A5018840163- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Pain Management and Opioid Use
- Cancer, Stress, Anesthesia, and Immune Response
- Ion channel regulation and function
- Opioid Use Disorder Treatment
- Pain Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience and Neuropharmacology Research
- Inflammatory mediators and NSAID effects
- Pharmacological Effects and Toxicity Studies
- Dementia and Cognitive Impairment Research
- Neuroscience and Neural Engineering
- Forensic Toxicology and Drug Analysis
- HER2/EGFR in Cancer Research
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Advanced X-ray Imaging Techniques
- Estrogen and related hormone effects
- X-ray Spectroscopy and Fluorescence Analysis
- Prenatal Substance Exposure Effects
- Atrial Fibrillation Management and Outcomes
- Pharmacological Receptor Mechanisms and Effects
- Neurosurgical Procedures and Complications
China Medical University
2013-2023
China Medical University Hospital
2013-2023
SLAC National Accelerator Laboratory
2015-2019
Bridge University
2016
Stanford University
2015
China Medical University
2013
National Health Research Institutes
2010-2011
Vollum Institute
2003-2007
Oregon Health & Science University
2003
Over the past decade, advances in grating-based soft X-ray spectrometers have revolutionized spectroscopies materials research. However, these novel are mostly dedicated designs, which cannot be easily adopted for applications with diverging demands. Here we present a versatile spectrometer design concept based on Hettrick-Underwood optical scheme that uses modular mechanical components. The spectrometer's optics chamber can used gratings operated either inside or outside orders, and...
Small conductance Ca2+-activated K+ channels (SK channels) are heteromeric complexes of pore-forming α subunits and constitutively bound calmodulin (CaM). The binding CaM is mediated in part by the electrostatic interaction between residues Arg-464 Lys-467 SK2 Glu-84 Glu-87 CaM. Heterologous expression double charge reversal SK2, R464E/K467E (SK2:64/67), did not yield detectable surface or channel activity whole cell inside-out patch recordings. Coexpression SK2:64/67 with wild type...
Article AbstractObjective: We investigated the relationship between antidepressant use and risk of subsequent dementia development.Method: A population-based retrospective case-control analysis was conducted using Taiwan National Health Insurance Research Database. From patients enrolled in program 2005 2011, we identified 2 subsets: 5,394 cases, who had major depression 1997-2004 subsequently were diagnosed with (ICD-9-CM code 290) 2005-2011, 5,232 controls, 2005-2011 but no history. The...
Abstract Background Abuse of addictive substances is a serious problem that has significant impact on areas such as health, the economy, and public safety. Heroin use among young women reproductive age drawn much attention around world. However, there lack information effects prenatal exposure to opioids their offspring. In this study, an animal model was established study Methods Female pregnant Sprague-Dawley rats were sub-grouped receive (1) vehicle, (2) 2-4 mg/kg morphine (1 increment...
Small conductance calcium-gated potassium (SK) channels share an overall topology with voltage-gated (K(v)) channels, but are distinct in that they gated solely by calcium (Ca(2+)), not voltage. For K(v) there is strong evidence for activation gate at the intracellular end of pore, which was revealed substituted cysteine accessibility homologous region SK2 channels. In this study, divalent ions cadmium (Cd(2+)) and barium (Ba(2+)), 2-aminoethyl methanethiosulfonate (MTSEA) were used to probe...
We utilize intense, single-cycle terahertz pulses to induce collective excitations in the charge-density-wave-ordered underdoped cuprate $\mathrm{YB}{\mathrm{a}}_{2}\mathrm{C}{\mathrm{u}}_{3}{\mathrm{O}}_{6+x}$. These manifest themselves as pronounced coherent oscillations of optical reflectivity transient state, accompanied by minimal incoherent quasiparticle relaxation dynamics. The occur at frequencies consistent with soft phonon energies associated charge-density-wave, but vanish above...
ObjectivesWe address the potential problem of stroke induced by morphine exposure comparing incidence in cancer patients treated with and without morphine.
This study investigated the relationship between depression and risk of subsequent venous thromboembolism (VTE) development.We conducted a population-based retrospective cohort analysis by using data for period 2000 to 2011 from Longitudinal Health Insurance Database Taiwan. A comprising 35,274 patients nondepression 70,548 matched according sex, age, index year with no history VTE were evaluated. Cox proportional hazard regression was used assess effects comorbidities, Kaplan-Meier method...
