for non-alcoholic fatty liver disease (NAFLD). We examined association circulating TMAO, choline and betaine with presence severity NAFLD in Chinese adults. performed hospital-based case-control study (CCS) cross-sectional (CSS). In CCS, we recruited 60 biopsy-proven cases 35 controls (18-60 years) determined serum...
Rationale: We and others have demonstrated that anthocyanins antiatherogenic capability. Because intact are absorbed very poorly, the low level of circulating parent may not fully account for their beneficial effect. found recently protocatechuic acid (PCA), a metabolite cyanidin-3 to 0-β-glucoside (Cy-3-G), has remarkable Objective: To investigate whether mouse gut microbiota metabolizes Cy-3-G into PCA determine how contributes potency its precursor, Cy-3-G. Methods Results: was determined...
Fruit wastes are one of the main sources municipal waste. In order to explore potential fruit as natural resources bioactive compounds, antioxidant potency and total phenolic contents (TPC) lipophilic hydrophilic components in (peel seed) 50 fruits were systematically evaluated. The results showed that different residues had diverse variation was very large. Furthermore, compounds identified quantified, catechin, cyanidin 3-glucoside, epicatechin, galangin, gallic acid, homogentisic...
Trimethylamine N-oxide (TMAO), the metabolite of choline generated by gut microbiota, is associated with nonalcoholic fatty liver disease (NAFLD) and could influence bile acid (BA) metabolism. However, whether TMAO aggravates steatosis modulating BA metabolism related mechanisms has not been investigated.A case-control study including biopsy-proven NAFLD patients (n = 34) controls 14) conducted to determine correlation between Serum levels total percentage farnesoid X receptor...
Background: Accumulating evidence has shown that disorders in the gut microbiota and derived metabolites affect development of atherosclerotic cardiovascular disease (ASCVD). However, which how specific microbial contribute to progression atherosclerosis clinical relevance their alterations remain unclear. Methods: We performed integrated microbiome–metabolome analysis 30 patients with coronary artery (CAD) age- sex-matched healthy controls identify CAD-associated metabolites, were then...
Anthocyanins, present in fruits and vegetables as natural colorants, have been well characterized to possess bioactive properties. Anthocyanin components extracted from black rice (Oryza sativa L. indica) separated by gel filtration identified using LC-MS were cyanidin 3-glucoside peonidin 3-glucoside. A standardized extract of pigmented fraction (BRE) containing known proportions exhibited marked antioxidant activities free radical scavenging capacities a battery vitro model systems....
BACKGROUND Anthocyanins have been shown to improve endothelial function in animal models. However, whether these compounds similar beneficial effects humans is largely unknown. METHODS In a short-term crossover study, 12 hypercholesterolemic individuals were given oral anthocyanins (320 mg) isolated from berries or placebo. Brachial artery flow-mediated dilation (FMD) was assessed before and after the intervention. long-term intervention trial (12 weeks), 150 mg/day, n = 75) placebo (n 75),...
Anthocyanins widely present in human diet and have a variety of health effects. This study investigates the anticancer effects an anthocyanin-rich extract from black rice (AEBR) on breast cancer cells vitro vivo. AEBR reduced viability cell lines MCF-7 (ER+, HER2/neu−), MDA-MB-231 (ER−, MDA-MB-453 HER2/neu+) induced apoptosis via intrinsic pathway by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP), depolarizing mitochondrial membrane potential, releasing cytochrome...
Polyphenols, including anthocyanins, from various plant foods are effective in the prevention of atherosclerosis animal and human studies. Protocatechuic acid (PCA), a major metabolite has been found to possess anti-carcinogenic effect, whereas vivo effect PCA as an anti-atherosclerotic agent remains unknown. We demonstrated herein that inhibited monocyte adhesion tumor necrosis factor-α (TNF-α)-activated mouse aortic endothelial cells, associated with inhibition vascular cell molecule 1...
Abstract Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has long been suspected in the pathogenesis of atherosclerosis; however, molecular mechanisms responsible for sustainment during atherosclerosis are poorly understood. Here we observe that subclinical endotoxemia, often seen humans with chronic inflammation, aggravates murine through programming into a state elevated Ly6C, CCR5, MCP-1 and reduced SR-B1. The is due to disruption homeostatic tolerance...
Edible macro-fungi are widely consumed as food sources for their flavors and culinary features. In order to explore the potential of a natural resource bioactive compounds, antioxidant properties polysaccharide contents 49 edible from China were evaluated systematically. A positive correlation between capacity total phenolic content indicated that compounds could be main contributors capacities these macro-fungi. Furthermore, many such gallic, homogentisic, protocatechuic, p-hydroxybenzoic...
Nicotinamide riboside (NR) is a nicotinamide adenine dinucleotide (NAD+) precursor which present in foods such as milk and beer. It was reported that NR can prevent obesity, increase longevity, promote liver regeneration. However, whether ethanol-induced injuries not known. This study aimed to explore the effect of on ethanol induced underlying mechanisms. We fed C57BL/6 J mice with Lieber-DeCarli liquid diet or without 400 mg/kg·bw for 16 days. Liver SirT1-PGC-1α-mitochondrial function were...