A5028918398- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- HIV Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traditional Chinese Medicine Studies
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- Ginseng Biological Effects and Applications
- Growth Hormone and Insulin-like Growth Factors
- Bone health and osteoporosis research
- HIV/AIDS drug development and treatment
- Asthma and respiratory diseases
- Cancer Genomics and Diagnostics
- Muscle Physiology and Disorders
- Insect symbiosis and bacterial influences
- Biochemical Analysis and Sensing Techniques
- Cell Adhesion Molecules Research
- Hip and Femur Fractures
- Cancer-related molecular mechanisms research
- Mast cells and histamine
- Viral Infections and Vectors
- Cancer-related gene regulation
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
China Medical University
2015-2024
China Medical University Hospital
2014-2024
China Medical University
2018-2023
Keio University Hospital
2023
Taipei Medical University
2022
Chang Gung University
2019
National Yang Ming Chiao Tung University
2018
National Taiwan University
2017
Chinese Culture University
2012
National Tsing Hua University
2003-2005
Over the years, restorative benefits of natural environment have been taken seriously. These effects continue to be verified in research from both psychological and physiological perspectives. The latest functional magnetic resonance imaging (fMRI) technology provides an opportunity further explore psychophysiological aspects these environment. This study aimed compare value four types landscape environments (urban, mountain, forest, water) through questionnaires by investigating...
Abstract Background Idiopathic membranous nephropathy (IMN) is one of the most common forms autoimmune nephritic syndrome in adults. The purpose this study to evaluate whether polymorphisms PLA2R1 affect development IMN. Methods Taiwanese-Chinese individuals (129 patients with IMN and 106 healthy controls) were enrolled study. selected single nucleotide (SNPs) genotyped by real-time polymerase chain reaction using TaqMan fluorescent probes, further confirmed reaction-restriction fragment...
Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives rhubarb root on human cancer cells. Of 7 derivatives, only rhein showed antiproliferative apoptotic both HER2-overexpressing MCF-7 (MCF-7/HER2) control vector (MCF-7/VEC) Rhein induced dose- time-dependent manners increase in caspase-9-mediated apoptosis correlating activation...
Chinese herbal medicines (CHMs) are a resource of natural compounds (ingredients) and their potential chemical derivatives with anticancer properties, some which already in clinical use. Bei-Mu (BM), Jie-Geng (JG), Mai-Men-Dong-Tang (MMDT) important CHMs prescribed for patients lung cancer that have improved the survival rate.The aim this study was to systemically investigate mechanisms action these CHM products cells.We used network pharmacology approach product-related targets. In...
Abstract Background Height is an important anthropometric measurement and associated with many health-related outcomes. Genome-wide association studies (GWASs) have identified hundreds of genetic loci height, mainly in individuals European ancestry. Methods We performed genome-wide analyses replicated previously reported GWAS-determined single nucleotide polymorphisms (SNPs) the Taiwanese Han population (Taiwan Biobank; n = 67,452). A instrument composed 251 SNPs was selected from our GWAS,...
ABSTRACT Epstein-Barr virus (EBV) BBLF1 shares 13 to 15% amino acid sequence identities with the herpes simplex 1 UL11 and cytomegalovirus UL99 tegument proteins, which are involved in final envelopment during viral maturation. This study demonstrates that is a myristoylated palmitoylated protein, as UL99. Myristoylation of both facilitates its membrane anchoring stabilizes it. shown localize trans -Golgi network (TGN) along gp350/220, site where EBV particles takes place. The localization...
Cytolethal distending toxin (CDT) produced by Campylobacter jejuni comprises a heterotrimeric complex formed CdtA, CdtB, and CdtC. Among these subunits, CdtA CdtC function as essential proteins that mediate binding to cytoplasmic membranes followed delivery of CdtB into the nucleus. The CdtA/CdtC cell surface is mediated cholesterol, major component in lipid rafts. Although putative cholesterol recognition/interaction amino acid consensus (CRAC) domain CDT has been reported from several...
Nasopharyngeal carcinoma (NPC) is a head and neck cancer involving epithelial squamous-cell of the nasopharynx that mainly occurs in individuals from East Southeast Asia. We investigated whether Chinese herbal medicine (CHM) as complementary therapy offers benefits to these patients. retrospectively evaluated Taiwan Cancer Registry (Long Form) database for patients with advanced NPC, using or not CHM, between 2007–2013. Cox proportional-hazard model Kaplan‒Meier survival analyses were...
