A5015389016- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Lung Cancer Treatments and Mutations
- Respiratory and Cough-Related Research
- EEG and Brain-Computer Interfaces
- Neurological and metabolic disorders
- Trauma Management and Diagnosis
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- Allergic Rhinitis and Sensitization
- Fungal Infections and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Adrenal Hormones and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Infectious Diseases and Mycology
China Medical University
2013-2024
China Medical University Hospital
2013-2024
Massachusetts General Hospital
2024
Harvard University
2024
Translational Research Institute
2021
Observational & Pragmatic Research Institute
2021
Asia University
2017
Geisinger Health System
2016
Center for Clinical Research (United States)
2015-2016
China Medical University
2007-2015
Objectives: To determine the prevalence of COPD in Taiwan and to document disease characteristics associated risk factors. Methods: We conducted a random cross-sectional national survey adults older than 40 years Taiwan. Respiratory health screening questions identified subjects with diagnosed or whose reported symptoms also fulfilled an epidemiological case definition; these were eligible complete survey, which included indices symptom severity disability on comorbidities, medical...
The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) proposed a new severity assessment system emphasizing clinical symptom evaluation by COPD Assessment Test (CAT) or modified Medical Research Council (mMRC) dyspnea scores. aim of the study was to evaluate effectiveness two scoring systems in evaluating patients. A population based cross-sectional employing computer-assisted telephone interviewing (CATI) surveying epidemiology Taiwan. Among 6600 subjects recruited (age >...
Background Smoking is a known risk factor for obstructive sleep apnea (OSA). However, the specific pathological mechanism linking smoking to OSA remains unclear. This study aims explore endotypic traits of among current and former smokers. Methods We prospectively collected polysomnographic data from 980 patients with an apnea-hypopnea index (AHI)≥15 h −1 single clinical center. status was determined through self-reported questionnaires completed prior polysomnography. Endotypic...
Abstract Study Objectives Obstructive sleep apnea (OSA) is more prevalent in men and older adults. Few studies have explored variations pathological endotypic traits by age sex using a large patient sample, offering insights into the development of disease. Our study aims to examine how endotype characteristics OSA vary across ages different sex. Methods A cross-sectional was conducted, enrolling 2296 adult patients referred for in-laboratory diagnostic polysomnography at single center...
The efficacy and safety of indacaterol, a novel inhaled once daily ultra long-acting β(2) -agonist was evaluated in COPD patients six Asian countries/areas. This study primarily designed to obtain the regulatory approval indacaterol Japan.Moderate-to-severe were randomized 150 µg, 300 µg or placebo daily. Efficacy variables: trough FEV(1) (average 23 h 10 min 45 post-dose values), health status (St. George's Respiratory Questionnaire) transition dyspnoea index at week 12. Safety/tolerability...
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent upper airway obstruction during sleep. Despite the availability of continuous positive pressure (CPAP) as gold standard treatment, it not well tolerated all patients. Accordingly, research has increasingly focused on developing methods for OSA endotyping, which aims to identify underlying pathophysiological mechanisms help guide treatment CPAP-intolerant individuals. Four key endotypic traits have been identified,...
Abstract We aimed to evaluate whether polymorphisms of the interleukin‐4 (IL‐4) gene promoter and intron 3 regions, IL‐1 beta exon 5 regions are associated with oral cancer. This study included 130 patients cancer 105 age‐matched healthy controls who lived in same area as patients. Each genetic polymorphism was typed by polymerase chain reaction (PCR)‐based restriction analysis. then compared genotype distribution allelic frequencies each between controls. The CC homozygote IL‐4 −590 region...
Obstructive sleep apnea (OSA) is a heterogeneous syndrome with various endotypic traits and symptoms. A link among symptoms, endotypes, disease prognosis has been proposed but remains unsupported by empirical data.
Summary Determining the endotypes of obstructive sleep apnea (OSA) has potential implications for precision interventions. Here we assessed whether continuous positive airway pressure (CPAP) treatment outcomes differ across endotypic subgroups. We conducted a retrospective analysis data obtained from 225 patients with moderate‐to‐severe OSA single centre. Polysomnographic and CPAP titration study were collected between May 2020 January 2022. One‐month adherence was followed. Obstructive...