We attempted to examine the alterations elicited by opioids via coexpressed μ-opioid (MOP) and nociceptin/orphanin FQ (NOP) receptors for receptor localization Erk1/2 (p44/42 MAPK) in human embryonic kidney (HEK) 293 cells. Through two-photon microscopy, proximity of MOP NOP was verified fluorescence resonance energy transfer (FRET), morphine but not buprenorphine facilitated process MOP-NOP heterodimerization. Single-particle tracking (SPT) further revealed that or hindered movement...
We investigated the relationship between morphine treatment and risk of atrial fibrillation (AF) in female patients with breast cancer. identified a malignancy cohort 73,917 cancer without an AF history before date diagnosis 2000 2010 by using Longitudinal Health Insurance Database for Catastrophic Illness Patients Taiwan. This was divided into comparison cohorts comprising 18,671 55,246 patients, respectively, incidences newly diagnosed were calculated. used Cox proportional hazard model...
Methadone and buprenorphine are used in maintenance therapy for heroin addicts. In this study, we compared their effects on adenylate cyclase (AC) activity human embryonic kidney (HEK) 293 cells stably overexpressing μ-opioid receptor (MOR) nociceptin/opioid receptor-like 1 (ORL1) simultaneously. After acute exposure, methadone inhibited AC activity; however, induced compromised inhibition. When naloxone was introduced after 30 min incubation with methadone, the enhanced. This not observed...
Opioids are widely prescribed pain relievers with multiple side effects and potential complications. They produce analgesia via G-protein-protein coupled receptors: μ-, δ-, κ-opioid opioid receptor-like 1 receptors. Bivalent ligands targeted to the oligomerized receptors might be key developing analgesics without undesired obtaining effective treatment for addicts. In this review we will update biological of μ-opioids on homo- or hetero-oligomerized μ-opioid receptor discuss mechanisms...
Abstract Objectives This study investigates the relationship between current morphine use and risk of pulmonary embolism ( PE ) development in deep vein thrombosis DVT patients. Methods We conducted a population‐based nested case‐control retrospective analysis using L ongitudinal H ealth I nsurance D atabase 2000 T aiwan. A cohort 3668 patients with no history from 1998 to 2010 other 174 who subsequently developed were evaluated. Morphine was designated as ‘current’ if prescription duration...
Amphetamine use is a risk factor for psychosis, which imposes substantial burden on society. We aimed to investigate the incidence of psychosis associated with illicit amphetamine and whether rehabilitation treatments could influence risk.A retrospective cohort study was conducted using population based Taiwan Illicit Drug Issue Database (TIDID) National Health Insurance Research (NHIRD), from 2007 2016. identified 74 601 users as 2 98 404 subjects non-amphetamine cohort. The rate newly...
Objectives Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, and sepsis frequent cause of death in hospitalised patients. We investigated the relationship between ALS subsequent risk sepsis. Design A retrospective cohort analysis. Setting Patients with ALSs diagnosed 2000 2010 Taiwan National Health Insurance Research Database. Participants included 701 2804 patients as non-ALS groups, respectively. Outcome measures The was calculated by Cox proportional hazards...
Abstract Buprenorphine, a maintenance drug for heroin addicts, exerts its pharmacological function via κ‐ ( KOP ), μ‐opioid MOP ) and nociceptin/opioid receptor‐like 1 NOP receptors. Previously, we investigated effects in an vitro model expressing human receptors individually or simultaneously , + embryonic kidney 293 cells. Here, expanded this cell by ). Radioligand binding with tritium‐labelled diprenorphine confirmed the expression of Immunoblotting immunocytochemistry indicated that...
Introduction Patients with depressive disorder demonstrate rest–activity rhythm disturbances and cognitive function impairment. This study examined the association of individual changes over time mood symptoms attention. Methods We recruited 15 adult outpatients a diagnosis major from single medical center observed them for 12 months. Weekly parameters, including characteristics generated nonparametric circadian analysis, were retrieved actigraphy data. Attention was evaluated weekly...