A5100695807- Calcium Carbonate Crystallization and Inhibition
- Bone Tissue Engineering Materials
- Marine Bivalve and Aquaculture Studies
- Paleontology and Stratigraphy of Fossils
- Marine Biology and Environmental Chemistry
- Autophagy in Disease and Therapy
- Phytoestrogen effects and research
- Cephalopods and Marine Biology
- Angiogenesis and VEGF in Cancer
- Minerals Flotation and Separation Techniques
- Cardiac Ischemia and Reperfusion
- Signaling Pathways in Disease
- Alkaline Phosphatase Research Studies
- Bone and Dental Protein Studies
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- Cardiovascular Function and Risk Factors
- Mesenchymal stem cell research
- Biomarkers in Disease Mechanisms
- Vitamin K Research Studies
- Hippo pathway signaling and YAP/TAZ
- Growth Hormone and Insulin-like Growth Factors
- Apelin-related biomedical research
- Mitochondrial Function and Pathology
- RNA modifications and cancer
Tsinghua University
2016-2025
Beijing Tongren Hospital
2025
Capital Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Shanghai Ocean University
2023
Jiaxing University
2020-2022
Air Force Medical University
2007-2016
Xijing Hospital
2004-2016
Qinghai University
2014-2016
Fudan University
2013
Impaired cardiac microvascular function contributes to cardiovascular complications in diabetes. Glucagon-like peptide-1 (GLP-1) exhibits potential cardioprotective properties addition its glucose-lowering effect. This study was designed evaluate the impact of GLP-1 on injury diabetes and underlying mechanism involved. Experimental induced using streptozotocin rats. Cohorts diabetic rats received a 12-week treatment vildagliptin (dipeptidyl peptidase-4 inhibitor) or exenatide (GLP-1 analog)....
The shells of pearl oysters, Pinctada fucata, are composed calcite and aragonite possess remarkable mechanical properties. These formed under the regulation macromolecules, especially shell matrix proteins (SMPs). Identification diverse SMPs will lay a foundation for understanding biomineralization process. Here, we identified 72 unique using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis extracted from P. fucata combined with draft genome. Of SMPs, 17 related to both...
Myocardial infarction (MI), which is characterized by chamber dilation and LV dysfunction, associated with substantially higher mortality. We investigated the effects underlying mechanisms of Luteolin on post-infarction cardiac dysfunction. was constructed left anterior descending coronary artery ligation. In vitro, cultured neonatal cardiomyocytes subjected to simulated MI were used probe mechanism. significantly improved function, decreased enzyme inflammatory cytokines release after MI....
The growth of molluscan shell crystals is generally thought to be initiated from the extrapallial fluid by matrix proteins, however, cellular mechanisms formation pathway remain unknown. Here, we first report amorphous calcium carbonate (ACC) precipitation biomineralization in primary mantle cell cultures Pinctada fucata. Through real-time PCR and western blot analyses, demonstrate that cells retain ability synthesize secrete ACCBP, Pif80 nacrein vitro. In addition, also maintained high...
Aims: Clinical application of cellular therapy for cardiac regeneration is significantly hampered by the low retention engrafted cells, mainly attributable to poor microenvironment dominated inflammation and oxidative stress in host's infarcted myocardium. This study aims at investigating whether liver X receptor (LXR) agonist T0901317 will improve survival adipose-derived mesenchymal stem cells (AD-MSCs) after transplantation into hearts. Results: Noninvasive vivo bioluminescence imaging...
The molluscan Pinctada fucata is an important pearl-culturing organism to study biomineralization mechanisms. Several biomineralization-related genes play roles regulating shell formation, but most previous work has focused only on their functions in adult oysters. Few studies have investigated during larval development, when the initially constructed and formed until juvenile stage dissoconch shells. Here, we report, for first time, a global gene analysis development of P. based microarray...
Cardiovascular complications account for a substantial proportion of morbidity and mortality in diabetic patients. Abnormalities cardiac microvascular endothelial cells (CMECs) lead to impaired vessel integrity subsequent dysfunction, underlining the importance coronary dysfunction. In this study, experimental diabetes models were constructed using Mst1 transgenic, knockout sirt1 mice. Diabetic transgenic mice exhibited microvessel decreased function. overexpression deceased CMECs autophagy...
In bivalves, the mantle tissue secretes organic matrix and inorganic ions into extrapallial space (EPS) to form shells. addition, more evidences indicate participation of hemocytes in shell mineralization, but no direct evidence has been reported that verifies presence EPS, their exact roles biomineralization remain uncertain. Here, we identified from EPS Pinctada fucata. Numerous components involved cellular humoral immunity were by proteome analysis, together with several proteins calcium...
Matrix proteins play important roles in shell formation. Our group firstly isolated three cDNAs encoding lysine-rich matrix protein from Pinctada fucata 2006. However, the functions of KRMPs are not fully understood. In addition, contain two functional domains, basic domain and Gly/Tyr respectively. Based on modular organization, their domains were poorly characterized. Furthermore, then reported other species, P. maxima margaritifera, which indicated that might be very for this study,...