Virus isolation and antibody detection are routinely used for diagnosis of Japanese encephalitis virus (JEV) infection, but the low level transient viremia in some JE patients makes JEV from clinical surveillance samples very difficult. We describe use gold nanoparticle-based RT-PCR real-time quantitative assays its RNA genome. tested effect nanoparticles on four different PCR systems, including conventional PCR, reverse-transcription (RT-PCR), SYBR green acute phase infection. Gold...
Parkinson's disease (PD) is characterized by progressive neuronal cell loss and decline in movement. Recently, much attention has been focused on the dopaminergic neurotoxicity, which causes neurogeneration nervous system, thus implicating dysfunction predisposition to PD pathogenesis. β-glucosidase (GBA), enzyme deficient Gaucher's disease, cited as linked with disease. We investigated whether GBA mutation associated patients middle Taiwan. was detected polymerase chain reaction sequencing...
Background Bone morphogenetic protein receptor I B (BMPR1B) is a transmembrane mediating TGF-β signal transduction. Recent studies indicate tumor suppressor role for BMPR1B in ovarian cancer. Polymorphism at 3′UTR within the miR-125b binding site alters its affinity toward miRNA, which may result insufficient post-transcriptional repression. Methods Single-nucleotide polymorphisms rs1970801, rs1434536, and rs11097457 near were genotyped by Taqman assay on 193 endometriosis patients 202...
Human height can be described as a classical and inherited trait model. Genome-wide association studies (GWAS) have revealed susceptible loci provided insights into the polygenic nature of human height. Familial short stature (FSS) represents suitable for investigating genetics because disease associations with been ruled out in this case. In addition, FSS is caused only by genetically factors. study, we explored correlations risk genetic associated previous GWAS, alone cumulatively. We...
Severe acute respiratory syndrome coronavirus (SARS-CoV) proteins including ORF6 inhibit Type I interferon (IFN) signaling.This study identified SARS-CoV ORF6-interacting using the phage displayed human lung cDNA libraries, and examined association of ORF6-host factor interaction with IFN antagonism. After fifth round biopanning Escherichia coli-synthesized ORF6-His tagged protein, relative binding affinity clones to was determined direct enzyme-linked immunosorbent assay.The highest clone...
ABSTRACT The formation of the flavivirus prM-E complex is an important step for biogenesis immature virions, which followed by a subsequent cleavage prM to M protein through cellular protease result in production and release mature virions. In this study, intracellular Japanese encephalitis virus was investigated baculovirus coexpression E trans Sf9 insect cells as analyzed anti-E antibody immunoprecipitation sucrose gradient sedimentation analysis. A series carboxyl-terminally truncated...
Abstract Context Human height is an inheritable, polygenic trait under complex and multilocus genetic regulation. Familial short stature (FSS; also called stature) the most common type of insufficiently known. Objective To investigate FSS profile develop a risk predisposition score for prediction. Design Setting The participant group Han Chinese ancestry was diagnosed by pediatric endocrinologists in Taiwan. Patients Interventions profiles 1163 participants with were identified using...
Abstract The interaction between prM and E proteins in flavivirus-infected cells is a major driving force for the assembly of flavivirus particles. We used site-directed mutagenesis to study potential role transmembrane domains Japanese encephalitis virus (JEV) prM-E heterodimerization as well subviral particle formation. Alanine insertion scanning within GXXXG motif first segment JEV protein affected heterodimerization; its specificity was confirmed by replacing two glycines with alanine,...
Objective We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 rs2227983) among Taiwanese population. This present study aimed to elucidate whether can alter expression EGFR in progression RA. Methods The cohort included 366 Taiwan's Han Chinese RA patients 326 age gender matched healthy controls. Blood samples collected from participants were analyzed determine their serum levels identify...
Abstract STUDY QUESTION Are there associations of age at menarche (AAM) with health-related outcomes in East Asians? SUMMARY ANSWER AAM is associated osteoporosis, Type 2 diabetes (T2D), glaucoma, and uterine fibroids, as demonstrated through observational studies, polygenic risk scores, genetic correlations, Mendelian randomization (MR), additional findings indicating a causal effect BMI T2D on earlier AAM. WHAT IS KNOWN ALREADY Puberty timing linked to adult disease risk, but research...
Individuals with a mild traumatic brain injury (mTBI) often have executive control deficits; however, the underlying neural mechanisms of such deficits are yet to be clarified. Inhibitory and cognitive monitoring two fundamental aspects processes. This study investigated mTBI by using Stop-signal task. Eighteen adults 18 age-, sex-, education level-matched controls were recruited. Behavioral performance event-related potential correlates response inhibition error processing compared between...