Liping Wei
A5057206919- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Muscle metabolism and nutrition
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Allergic Rhinitis and Sensitization
- Traumatic Brain Injury and Neurovascular Disturbances
- Angiogenesis and VEGF in Cancer
- Cell death mechanisms and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- S100 Proteins and Annexins
- IL-33, ST2, and ILC Pathways
- Coronary Interventions and Diagnostics
- Biomarkers in Disease Mechanisms
- Diet and metabolism studies
- Autophagy in Disease and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mitochondrial Function and Pathology
- Neurological Complications and Syndromes
Air Force Medical University
2009-2025
Nankai University
2019-2024
Tianjin People's Hospital
2016-2024
Guangxi University of Chinese Medicine
2019-2024
The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
2024
Union Hospital
2024
Jilin University
2024
Luoyang Central Hospital Affiliated to Zhengzhou University
2013-2023
Guangxi University
2023
Institute of Cardiology
2022
The effects and risks of endovascular thrombectomy 6 to 24 hours after stroke onset due basilar-artery occlusion have not been extensively studied.
Background and Purpose: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice developing countries like China needs to be confirmed. aim the study was determine whether EVT acute ischemic stroke randomized trials could generalized Chinese population. Methods: We conducted a prospective registry at 111 centers China. Patients with caused by imaging-confirmed intracranial receiving were included. primary outcome functional independence 90 days defined as...
Abstract Background Diabetes and hyperlipidaemia are both risk factors for coronary artery disease, associated with a high triglyceride-glucose index (TyG index). The TyG has been presented as marker of insulin resistance (IR). Its utility in predicting detecting cardiovascular disease reported. However, few studies have found it to be helpful atherosclerosis patients symptomatic (CAD). purpose this study was demonstrate that the can serve valuable carotid CAD patients, regardless diabetes...
The endoplasmic reticulum (ER) plays a vital function in maintaining cellular homeostasis. Endoplasmic stress (ERS) can trigger various modes of cell death by activating the unfolded protein response (UPR) signaling pathway. Cell crucial role occurrence and development diseases such as cancer, liver diseases, neurological cardiovascular diseases. Several including hypertension, atherosclerosis, heart failure are associated with ER stress. stress-mediated is interest disease. Moreover, an...
Diabetes Mellitus (DM) is widely acknowledged to increase the risk of cardiovascular death, which warrants use aggressive primary prevention strategies. The aim present study was investigate pretreatment effects tanshinone IIA (TSN), a traditional Chinese medicine, on myocardial infarct size, apoptosis, inflammation and cardiac functional recovery in diabetic rats subjected ischaemia/reperfusion (I/R).Streptozocin (STZ) induced (n = 80) were randomized receive TSN, TSN plus wortmannin [a...
BackgroundLimited data exist on VTE risk and prophylaxis in Chinese inpatients. The Identification of Hospitalized Patients' Risk Profile for Venous Thromboembolism-2 (DissolVE-2), a nationwide, multicenter, cross-sectional study, was therefore designed to investigate prevalence risks evaluate implementation compliant with the latest guidelines (American College Chest Physicians [CHEST], 9th edition).MethodsAdults admitted (≥ 72 h) 60 urban, tertiary hospitals due acute medical conditions or...
Characterization of the rupture risk factors for small intracranial aneurysms (SIAs, ≤5 mm) is clinically valuable. The present study aims to identify image-based morphological parameters and anatomical locations associated with status SIAs. Two hundred sixty-three patients single SIAs (128 ruptured, 135 unruptured) were included, six parameters, including size, aspect ratio (AR), size (SR), height-width (H/W), flow angle (FA) aneurysm width-parent artery diameter ratio, evaluated using...
Background and Purpose: A recent randomized controlled trial DIRECT-MT (Direct Intra-Arterial Thrombectomy to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals) compared the safety efficacy of mechanical thrombectomy (MT) versus combined intravenous thrombolysis (IVT) MT for acute large vessel occlusion. The current study utilized a prospective, nationwide registry validate results real-world practice setting. Methods: Subjects were selected...
Background Diabetic cardiomyopathy (DCM) lacks specific and sensitive biomarkers, its diagnosis remains a challenge. Therefore, there is an urgent need to develop useful biomarkers help diagnose evaluate the prognosis of DCM. This study aims find diagnostic markers for diabetic cardiomyopathy. Methods Two datasets (GSE106180 GSE161827) from GEO database were integrated identify differentially expressed genes (DEGs) between control type 2 We assessed infiltration immune cells used weighted...
Abstract Oncostatin M ( OSM ) exhibits many unique biological activities by activating Oβ receptor. However, its role in myocardial I/R injury diabetic mice remains unknown. The involvement of was assessed which underwent treatment or genetic deficiency receptor Oβ. Its mechanism on cardiomyocyte apoptosis, mitochondrial biogenesis and insulin sensitivity were further studied. alleviated cardiac inhibiting apoptosis through inhibition inositol pyrophosphate 7 IP 7) production, thus PI...
