A5051184194- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Thermal Regulation in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurosurgical Procedures and Complications
- Neurological Disease Mechanisms and Treatments
- Cerebral Venous Sinus Thrombosis
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Circular RNAs in diseases
- Cardiac Arrest and Resuscitation
- Optical Imaging and Spectroscopy Techniques
- Atrial Fibrillation Management and Outcomes
- MicroRNA in disease regulation
- COVID-19 and healthcare impacts
- Cancer-related molecular mechanisms research
- Intracranial Aneurysms: Treatment and Complications
- Immune Cell Function and Interaction
- Neonatal and fetal brain pathology
- Cardiac Ischemia and Reperfusion
First Affiliated Hospital of Wannan Medical College
2025
Kunming University of Science and Technology
2024-2025
First People's Hospital of Yunnan Province
2024-2025
Capital Medical University
2015-2024
Henan Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Zhejiang University
2024
Sir Run Run Shaw Hospital
2024
Guiyang Medical University
2024
Beijing Friendship Hospital
2022
The effects and risks of endovascular thrombectomy 6 to 24 hours after stroke onset due basilar-artery occlusion have not been extensively studied.
Background and Purpose— Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, whether tirofiban is safe effective in these treated with endovascular thrombectomy (ET) unknown. This study evaluated the safety efficacy AIS ET. Methods— observational based on a single-center prospective registry study. Patients undergoing ET second-generation stent retrievers from January 2013 to February 2017 were alone or plus low...
This is a prospective non-randomized cohort study of 113 consecutive patients to investigate the safety and efficacy short-duration intraarterial selective cooling infusion (IA-SCI) targeted into an ischemic territory combined with mechanical thrombectomy (MT) in large vessel occlusion-induced acute stroke (AIS); 45/113 underwent IA-SCI 350 ml 0.9% saline at 4℃ for 15 min discretion interventionalist. Key parameters such as vital signs key laboratory values, symptomatic any intracranial...
Rationale There are no randomized trials examining the best treatment for acute basilar artery occlusion in 6–24-hour time window. Aims To assess safety and efficacy of thrombectomy stroke due to patients within 6–24 h from symptom onset or last seen well. Sample size For an estimated difference 20% proportions primary outcome between two groups, 318 will be included 5% significance 90% power with a planned interim analysis after two-thirds sample (212 patients) have achieved 90 days...
<h3>Objective</h3> To investigate whether elevated plasma trimethylamine N-oxide (TMAO) levels are associated with initial stroke severity and infarct volume. <h3>Methods</h3> This cross-sectional study included 377 patients acute ischemic 50 healthy controls. Plasma TMAO were assessed at admission. Stroke size clinical measured diffusion-weighted imaging the NIH Scale (NIHSS). Mild was defined as an NIHSS score <6. <h3>Results</h3> higher in than controls (median 5.1 vs 3.0 μmol/L;...
To investigate the safety and efficacy of normobaric hyperoxia (NBO) combined with endovascular treatment (EVT) in patients acute ischemic stroke (AIS).In this single-center, proof-of-concept, assessor-blinded, randomized, controlled pilot study, AIS anterior circulation large vessel occlusion who had an indication for EVT were randomly assigned to group or NBO + group. The was given 100% oxygen through a face mask initiated before vascular recanalization (10L/min 4 hours), while room air....
Over decades, nearly all attempts to translate the benefits of therapeutic hypothermia in stroke models lower-order species patients have failed. Potentially overlooked reasons may be biological gaps between different and mismatched initiation translational studies. Here, we introduce a novel strategy selective non-human primate ischemia-reperfusion model, which autologous blood was cooled ex vivo cool transfusion administered at middle cerebral artery just after onset reperfusion. Cold...
Few studies have suggested a relationship between inflammation and cerebral venous thrombosis (CVT). This retrospective study aimed to explore the changes in different CVT stages correlation severity outcome of CVT.In total, 95 suitable patients with 41 controls were compared. Patients divided into three groups. The inflammatory factors studied included hypersensitive C-reactive protein (Hs-CRP), interleukin-6 (IL-6), neutrophil-to-lymphocyte ratio (NLR) peripheral blood immunoglobulin A...
To investigate the feasibility and safety of remote ischemic postconditioning (RIPC) in acute stroke patients after intravenous recombinant tissue plasminogen activator (rt-PA) thrombolysis (IVT).We performed a pilot randomized trial involving with IVT. The were 1:1 to receive RIPC or standard medical therapy. In group, participants underwent instant within 2 h IVT, followed by repeated therapy for 7 days. end point was completion time from first finishing IVT group. included neurovascular...
