A5100708210- Mathematical and Theoretical Epidemiology and Ecology Models
- Connective tissue disorders research
- Asthma and respiratory diseases
- Mitochondrial Function and Pathology
- Scoliosis diagnosis and treatment
- Neuroscience and Neuropharmacology Research
- Nonlinear Differential Equations Analysis
- Salivary Gland Disorders and Functions
- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic factors in colorectal cancer
- Mast cells and histamine
- Prostate Cancer Diagnosis and Treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Ear and Head Tumors
- Advanced Proteomics Techniques and Applications
- Infectious Diseases and Mycology
- Magnolia and Illicium research
- Autophagy in Disease and Therapy
- Congenital heart defects research
- Advanced Drug Delivery Systems
- Nuclear Receptors and Signaling
- Therapeutic Uses of Natural Elements
- Nonlinear Dynamics and Pattern Formation
- Ion Transport and Channel Regulation
Chang Gung University
2021-2025
Harbin Normal University
2010-2025
Taiwan Semiconductor Manufacturing Company (Taiwan)
2025
Kunming Medical University
2023-2024
China Medical University
2014-2024
China Medical University Hospital
2023-2024
Nanjing Drum Tower Hospital
2019-2023
Southeast University
2023
University of Massachusetts Chan Medical School
2023
China Medical University
2023
Abstract We conducted the first genome‐wide association study (GWAS) of prostate cancer (PCa) in Taiwan with 1844 cases and 80,709 controls. Thirteen independent single‐nucleotide polymorphisms (SNPs) reached significance ( p < 5 × 10 −8 ). Among these, three were distinct from previously identified loci: rs76072851 CORO2B gene (15q23), odds ratio (OR) = 1.54, 95% confidence interval (CI), 1.36–1.76, 5.30 −11 ; rs7837051, near two long noncoding RNA (lncRNA) genes, PRNCR1 PCAT2 (8q24.21),...
Abstract Polyoxometalates (POMs) are promising electrocatalysts and pseudo‐capacitive materials due to their reversible multi‐electron redox properties. In this study, Dawson‐type mono‐arsenic‐capped arsenomolybdate anchored into channels of {Cu(trz) 2 } 7 metal–organic network yielding a solution‐stable host‐guest structure, [{Cu I (trz) {As III As V Mo 4 VI 14 O 62 }] ·3H ( ), which exhibits higher conductivity specific capacity, excellent rate performance cycle stability than (biz) 9...
Aging may affect quality of life (QOL). This study aimed to evaluate the impact semi-immersive VR-based exercise on QOL young-old and middle-old adults. was a randomized controlled trial involving older adults aged 65–85 years. Methods: Two age groups were each randomly assigned experimental (EG) control (CG) groups. The EG underwent 75–90 min intervention twice week for 12 weeks, whereas CG continued with their usual daily activities. Each participant’s psychological assessed using World...
Psoriasis is a chronic inflammatory dermatological disease, and there lack of understanding the genetic factors involved in psoriasis Taiwan. To establish associations between variations psoriasis, genome‑wide association study was performed cohort 2,248 individuals with 67,440 without psoriasis. Using ingenuity pathway analysis software, biological networks were constructed. Human leukocyte antigen (HLA) diplotypes haplotypes analyzed using Attribute Bagging (HIBAG)‑R software chi‑square...
Summary Aim Differentiated embryonic chondrocyte gene 1 ( DEC 1) is involved in the neuronal differentiation and development. The aim of this study to investigate role 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine MPP + )‐induced PD model. Methods location tyrosine hydroxylase TH )‐positive neurons were detected by immunofluorescence. MPTP mouse subacute model was established evaluate change expression midbrain. Then, SH ‐ SY 5Y cells used ‐induced neurotoxicity. Results We showed that...
Background: The aim of this study was to determine the effect Facebook remote live-streaming-guided exercise on functional fitness community-dwelling older adults. Method: This used a non-randomized controlled design with single-blinding (outcome assessors). Older adults (mean age = 70.36 ± 4.51 years) were assigned either experimental group ( n 39) or control 34). participated in 75-min routine twice week for 8 weeks at home, whereas maintained their original lifestyle without any...
ABSTRACT Cells switch to anaerobic glycolysis when there is a lack of oxygen during brain ischemia. Extracellular pH thus drops and such acidosis causes neuronal cell death. The fate astrocytes, mechanical, functional partners neurons, in less studied. In this report, we investigated the signaling acidosis‐challenged rat cortical astrocytes whether these signals were related mitochondrial dysfunction Exposure acidic (6.8, 6.0) caused Ca 2+ release influx, p38 MAPK activation, Akt inhibition....
The incidence of diabetes-associated cognitive dysfunction (DACD) is increasing; however, few clinical intervention measures are available for the prevention and treatment this disease. Research has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, particularly SBC-115076, have a protective effect against various neurodegenerative diseases. However, their role in DACD remains unknown. In study, we aimed to explore impact PCSK9 inhibitors on DACD.
Acute ischemic stroke is one of the leading causes death in developed countries and most common cause disability adults worldwide. Despite advances understanding pathophysiology, therapeutic options remain limited. In this study, we explored interaction Shrm4 metabotropic gamma-aminobutyric acid (GABA) receptors (GABAB ) stroke. A transient middle cerebral artery occlusion (MCAO) model was induced by filament insertion Shrm4+/+ wild-type C57BL/6J mice, followed reperfusion for up to 7 days....
In Brief Study Design. A case–control study. Objective. This study aimed to investigate the potential role of PIEZO2 gene in development AIS. Summary Background Data. Mutations have been reported be associated with progressive scoliosis and impaired proprioception. Previous studies showed that patients AIS may However, there is lack knowledge concerning mechanism underlying proprioception etiology Methods. Proprioception tests were performed both age-matched healthy controls. Based on...
Study Design. A genetic association study. Objective. The aim of this study was to investigate whether rs1978060 TBX1 gene a susceptible locus adolescent idiopathic scoliosis (AIS) in the Chinese Han population and better define functional role development progression AIS. Summary Background Data. recent genome-wide reported novel gene, which associated with AIS Japanese population. However, there is paucity knowledge concerning Methods. SNP genotyped 1725 female patients 2600 healthy...
Study Design. A genetic association study. Objective. The aim of this study was to determine whether variants ABO, SOX6, and CDH13 are associated with the susceptibility AIS in Chinese Han population. Summary Background Data. recent large-scale genome-wide reported three novel loci , ABO SOX6 genes adolescent idiopathic scoliosis (AIS) Japanese However, these other populations remains obscure. Methods. SNPs rs4513093, rs687621, rs1455114 were genotyped 1208 female patients 2498 healthy...