During myocardial infarction, quickly opening the occluded coronary artery is a major method to save ischemic myocardium. However, it also induces reperfusion injury, resulting in poor prognosis. Alleviating injury improves prognosis of patients. Dihydromyricetin (DHM), component Ampelopsis grossedentata, has numerous biological functions. This study aims clarify effects DHM under ischemia/reperfusion (I/R) condition. We elucidated role Sirt3 cardiomyocyte response based on hearts and...
Sex disparities in acute large vessel occlusion (LVO) following endovascular treatment (EVT) have been recently reported. However, there is uncertainty about the effect of sex differences on functional outcomes after EVT, particularly an Asian population. The present study aimed to compare clinical and safety between men women with anterior circulation LVO treated EVT.
Branched chain amino acids (BCAA) are particularly effective anabolic agents. Recent in vitro studies suggest that acids, leucine, activate a signaling pathway enhances messenger ribonucleic acid translation and protein synthesis. The physiological relevance of these findings to normal human physiology is uncertain. We examined the effects BCAA on phosphorylation eukaryotic initiation factor 4E-binding 1 (eIF4E-BP1) ribosomal S6 kinase (p70S6K) skeletal muscle seven healthy volunteers....
Studies in vitro as well vivo rodents have suggested that amino acids (AA) not only serve substrates for protein synthesis, but also nutrient signals to enhance mRNA translation and synthesis skeletal muscle. However, the physiological relevance of these findings normal humans is uncertain. To examine whether AA regulate synthetic apparatus human muscle, we infused an mixture (10% Travesol) systemically into 10 young healthy male volunteers 6 h. Forearm muscle degradation (phenylalanine...
In patients undergoing mechanical thrombectomy (MT), adjunctive antithrombotic might improve angiographic reperfusion, reduce the risk of distal emboli and reocclusion but possibly expose to a higher intracranial hemorrhage risk. This study evaluated safety efficacy combined MT plus eptifibatide for acute ischemic stroke. was propensity-matched analysis data from 2 prospective trials in Chinese populations: ANGEL-ACT trial (Endovascular Treatment Key Technique Emergency Workflow Improvement...
Introduction Electrical impedance tomography (EIT) enables non-invasive, continuous, bedside evaluation of ventilation/perfusion (V/Q) match. To avoid the presence invasive monitoring for cardiac output in relative V/Q ratio calculation, we proposed a novel calibration method based on arterial blood pressure to optimize EIT match assessments. Methods We involved 12 mechanically ventilated piglets three experimental phases: baseline, pulmonary embolism, and atelectasis. After thorough...
Metabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition long-chain 3-ketoacyl CoA thiolase heart. So, commonly used cardiovascular therapy as myocardial metabolic drug. This study was conducted to assess effects mechanisms on ketone body metabolism failure rats.A rat model established by continuous subcutaneous injection isoproterenol 10 mg/kg/d. We examined weight, weight index, tested B-type...
Oncostatin M (OSM) has been reported to stimulate angiogenesis by upregulating VEGF and bFGF, implying that it could be a therapeutic strategy in treating ischemic diseases. The present study was aimed at investigating whether OSM improve cardiac function via prompting following myocardial infarction (MI). Wild type (WT) O β knock-out (O −/− ) mice were, respectively, randomized into sham group, MI + vehicle group. WT displayed significantly impaired after MI. treatment attenuated...
Refeeding reverses the muscle protein loss seen with fasting. The physiological regulators and cellular control sites responsible for this reversal are incompletely defined. Phosphorylation of phosphorylated heat-acid stabled (PHAS-I) frees eukaryotic initiation factor 4E (eIF4E) stimulates synthesis by accelerating translation initiation. p70 S6-kinase (p70 S6k ) is thought to be involved in regulation some ribosomsal proteins other selected polypyrimidine clusters near transcription start...
Diabetes is associated with an increased risk of cardiac microvascular disease. The mechanisms by which this damage occurs are unknown. However, research suggests that signaling through the sphingosine-1-phosphates receptor 1 and 3 (S1P1/3) FTY720, a sphiongolipid drug structually similar to SIP, may play role in treatment on dysfunction diabetes. We hypothesized FTY720 might exert cardioprotective effects S1P1 S1P3 viaprotein kinase C-beta (PKCβ II) pathway.Transthoracic echocardiography...
Background and purpose 5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke (AIS) due to large vessel occlusion anterior circulation. This study aims evaluate safety efficacy Solitaire thrombectomy in patients with moderate-to-severe Chinese population, which has a high prevalence intracranial atherosclerosis. Methods analysis multicentre prospective control will involve 17 centres China, plans recruit 150 intervention group, medical meet enrolment...