Abstract Objective This study evaluates reocclusion prognostic outcomes and explores risk factors after mechanical thrombectomy (MT) in Chinese stroke patients. Methods Altogether, 614 patients with AIS successful recanalization MT were recruited this divided into the non‐reocclusion group depending on 24‐h imaging results MT. Differences between two groups compared including 7‐day National Institutes of Health Stroke Scale (NIHSS) scores, 90‐day modified Rankin scale(mRS) good prognosis...
Nearly all stroke neuroprotection modalities, including selective intra-arterial cooling (SI-AC), have failed to be translated from bench bed side. Potentially overlooked reasons may biological gaps, inadequate attention reperfusion states and mismatched neurological benefits. To advance translation, we describe a novel thrombus-based model in adult rhesus macaques. Intra-arterial thrombolysis with tissue plasminogen activator leads three clinically relevant outcomes – complete, partial, no...
Abstract Drug resistance remains a major hurdle for the therapeutic efficacy of lenvatinib in hepatocellular carcinoma (HCC). However, underlying mechanisms remain largely undetermined. Unbiased proteomic screening is performed to identify potential regulators HCC. Patient‐derived organoids, patient‐derived xenograft mouse models, and DEN/CCl 4 induced HCC models are constructed evaluate effects HECTD2 both vitro vivo. found be highly expressed lenvatinib‐resistant cell lines, patient...
To investigate the role of mitochondrial ribosomal proteins (MRPs) in pathogenesis and progression septic myocardial injury. Additionally, we aim to propose new technical strategies experimental foundations for prevention treatment Animal cell models injury were established. Aberrantly expressed MRPs screened using transcriptome sequencing, their expression was verified by RT-qPCR Western blot. Subsequently, overexpressed knockdown constructed. The effects on CO I, PGC-1α, ATP content, ROS...
Serum albumin levels has been shown to predict outcome in ischemic stroke patients. We aimed investigate the relationship between serum and hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) patients with acute stroke. 428 receiving rt-PA therapy were included from 2013 2016 categorized into two groups: low level (<35 mmol/L) normal (35-55 group. Demographic, clinical laboratory information, HT functional outcomes analyzed. Hemorrhagic was comfirmed by CT scan or MRI within...
To evaluate the incidence of post-interventional contrast staining (PICS) in acute ischemic stroke (AIS) Chinese patients who were treated with endovascular thrombectomy (ET) and investigate potential association PICS functional outcome intracerebral hemorrhage (ICH). This observational study was based on a single-center prospective registry study. AIS underwent ET from January 2013 to February 2017 recruited into this All had dual-energy CT (DECT) scan head at 12 24 hours post-ET. The...
Acute ischemic stroke due to basilar artery occlusion (BAO) carries a very poor prognosis. Functional outcomes in BAO patients undergoing endovascular therapy (EVT) may differ according the specific pathological mechanisms. We aimed explore impact of underlying mechanisms on prognosis at 90-days and long-term follow-up treated with EVT. analyzed consecutive EVT from December 2012 2018 single center (Xuanwu Hospital). Patients were classified into either an intracranial atherosclerotic...
Abstract Aims To evaluate pulsatility index (PI) in patients with acute ischemic stroke (AIS) who underwent endovascular thrombectomy (EVT). Methods Patients were retrospectively recruited if their secondary to middle cerebral artery (MCA) occlusion and achieved full recanalization after EVT. Transcranial Doppler was performed within 24‐hour post‐EVT. The primary outcome correlation between the MCA‐PI on affected side 3‐month functional outcome, modified Rankin scale (mRS) ≥5 indicated...
Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection, but current catheters do not support thermally-insulated transfer of cold infusate, which results in an increased exit temperature, causes hemodilution, and limits its cooling efficiency. Herein, air-sprayed fibroin/silica-based coatings combined with chemical vapor deposited parylene-C capping film was prepared on catheter. This coating features dual-sized-hollow-microparticle incorporated...
Salvinorin A (SA) exerts neuroprotection and improves neurological outcomes in ischemic stroke models rodents. In this study, we investigated whether intranasal SA administration could improve a monkey model. The model was induced adult male rhesus monkeys by occluding the middle cerebral artery M2 segment with an autologous blood clot. Eight were randomly administered or 10% dimethyl sulfoxide as control 20 min after ischemia. Magnetic resonance imaging used to confirm ischemia extent of...