A5100419239- Endometriosis Research and Treatment
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Natural product bioactivities and synthesis
- Estrogen and related hormone effects
- Neurological Disease Mechanisms and Treatments
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Psoriasis: Treatment and Pathogenesis
- Uterine Myomas and Treatments
- Liver Disease and Transplantation
- Pregnancy and preeclampsia studies
- Medical Research and Treatments
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Data Management and Algorithms
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- Pregnancy-related medical research
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Fujian Medical University
2024
Putian University
2024
Capital Medical University
2014-2024
Children's Hospital of Zhejiang University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Soochow University
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Renji Hospital
2024
Shanghai Jiao Tong University
2012-2024
Androgen and its receptor (AR) play a critical role in reproductive function under both physiological pathophysiological conditions. Female AR global knockout mice are subfertile due to neuroendocrine ovarian defects. offspring from prenatally androgenized heterozygous pregnant showed rescued estrous cyclicity fertility. Ar is expressed granulosa cells, theca interstitial oocytes the ovary. We created with theca-specific deletion of (ThARKO) by crossing Cyp17-iCre that express Cre...
Polycystic ovary syndrome is the major cause of infertility in reproductive aged women. associated with high circulating levels androgens and impaired metabolic function. The goal this study was to understand how androgen signaling via receptor (AR) affects We knocked out AR gene specifically pituitary gonadotropes (PitARKO) explore role on development function female mice. There no difference age puberty between control PitARKO littermates, which assessed by ages vaginal opening first...
Defect-free single atom array in optical tweezers is a promising platform for scalable quantum computing, simulation, and metrology. Extending single-species to mixed-species one promise offer new possibilities. In our recent proof of principle realization defect-free two-dimensional assembly $^{85}$Rb ($^{87}$Rb) arrays [C. Sheng et al.\href{https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.128.083202}{{\color{blue} Phys. Rev. Lett. 128, 083202(2022)}}], the filling fractions were...
The association between fetal gender and pregnancy outcomes has been thoroughly demonstrated in western populations. However, this not documented China. primary objective of the present study is to determine whether adverse labour with male fetuses applies Chinese population.This cross-sectional hospital-based retrospective survey collected data from thirty-nine hospitals 2011 mainland A total 109,722 women singleton who delivered after 28 weeks gestation were included.Of these pregnancies,...
Androgen excess in women is associated with metabolic dysfunction (e.g., obesity, hyperinsulinemia, insulin resistance, and increased risk of type 2 diabetes) reproductive polycystic ovaries, amenorrhea, dysregulated gonadotropin release, infertility). We sought to identify the effects androgen on glucose specific mechanisms action by which androgens are inducing pathology. developed a mouse model that displayed pathophysiological serum levels normal body mass/composition ensure phenotypes...
Jiawei Foshou San (JFS) is the new formula originated from classic formula, composed with ligustrazine, ferulic acid, and tetrahydropalmatine. Previously JFS inhibited growth of endometriosis (EMS) unclear mechanism, especially in metastasis, invasion, epithelial-mesenchymal transition. In this study, network pharmacology was performed to explore potential mechanism on EMS. Through compound-compound target compound target-EMS networks, key targets were analyzed for pathway enrichment....
Abstract Background There is a high prevalence of diabetes mellitus (DM) and dyslipidemia in women with polycystic ovary syndrome (PCOS). The purpose this study was to investigate the role different metabolic pathways development high-androgen female mice fed high-fat diet. Methods Female Sprague-Dawley rats were divided into 3 groups: control group(C), n = 10; andronate-treated group (Andronate), 10 (treated andronate, 1 mg/100 g body weight/day for 8 weeks); diet (Andronate+HFD), 10. rate...
Background Bone morphogenetic protein receptor I B (BMPR1B) is a transmembrane mediating TGF-β signal transduction. Recent studies indicate tumor suppressor role for BMPR1B in ovarian cancer. Polymorphism at 3′UTR within the miR-125b binding site alters its affinity toward miRNA, which may result insufficient post-transcriptional repression. Methods Single-nucleotide polymorphisms rs1970801, rs1434536, and rs11097457 near were genotyped by Taqman assay on 193 endometriosis patients 202...
Aberrant miRNA expression has been reported in endometriosis and gene polymorphisms have linked to cancer. Because certain ovarian cancers arise from endometriosis, we genotyped seven cancer-related single nucleotide (MiRSNPs) investigate their possible roles endometriosis. Genetic variants MIR196A2 (rs11614913) MIR100 (rs1834306) were found be associated with development related clinical phenotypes, such as infertility pain. Downstream analysis of the risk allele revealed upregulation rRNA...
Abstract Background Many efforts have been focused on the alternative glycemic marker glycated albumin (GlyA) and its application in pregnancy during which profound physiological changes take place. Our objective was to determine reference intervals (RIs) of GlyA healthy Chinese pregnant women assess predictive value serum adverse outcomes. Methods Totally 421 subjects including 137 first trimester, 152 second 132 third trimester were enrolled from March July 2019, for purpose establishing...
Background: Clinical research found that Hedysarum Multijugum Maxim. - Chuanxiong Rhizoma Compound (HCC) has definite curative effect on cerebral ischemic diseases, such as stroke and ischemia-reperfusion injury (CIR). However, its mechanism for treating ischemia is still not fully explained. Methods: The traditional Chinese medicine related database were utilized to obtain the components of HCC. Pharmmapper used predict HCC’s potential targets. CIR genes obtained from Genecards OMIM...
<b><i>Background:</i></b> The burden of Parkinson’s disease (PD) is still increasing, and physical activity a modifiable factor for health benefits. benefits in PD are not well established. Therefore, this study aimed to investigate the association between various types risk developing PD. <b><i>Methods:</i></b> Data from 432,497 participants UK Biobank, who were free at baseline, analyzed. Physical levels assessed by measuring duration walking...
Genetic alterations of mucin genes, such as MUC2 and MUC4, were previously identified to be associated with endometriosis related infertility. Additionally, gene expression profiling has confirmed MUC17 overexpressed in mucinous ovarian carcinoma; however, its risk for remains unclear. This study was focused on the potential impact genetic variations development clinical features. The subjects included 189 female Taiwanese patients pathology-proven 191 healthy women controls. Five...
Catalpol and puerarin are active ingredients isolated from Rehmannia glutinosa Libosch Radix Puerariae, respectively.They popular in research for their poly-pharmacological effects.This focused on effect of anti-stroke by lyophilized powder catalpol (C-P) potential mechanisms.At the beginning research, C-P was identified analyzed HPLC.Neurological function evaluated Longa score, neurological complex score beam balance after permanent middle cerebral artery occlusion (PMCAO) mice.Infarct...
Objective: To explore the association between maternal age and perinatal outcomes. Methods: Totally, 3 151 women with advanced 6 098 younger than 35 years old who delivered in Beijing Obstetrics Gynecology Hospital 2016 were recruited. Their clinic characteristics outcomes collected to divide into groups based on delivery age, Group 1 (aged 35-39 years, 2 683 cases), ≥40 366 cases) control group (aged<35 cases). The adverse analyzed, including hypertensive disorder complicating pregnancy,...