A5013552949- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Air Quality and Health Impacts
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Bioactive natural compounds
- Receptor Mechanisms and Signaling
- Prenatal Substance Exposure Effects
- Cannabis and Cannabinoid Research
- Genomics, phytochemicals, and oxidative stress
- Nanoparticles: synthesis and applications
- Heme Oxygenase-1 and Carbon Monoxide
- Orthopedic Infections and Treatments
- NF-κB Signaling Pathways
- melanin and skin pigmentation
- Skin Protection and Aging
- Magnolia and Illicium research
- Climate Change and Health Impacts
- Cell death mechanisms and regulation
- Fungal Biology and Applications
- Trace Elements in Health
- Sirtuins and Resveratrol in Medicine
- Colorectal Cancer Screening and Detection
- Acupuncture Treatment Research Studies
- Antimicrobial Resistance in Staphylococcus
Chang Gung University of Science and Technology
2017-2025
Universitätsklinikum Würzburg
2023-2025
Ming Chi University of Technology
2023
Chiayi Chang Gung Memorial Hospital
2019-2022
Chang Gung Memorial Hospital
2021-2022
GigaGen (United States)
2022
National Health Research Institutes
2010-2021
China Medical University
2013-2019
China Medical University Hospital
2013-2019
University of California, Davis
2018-2019
Abstract We explored the regulation of filaggrin, cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) expression induced by urban particulate matter (PM) in human keratinocytes. In addition, we investigated signaling pathways involved PM-induced effects on COX2/PGE2 filaggrin. PMs increases COX2 PGE2 production decreased filaggrin expression. These were attenuated pretreatment with inhibitor receptor antagonist, or after transfection siRNAs aryl hydrocarbon (AhR), gp91phox p47phox....
Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its potential effects on health remain unknown. The administration of polystyrene MPs (PS-MPs) to mice for eight weeks impaired learning and memory behavior. PS-MPs were detected in the brain especially hippocampus these mice. Concurrently, had decreased levels immediate-early genes, aberrantly enhanced synaptic glutamate AMPA receptors, elevated neuroinflammation, all which are critical plasticity memory....
Background: As lung cancer is the leading cause of death worldwide, development new medicines a crucial endeavor.Naringenin, flavanone derivative, possesses anti-cancer and anti-inflammatory properties has been reported to have cytotoxic effects on various cells.The current study investigated underlying molecular mechanism by which naringenin induces cell in cancer.Methods: The expression apoptosis, cycle arrest, autophagy markers H1299 A459 cells was evaluated using terminal...
Methadone and buprenorphine are widely used for treating people with opioid dependence, including pregnant women. Prenatal exposure to opioids has devastating effects on the development of human fetuses may induce long-term physical neurobehavioral changes during postnatal maturation. This study aimed at comparing behavioral outcomes young rats prenatally exposed buprenorphine, methadone, morphine. Pregnant Sprague-Dawley were administered saline, morphine, embryonic days 3-20. The cognitive...
Background: Lung cancer is a malignant tumor with metastatic potential.Chemokine ligand 14 (CXCL14) has been reported to be associated different cell migration and invasion.However, few studies have explored the function of CXCL14 its specific receptor in lung metastasis.This study aims determine mechanism CXCL14-promoted metastasis.Methods: The expression CXCL14, atypical chemokine 2 (ACKR2), epithelial mesenchymal transition (EMT) markers was evaluated by public database Cancer Genome...
// Ming-Horng Tsai 1, * , Ju-Fang Liu 2, Yao-Chang Chiang 3, 4 Stephen Chu-Sung Hu 5, 6 Lee-Fen Hsu 7 Yu-Ching Lin 7, 8, 9 Zih-Chan 10 Hui-Chun Lee 1 Mei-Chuan Chen 11 Chieh-Liang Huang 3 Chiang-Wen 4, 12, 13, 14 Department of Pediatrics, Division Neonatology and Pediatric Hematology/Oncology, Chang Gung Memorial Hospital, Yunlin, Taiwan 2 Central Laboratory, Shin-Kong Wu Ho-Su Taipei, Center for Drug Abuse Addiction, China Medical University University, Taichung, Nursing, Basic Sciences,...
Exposure to particulate matter (PM), a major form of air pollution, can induce oxidative stress and inflammation may lead many diseases in various organ systems including the skin. Eupafolin, flavonoid compound derived from Phyla nodiflora, has been previously shown exhibit pharmacological activities, antioxidant anti-inflammatory effects. Unfortunately, eupafolin is characterized by poor water solubility skin penetration, which limits its clinical applications. To address these issues, we...
A significant obstacle in guiding evidence-based management of bullous pemphigoid (BP) is the lack a standardised, validated scoring system for condition. The aim this study to evaluate suitability Bullous Pemphigoid Disease Area Index (BPDAI) and Autoimmune Skin disorder Intensity Score (ABSIS) as outcome measures BP clinical trials. Thirty-two patients were repeatedly assessed over four years using Physician Global Assessment (PGA), anti-BP180 ELISA titres, BPDAI, ABSIS, BPDAI-Pruritus,...
Periprosthetic joint infections (PJIs) have a high incidence of recurrence after total replacement and are difficult to treat by debridement or antibiotic treatment. Curcumin is natural product with anti-inflammatory anti-bacterial properties. The low bioactivity curcumin in water restricts its clinical application. nanoparticles (CURN) were developed overcome this limitation.In study, the therapeutic effects CURN their functions investigated Staphylococcus aureus biofilm-induced PJIs...
Osteosarcoma, a primary bone tumor, responds poorly to chemotherapy and radiation therapy in children young adults; hence, as the basis for an alternative treatment, this study investigated cytotoxic antiproliferative effects of naringenin on osteosarcoma cell lines, HOS U2OS, by using counting kit-8 colony formation assays. DNA fragmentation increase G2/M phase U2OS cells upon treatment with various concentrations were determined terminal deoxynucleotidyl transferase-mediated dUTP nick-end...
Abstract Background Olfactory epithelial stem cells hold significant potential for treating olfactory dysfunction by facilitating tissue maintenance and repair. Understanding the inherent qualities of these is crucial optimizing their therapeutic efficacy. Methods samples were collected from patients with deviated nasal septum (DNS) chronic rhinosinusitis (CRS). These cultured to form neurospheres (ONS), which then analyzed neural cell markers, neurotrophic factor production, ability...
Abstract Background Abuse of addictive substances is a serious problem that has significant impact on areas such as health, the economy, and public safety. Heroin use among young women reproductive age drawn much attention around world. However, there lack information effects prenatal exposure to opioids their offspring. In this study, an animal model was established study Methods Female pregnant Sprague-Dawley rats were sub-grouped receive (1) vehicle, (2) 2-4 mg/kg morphine (1 increment...
Abstract Heroin use among young women of reproductive age has drawn much attention around the world. However, there is lack information on long‐term effects prenatal exposure to opioids their offspring. Our previous study demonstrated that prenatally buprenorphine‐exposed offspring showed a marked change in cross‐tolerance morphine compared with other groups. In current study, this animal model was used methamphetamine ( METH )‐induced behavioral sensitization at adulthood. The results no...
Upregulation of intercellular adhesion molecule-1 (ICAM-1) involves adhesions between both circulating and resident leukocytes the human lung epithelial cells during inflammatory reactions. We have previously demonstrated that curcumin-loaded polyvinylpyrrolidone nanoparticles (CURN) improve anti-inflammatory anti-oxidative properties curcumin in hepatocytes. In this study, we focused on effects CURN expression ICAM-1 TNF-α-treated compared these to water preparation (CURH). TNF-αinduced...