A5083751614- Listeria monocytogenes in Food Safety
- Luminescence and Fluorescent Materials
- Vibrio bacteria research studies
- Molecular Sensors and Ion Detection
- Microbial Inactivation Methods
- Acute Ischemic Stroke Management
- Porphyrin and Phthalocyanine Chemistry
- Plant pathogens and resistance mechanisms
- Food Allergy and Anaphylaxis Research
- Enzyme Structure and Function
- Microbial bioremediation and biosurfactants
- Cerebrovascular and Carotid Artery Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Cellulose Research Studies
- Sunflower and Safflower Cultivation
- Bacterial biofilms and quorum sensing
- Essential Oils and Antimicrobial Activity
- Soybean genetics and cultivation
- Ginseng Biological Effects and Applications
- Pineapple and bromelain studies
- Pesticide and Herbicide Environmental Studies
- Gut microbiota and health
- Food Industry and Aquatic Biology
- Polysaccharides and Plant Cell Walls
- Enzyme-mediated dye degradation
Inner Mongolia Agricultural University
2024-2025
Huazhong University of Science and Technology
2008-2024
Purdue University West Lafayette
2018-2024
Hejian People's Hospital
2023-2024
Beijing Institute of Fashion Technology
2024
Harbin University of Commerce
2023
China Medical University
2021
Xinxiang Medical University
2020
University of Massachusetts Chan Medical School
2019
Tianjin University
2016-2019
Dual antiplatelet treatment has been shown to lower the risk of recurrent stroke as compared with aspirin alone when is initiated early (≤24 hours) after an acute mild stroke. The effect clopidogrel plus administered within 72 hours onset cerebral ischemia from atherosclerosis not well studied.
Abstract Objectives To assess the efficacy and safety of colchicine versus placebo on reducing risk subsequent stroke after high non-cardioembolic ischaemic or transient attack within first three months symptom onset (CHANCE-3). Design Multicentre, double blind, randomised, controlled trial. Setting 244 hospitals in China between 11 August 2022 13 April 2023. Participants 8343 patients aged 40 years age older with a minor-to-moderate sensitivity C-reactive protein ≥2 mg/L were enrolled....
The emergence of bacterial resistance to therapeutic antibiotics limits options for treatment common microbial diseases. Subinhibitory dosing, often aid in the resistance, but its impact on pathogen's physiology and pathogenesis is not well understood. Here we investigated effect tunicamycin, a cell wall teichoic acid (WTA) biosynthesis inhibiting antibiotic at subinhibitory dosage Staphylococcus aureus Listeria monocytogenes physiology, cross-resistance, biofilm-formation, virulence....
Abstract Probiotic bacteria reduce the intestinal colonization of pathogens. Yet, their use in preventing fatal infection caused by foodborne Listeria monocytogenes ( Lm ), is inconsistent. Here, we b ioengineered L actobacillus p robiotics (BLP) to express adhesion protein (LAP) from a non-pathogenic L. innocua ) and pathogenic on surface Lactobacillus casei . The BLP strains colonize intestine, mucosal systemic dissemination, protect mice lethal infection. competitively excludes occupying...
ABSTRACT The cellular junctional architecture remodeling by Listeria adhesion protein-heat shock protein 60 (LAP-Hsp60) interaction for monocytogenes ( Lm ) passage through the epithelial barrier is incompletely understood. Here, using gerbil model, permissive to internalin (Inl) A/B-mediated pathways like in humans, we demonstrate that crosses intestinal villi at 48 h post-infection. In contrast, single isogenic lap − or Δ inlA double mutant strains show significant defects. LAP promotes...
Comparisons are limited for immediate-intensive and delayed-intensive statin secondary stroke prevention neuroprotection in patients with acute mild ischemic or transient attack (TIA) from atherosclerosis.
Environmental cues promote microbial biofilm formation and physiological genetic heterogeneity. In food production facilities, biofilms produced by pathogens are a major source for contamination; however, the pathogenesis of biofilm-isolated sessile cells is not well understood. We investigated Listeria monocytogenes (Lm) using cell culture mouse models. Lm express reduced levels lap, inlA, hly, prfA, sigB show adhesion, invasion, translocation, cytotoxicity in model than planktonic cells....
Dioxygenases catalyze dioxygen incorporation into various organic compounds and play a key role in the complex degradation pathway of mono- polycyclic aromatic hetero-aromatic compounds. Here we report crystal structure gentisate 1,2-dioxygenase from Silicibacter pomeroyi (GDOsp) at 2.8 A resolution. The enzyme possessed conserved three-dimensional bicupin family, forming homotetramerization. However, each subunit GDOsp unusually contained two ferrous centers that were located its homologous...
Listeria adhesion protein (LAP) is a secreted acetaldehyde alcohol dehydrogenase (AdhE) that anchors to an unknown molecule on the monocytogenes (Lm) surface, which critical for its intestinal epithelium crossing. In present work, immunoprecipitation and mass spectrometry identify internalin B (InlB) as primary ligand of LAP (KD ∼ 42 nM). InlB-deleted naturally InlB-deficient Lm strains show reduced LAP-InlB interaction LAP-mediated pathology in murine intestine brain invasion....
Liver cirrhosis is the late stage of hepatic fibrosis and characterized by portal hypertension that can clinically lead to decompensation in form ascites, esophageal/gastric varices or encephalopathy. The most common sequelae associated with liver are neurologic neuropsychiatric impairments labeled as encephalopathy (HE). Well established triggers for HE include infection, gastrointestinal bleeding, constipation, medications. Alterations gut microbiome one leading ammonia producers body,...
Numerous interacting protein partners exist without recognized interactive domains, necessitating a standardized methodology to decipher more in-depth interaction profiles. Here, we present protocol reveal the binding partner of secreted housekeeping enzyme, alcohol acetaldehyde dehydrogenase (Listeria adhesion protein), in Listeria monocytogenes through silico modeling and vivo experiments. We describe steps for target modeling, biophysical profiling, ClusPro docking optimization, variant...
Sunflower (Helianthus annuus) is one of the most important economic crops in oilseed production worldwide. The different cultivars exhibit variability their resistance genes. NAC transcription factor (TF) family plays diverse roles plant development and stress responses. With completion H. annuus genome sequence, entire complement genes coding for NACs has been identified. However, reference a single individual cannot cover all genetic information species.
Atrial fibrillation (AF) is the most common cardiac arrhythmia in world and AF predominantly affects older individuals. Smart devices, including phones watches, offer potential as mechanisms to detect facilitate its treatment, but individuals, late-adopters of technology, may not perceive smart devices easy or important use. Our study focused on assessing impressions for heart rhythm monitoring ambulatory patients presenting a cardiology practice.