Background Over half of all cases obstructive sleep apnoea (OSA) are classified as supine-related OSA; however, the pathological endotype during supine position is not fully understood. This study aims to investigate endotypic traits supine-predominant OSA and explore variations in between lateral positions. Methods We prospectively recruited 689 adult patients with from a single centre April 2020 December 2022. Endotypic traits, namely arousal threshold, collapsibility, loop gain upper...
Background: Nasal polyposis (NP) is a chronic inflammatory disease of upper airway with unknown etiology. NP frequently associated asthma; the interaction between these comorbidities remains interesting. Oxidative stress has been implicated in pathophysiology and asthma. The aim this study to investigate significance oxidative sinonasal microenvironments by evaluating its association clinopathological parameters impacts on pathogenesis bronchial hyperresponsiveness (BHR) NP. Methods: Polyp...
Extensive use of continuous positive airway pressure (CPAP) has clinical benefits for most patients with obstructive sleep apnea (OSA). However, patient adherence is a major limiting factor to the effectiveness CPAP treatment. This study determined potential and quantifiable factors affecting willingness OSA undertake treatment by comparing polysomnographic parameters recorded during diagnosis titration. Patients moderate severe who attended diagnostic polysomnography (PSG) titration at...
Background and objectives: COPD obstructive sleep apnea (OSA) share similar pathological processes cardiovascular sequelae. Coexisting OSA in – “overlap syndrome” has worse prognosis than either condition alone, appropriate treatment improves survival. Our objectives were to ascertain the frequency at which coexists with risk of Taiwan compare factors, symptoms, life quality metrics between subgroups versus without OSA. Methods: We conducted a random cross-sectional national telephone survey...
Asthma is an airway hyperresponsive disease characterized by the expression of multiple inflammatory genes, including cytokines. Interleukin-I and interleukin-10 (IL-1 IL-10) are cytokines that might play a role in process inflammation therefore considered to be involved pathogenesis bronchial asthma. The aim this study was test whether polymorphisms promoter region exon 5 IL-1 gene, intron 2 IL-1Ra -627 nucleotide (C/A) IL-10 gene could genetic markers for susceptibility A normal control...
Sleep disordered breathing (SDB) is highly prevalent and may be linked to cardiovascular disease in a bidirectional manner. The Taiwan Society of Cardiology, Medicine Pulmonary Critical Care established task force experts evaluate the evidence regarding assessment management SDB patients with atrial fibrillation (AF), hypertension heart failure reduced ejection fraction (HFrEF). GRADE process was used assess associated 15 formulated questions. developed recommendations determined strength...
Sleep-related hypoventilation disorder (SHD) is common among obese patients with obstructive sleep apnea (OSA), but the pathological endotypes associated obesity and SHD remain unclear. To investigate relationship between body mass index (BMI) OSA, to explore endotypic traits of comorbid SHD. We prospectively collected polysomnographic studies 1364 overnight transcutaneous CO2 (TcCO2) measurements 420 patients. Endotypic were estimated using signals. was determined TcCO2 >55 mm Hg for ≥ 10...
Abstract Lung cancer, a common malignancy in Taiwan, involves multiple factors, including genetics and environmental factors. The survival time is very short once cancer diagnosed as being advanced stage surgically unresectable. Therefore, good model of prediction disease outcome important for treatment plan. We investigated the lung by using computer science from genetic polymorphism p21 p53 genes conjunction with patients' general data. studied 75 surgical unresectable patients. was made...
Abstract Introduction Patients with chronic obstructive pulmonary disease (COPD) frequently experience concurrent comorbidities; therefore, risk assessment for major adverse cardiovascular events (MACEs) is very important. Objectives We explored the association between COPD and of MACEs three common clinical events: acute myocardial infarction (AMI), ischemic stroke (IS), death (CVD). Methods evaluated predictive value CHA2DS2‐VASc score (congestive heart failure [C], hypertension [H], age...