A5068269611- Vaccine Coverage and Hesitancy
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Influenza Virus Research Studies
- Diet, Metabolism, and Disease
- Venous Thromboembolism Diagnosis and Management
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Biochemical effects in animals
- Antenna Design and Analysis
- Endoplasmic Reticulum Stress and Disease
- Advanced Antenna and Metasurface Technologies
- Hepatitis B Virus Studies
- Folate and B Vitamins Research
- Birth, Development, and Health
- Antioxidant Activity and Oxidative Stress
- Vagus Nerve Stimulation Research
- Gout, Hyperuricemia, Uric Acid
- Acupuncture Treatment Research Studies
- Immune responses and vaccinations
- Hepatitis Viruses Studies and Epidemiology
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
Zhejiang Center for Disease Control and Prevention
2014-2025
Qingdao University
2016-2025
First Affiliated Hospital Zhejiang University
2007-2025
Inner Mongolia Maternal and Child Health
2025
Hefei University of Technology
2023-2024
Jiangsu Province Hospital
2024
Nanjing Medical University
2024
East China Normal University
2023-2024
South China Normal University
2024
Xiangya Hospital Central South University
2017-2024
In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy.We conducted a trial at 41 academic tertiary care centers in China to evaluate thrombectomy with or without patients stroke. Patients stroke from large-vessel occlusion anterior circulation were randomly assigned 1:1 ratio undergo alone (thrombectomy-alone group) preceded by alteplase, dose 0.9 mg per kilogram body weight, administered within...
The effects and risks of endovascular thrombectomy 6 to 24 hours after stroke onset due basilar-artery occlusion have not been extensively studied.
Retrograde intrarenal surgery (RIRS) is the main treatments for upper urinary tract stones. The Ureteral Access Sheath (UAS) serves as a supplementary tool, facilitating direct kidney access during RIRS. High quality of evidence comparing tip bendable suction ureteral sheath (S-UAS) with traditional UAS in RIRS treatment renal and stones lacking. purpose study to compare efficacy safety S-UAS or ≤30 mm.
Abstract Background Neuroinflammation plays an important role in cerebral ischemia/reperfusion (I/R) injury. The P2X7 receptor (P2X7R) has been reported to be involved the inflammatory response of many central nervous system diseases. However, P2X7Rs transient global I/R injury remains unclear. purpose this study is determine effects inhibiting P2X7R a rat model injury, and then explore association between neuroinflammation after Methods Immediately infusion with antagonists Brilliant blue G...
Sodium butyrate, a short-chain fatty acid, is predominantly produced by gut microbiota fermentation of dietary fiber and serves as an important neuromodulator in the central nervous system. Recent experimental evidence has suggested that sodium butyrate may be endogenous ligand for two orphan G protein-coupled receptors, GPR41 GP43, which regulate apoptosis inflammation ischemia-related pathologies, including stroke. In present study, we evaluated potential efficacy mechanism action acids...
This study was aimed to explore the effects of fucoidan on iron overload and ferroptosis-induced liver injury, underlying mechanisms in rats exposed alcohol. Sprague-Dawley were used establish alcoholic injury model by intragastric administration with alcohol for 16 weeks. The results showed that treatment reversed alcohol-induced increases reactive oxygen species malondialdehyde levels, increased glutathione peroxidase thus protecting against damage. Long-term feeding resulted abnormal...
Background and Purpose: A recent randomized controlled trial DIRECT-MT (Direct Intra-Arterial Thrombectomy to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals) compared the safety efficacy of mechanical thrombectomy (MT) versus combined intravenous thrombolysis (IVT) MT for acute large vessel occlusion. The current study utilized a prospective, nationwide registry validate results real-world practice setting. Methods: Subjects were selected...
Emerging lines of research evidence point to a vital role gut-kidney axis in the development hyperuricemia (HUA), which has been identified as an increasing burden worldwide due high prevalence. The involved crosstalk links metabolic and immune-related pathways is mainly responsible for maintaining axial homeostasis uric acid (UA) metabolism. Nowadays, urate-lowering drugs only aim treat acute gouty arthritis result their controversial clinical application HUA. In this study, we established...
Sex disparities in acute large vessel occlusion (LVO) following endovascular treatment (EVT) have been recently reported. However, there is uncertainty about the effect of sex differences on functional outcomes after EVT, particularly an Asian population. The present study aimed to compare clinical and safety between men women with anterior circulation LVO treated EVT.
We tested the effect of vagus nerve stimulation in endotoxin-induced intestinal tight junction injury mice challenged with lipopolysaccharide (LPS) and examined role α7 nicotinic acetylcholine receptors (α7nAchR) this process. Endotoxemia was induced by intraperitoneal injection LPS (10 mg/kg) male Balb/c mice. Samples were collected 12 h after treatment. associated barrier dysfunction, as evidenced increased amount fluorescein isothiocyanate–dextran circulation. Western blot...
