A5086247489- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- EEG and Brain-Computer Interfaces
- Diabetes Treatment and Management
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Disease Prevention
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- Peripheral Artery Disease Management
Capital Medical University
2016-2025
National Clinical Research Center for Digestive Diseases
2016-2025
Beijing Tian Tan Hospital
2016-2025
Capital University
2022-2025
Chinese Academy of Sciences
2023-2025
Shanghai Institute of Materia Medica
2025
Guiyang Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Union Hospital
2024
University of Nottingham
2022-2024
Stroke is common during the first few weeks after a transient ischemic attack (TIA) or minor stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than alone.In randomized, double-blind, placebo-controlled trial conducted at 114 centers in China, we randomly assigned 5170 patients within 24 hours onset of high-risk TIA to combination (clopidogrel an initial dose 300 mg, followed by 75 mg per day for 90 days, plus 21 days) placebo...
China faces the greatest challenge from stroke in world. The death rate for cerebrovascular diseases was 149.49 per 100 000, accounting 1.57 million deaths 2018. It ranked third among leading causes of behind malignant tumours and heart disease. age-standardised prevalence incidence 2013 were 1114.8 000 population 246.8 person-years, respectively. According to Global Burden Disease Study 2017, years life lost (YLLs) increased by 14.6%; YLLs due rose highest all 1990 2017. absolute numbers...
China faces the greatest challenge from stroke in world. According to results Global Burden of Disease Study 2019, there were 3.94 million new cases, 28.76 prevalent cases and 2.19 deaths due 2019. Furthermore, is also leading cause disability-adjusted life-year (DALY) China, number DALYs reached 45.9 Several recent large-scale epidemiological surveys have updated data on pre-existing conditions contributed stroke. The age-adjusted prevalence overweight among Chinese adults aged 18–69 years...
Comparisons between ticagrelor and clopidogrel for the secondary prevention of stroke in CYP2C19 loss-of-function carriers have not been extensively performed.
Stroke is the leading cause of mortality and disability in China. Precise aetiological classification, imaging biological markers may predict prognosis stroke. The Third China National Registry (CNSR-III), a nationwide registry ischaemic stroke or transient attack (TIA) based on aetiology, biology markers, will be considered to clarify pathogenesis prognostic factors stroke.Between August 2015 March 2018, CNSR-III recruited consecutive patients with TIA from 201 hospitals that cover 22...
Background— The Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial showed that the combined treatment of clopidogrel and aspirin decreases 90-day risk stroke without increasing hemorrhage comparison alone, but provided insufficient data to establish whether benefit persisted over a longer period time beyond termination. We report 1-year follow-up outcomes this trial. Methods Results— was randomized, double-blind, placebo-controlled conducted at...
Dual antiplatelet therapy with clopidogrel and aspirin is effective for secondary prevention after minor ischemic stroke or transient attack (TIA). Uncertainties remained about the optimal duration of dual TIA.
Background and Purpose: Edaravone dexborneol, comprised of 2 active ingredients, edaravone (+)-borneol, has been developed as a novel neuroprotective agent with synergistic effects antioxidant anti-inflammatory in animal models. The present clinical trial aimed at testing the dexborneol versus on 90-day functional outcome patients acute ischemic stroke (AIS). Methods: A multicenter, randomized, double-blind, comparative, phase III was conducted 48 hospitals China between May 2015 December...
Abstract Background Triglyceride-glucose (TyG) index was recently suggested to be a reliable surrogate marker of insulin resistance. We aim investigate the associations between baseline and long-term TyG with subsequent stroke its subtypes in community-based cohort. Methods A total 97,653 participants free history Kailuan Study were included. calculated as ln (fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2). Baseline measured during 2006–2007. Updated cumulative average used all...
<h3>Importance</h3> Recurrent stroke rates have decreased substantially in Western countries. However, data on changes recurrence and risk factor patterns China are limited. <h3>Objective</h3> To systematically assess trends by evaluating temporal improvement guideline-recommended secondary prevention treatment performance over 10 years China. <h3>Design, Setting, Participants</h3> This post hoc cohort study was conducted based from the National Stroke Registries (CNSRs, comprising 3 phases,...
Dual antiplatelet treatment has been shown to lower the risk of recurrent stroke as compared with aspirin alone when is initiated early (≤24 hours) after an acute mild stroke. The effect clopidogrel plus administered within 72 hours onset cerebral ischemia from atherosclerosis not well studied.