Fucoidan prevents the occurrence of ethanol-induced high apoptosis and mitophagy by scavenging ROS, maintains mitochondrial function balance.
Accumulating evidence points to a critical role of the brain gut axis as an important paradigm for many central nervous system diseases. Recent studies suggest that propolis has obvious neuroprotective properties and functionality in regulating intestinal bacteria flora, hinting at potential key effect both terminals this regulation. However, currently no clear confirms effects on alcohol-induced depression. Here, we establish alcoholic depression model with C57BL/6J mice demonstrate...
The gut–liver axis (GLA) plays an important role in the development of alcohol-induced liver injury. Alcohol consumption is typically associated with folic acid deficiency. However, no clear evidence has confirmed effect supplementation on injury via GLA homeostasis. In this study, male C57BL/6J mice were given 56% (v/v) ethanol and 5.0 mg/kg daily by gavage for 10 weeks to investigate potential protective mechanisms Histopathological biochemical analyses showed that improved lipid...
Limited data exist regarding the coverage of 13-valent pneumococcal conjugate vaccine (PCV13) in China. A lack official statistics, coupled with an insufficient body published literature, hinders accurate depiction current situation.This study investigated utilization PCV13 and estimated its nine provinces across eastern, central, western China between 2019 2021. Despite annual increase usage during this period, overall remained suboptimal.Consideration should be given to incorporating...
Fucoidan is a native sulfated polysaccharide mainly isolated from brown seaweed, with diverse pharmacological activities, such as anti-inflammatory and antifibrosis. Hyperuricemia (HUA) common metabolic disease worldwide causes hyperuricemic nephropathy, including chronic kidney end-stage renal fibrosis. The present study investigated the protective function of fucoidan in fibrosis its mechanism. fibrotic model was established administration potassium oxonate for 10 weeks. protein levels...
Ample evidence indicates that ethanol-induced oxidative stress and mitochondrial dysfunction are central to the pathogenesis of alcoholic liver disease (ALD). As an adaptive quality control mechanism, mitophagy removes dysfunctional mitochondria avert hepatic lesions in ALD. Folic acid exhibits potential radical scavenging properties has been proven ameliorate disorder stress-related diseases. In this study, we aimed uncover regulatory effects folic a 10w alcohol C57BL/6J mice feeding model...
The dysfunction of intestinal microbiota and bile acid metabolism is related to the pathogenesis atherosclerosis. This study we explored mechanism Bifidobacterium animalis subsp. lactis F1–7 (Bif. F1–7), improving atherosclerosis by regulating in ApoE–/– mice. Bif. effectively reduced aortic plaque accumulation improved serum liver lipid levels atherosclerotic untargeted metabolomics revealed that glycine-conjugated acids differential metabolite lithocholic (LCA) significantly....
Parkinson's disease (PD) is marked by the degeneration of dopaminergic neurons substantia nigra (SN), with neuroinflammation and mitochondrial dysfunction being key contributors. The neuroprotective potential folic acid (FA) in system PD was assessed a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model. MPTP (20 mg/kg body weight) administered to C57BL/6J mice simulate symptoms followed FA treatment (5 weight). Behavioral tests, pole, rotarod, open-field evaluated motor...
Combination targeted therapy is commonly used to treat acute myeloid leukemia (AML) patients, particularly in refractory/relapse (RR) population. However, concerns have been raised regarding the safety and patient tolerance of combination chemotherapy. It critical choose appropriate treatment for precision therapy. We performed genome-wide RNA profiling using RNA-Seq compare RR group complete remission (CR) (a total 42 adult AML patients). The Hedgehog (Hh) PI3K/AKT pathways were upregulated...
Background: Reasons for acceptance of seasonal influenza vaccine (SIV) vaccination among pregnant women in China are poorly understood. We assessed the intention to accept SIV Zhejiang province, by using a self-administrated structured questionnaire developed on basis health belief model (HBM). Methods: From 1 January 31 March 2014, with ≥12 gestational weeks who attended antenatal clinics (ANCs) at public hospitals 6 out 90 districts were surveyed self-administered that covered knowledge,...
About 15% of heterosexual couples in the USA suffer from infertility issues; male accounts for ∼50% all cases and roughly 50% is idiopathic. Increased levels plasma cholesterol affect spermatogenesis fertility negatively, but by unclear mechanisms. Clearly, occurs immune-privileged seminiferous tubules that are protected blood-testis barrier (BTB), BTB disruption results sperm damage infertility. Accordingly, using rabbits fed a 2% cholesterol-enriched diet 2, 4, 6 wk to raise cholesterol,...