Abstract Objective To test the hypothesis that ticagrelor plus aspirin is safe and superior to clopidogrel for reducing high platelet reactivity at 90 days stroke recurrence in patients with minor or transient ischaemic attack, particularly carriers of CYP2C19 loss-of-function allele large artery atherosclerosis. Design Open label, blinded endpoint, randomised controlled phase II trial. Setting Prospective studies conducted 26 centres China, August 2015 March 2017. Participants 675 acute...
Background: The triglyceride glucose index (TyG index) has been proposed as a simple and credible surrogate marker of insulin resistance. However, it is unclear whether TyG correlates with adverse clinical outcomes in patients ischemic stroke. Accordingly, this study aimed to explore the relationship between baseline stroke individuals. Methods: We included eligible subjects from China National Stroke Registry II for current analysis. was calculated divided into quartiles Outcomes...
<h3>Importance</h3> In China and other parts of the world, hospital personnel adherence to evidence-based stroke care is limited. <h3>Objective</h3> To determine whether a multifaceted quality improvement intervention can improve performance measures in patients with acute ischemic (AIS) China. <h3>Design, Setting, Participants</h3> A multicenter, cluster-randomized clinical trial among 40 public hospitals that enrolled 4800 hospitalized AIS from August 10, 2014, through June 20, 2015,...
<h3>Importance</h3> Stroke represents a significant burden on the health care system of China. The Chinese Center Alliance was launched in 2015 to monitor and improve quality outcomes for patients with acute stroke transient ischemic attack (TIA). <h3>Objective</h3> To evaluate clinical characteristics, management, in-hospital complications among or TIA <h3>Design, Setting, Participants</h3> This improvement study assessed admissions 1476 participating hospitals between August 1, 2015, July...
Sex differences in stroke outcomes are crucial to secondary prevention, but previous reports showed inconsistent results. We aimed explore the sex Third China National Stroke Registry, a prospective multicenter registry study.Among 15 166 patients enrolled between 2015 and 2018, 9038 with acute ischemic (AIS) were included. The primary recurrence, mortality, unfavorable functional outcome (modified Rankin Scale > 2) at 3, 6, 12 months. Cox regression model was used for recurrence mortality...
Background and purpose Symptomatic internal carotid artery stenosis (sCAS) is an essential cause of transient ischaemic attack (TIA) or minor stroke. We aimed to evaluate whether the superiority aspirin-ticagrelor over aspirin-clopidogrel varies between patients with sCAS not. Methods This was a post-hoc analysis High-Risk Patients Acute Nondisabling Cerebrovascular Events-II (CHANCE-2) trial, all which were CYP2C19 loss-of-function alleles carriers. The primary exposures interest treatment...
Importance Trials have not demonstrated superiority of alteplase or tenecteplase vs standard care in patients with mild stroke and raised safety concerns. Prourokinase is an alternative fibrinolytic that may a favorable profile, the benefit-risk profile prourokinase unknown. Objective To investigate efficacy ischemic within 4.5 hours symptom onset. Design, Setting, Participants This was multicenter, prospective, open-label, blinded–end point randomized clinical trial conducted from November...
<h3>Importance</h3> Infarction patterns may serve as important imaging markers to assess the probability of stroke recurrence in transient ischemic attack (TIA) and minor stroke. However, it is unclear whether patients with different infarction benefit differently from dual antiplatelet therapy. <h3>Objectives</h3> To investigate can stratify risk recurrent efficacy safety clopidogrel plus aspirin vs alone are consistent after TIA or <h3>Design, Setting, Participants</h3> In this...
Background and Purpose— China bears a heavy burden of stroke because its large population elderly people the propensity for stroke. Previous studies have examined association between air pollution mortality or hospital admission. However, global evidence adverse effects on survival after is scarce. Methods— We used first national hospital-based prospective registry cohort in China, which included 12 291 ischemic patients who visited hospitals during 2007 to 2008. All were followed 1-year...
Background and Purpose Despite administration of evidence-based therapies, residual risk stroke recurrence persists. This study aimed to evaluate the recurrent in acute ischemic or transient attack (TIA) with adherence guideline-based secondary prevention identify factors risk.Methods Patients TIA within 7 hours were enrolled from 169 hospitals Third China National Stroke Registry (CNSR-III) China. Adherence was defined as persistently receiving all five medications (antithrombotic,...
Background and Purpose: It is still unclear whether the residual cholesterol inflammatory risk in acute phase associated with prognosis of stroke. We aimed to investigate proportion relative contribution risk, determined by baseline low-density lipoprotein (LDL-C) high-sensitivity C-reactive protein (hsCRP) levels, recurrent stroke poor functional outcome at 1 year. Methods: In this prospective multicenter cohort study, 10 499 consecutive ischemic transient attack patients levels LDL-C hsCRP...