A5101544987- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Visual perception and processing mechanisms
- Traditional Chinese Medicine Analysis
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Glaucoma and retinal disorders
- Stroke Rehabilitation and Recovery
- Ferroptosis and cancer prognosis
- Biochemical effects in animals
- Parkinson's Disease Mechanisms and Treatments
- Vasculitis and related conditions
- Parkinson's Disease and Spinal Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Ophthalmology and Eye Disorders
- Amino Acid Enzymes and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ginseng Biological Effects and Applications
Liaocheng People's Hospital
2015-2025
Shandong First Medical University
2023-2024
Cardiff University
2023
Taishan Medical University
2017-2018
Comparisons between ticagrelor and clopidogrel for the secondary prevention of stroke in CYP2C19 loss-of-function carriers have not been extensively performed.
Abstract Objectives To assess the efficacy and safety of colchicine versus placebo on reducing risk subsequent stroke after high non-cardioembolic ischaemic or transient attack within first three months symptom onset (CHANCE-3). Design Multicentre, double blind, randomised, controlled trial. Setting 244 hospitals in China between 11 August 2022 13 April 2023. Participants 8343 patients aged 40 years age older with a minor-to-moderate sensitivity C-reactive protein ≥2 mg/L were enrolled....
Importance Preclinical and clinical studies have suggested the neuroprotective effect of Panax notoginseng saponins (Xuesaitong soft capsules). However, robust evidence in patients with ischemic stroke is lacking. Objective To assess efficacy safety Xuesaitong capsules stroke. Design, Setting, Participants This multicenter, double-blind, placebo-controlled randomized trial was conducted at 67 tertiary health centers China from July 1, 2018, to June 30, 2020. Included were aged 18 75 years a...
Importance Trials have not demonstrated superiority of alteplase or tenecteplase vs standard care in patients with mild stroke and raised safety concerns. Prourokinase is an alternative fibrinolytic that may a favorable profile, the benefit-risk profile prourokinase unknown. Objective To investigate efficacy ischemic within 4.5 hours symptom onset. Design, Setting, Participants This was multicenter, prospective, open-label, blinded–end point randomized clinical trial conducted from November...
Objectives: We investigated postural sway in patients with early Parkinson's disease (PD) to test the hypothesis that control system was affected already at an stage of PD. Moreover, we identified cases dysfunction stereopsis PD patients. Methods: examined 23 and healthy, sex- age-matched subjects. Postural measured accelerometer center mass lower spine. Subjects were asked stand quietly for 30 s under two usual conditions (eyes open eyes closed) dual tasks task, closed task). Stereopsis...
The metabolic syndrome (MetS) is related with cardiovascular disease. However, its relationship diabetes mellitus (DM) has not been examined in Chinese population a larger sample. We aimed to assess the between and components, DM, determine best one from available definitions of Mets when assessing risk DM.This was cross-sectional survey nationally representative sample 109,551 adults aged ≥40 years 2014-15. MetS defined according three criteria including updated International Diabetes...
The pathogenesis of Alzheimer's disease (AD) is complex and multi-factorial. Increasing evidence has shown the important role immune infiltration in AD. Thus current study was designed to identify infiltration-related genes explore their diagnostic value AD.The expression data AD patients were downloaded from GEO database. limma R package identified differentially expressed (DEGs) between controls. CIBERSORT algorithm infiltrated cells (DIICs) DIIC-correlated DEGs obtained by Pearson...
Forkhead box protein subfamily P (FOXP) 1 has an important role in the control of gene transcription and is also reported to function as a tumor suppressor. The aim present study was explore regulatory mechanisms atherosclerosis by investigating microRNA‑206 (miR‑206) association between miR‑206 its potential target gene, FOXP1, vascular smooth muscle cells (VSMCs). Bioinformatics tools were utilized identify FOXP1 miR‑206. Luciferase reporter analysis used confirm this relationship binding...
<b><i>Objective:</i></b> Neuroinflammation plays an important role in secondary tissue damage after traumatic brain injury (TBI). Recently, the inflammasome-mediated inflammatory pathway has been observed response of TBI. In this study, we investigated influence hyperbaric oxygen therapy (HBOT) on inflammasome activation <b><i>Methods:</i></b> The experimental mice were randomly divided into 4 groups as follows: sham-operated normobaric air...
Abstract The slow-developing neurological disorder Alzheimer’s disease (AD) has no recognized etiology. A bioinformatics investigation verified copper metabolism indicators for AD development. GEO contributed AD-related datasets GSE1297 and GSE5281. Differential expression analysis WGCNA confirmed biomarker candidate genes. Each immune cell type in control samples was scored using single sample gene set enrichment analysis. Receiver Operating Characteristic (ROC) analysis, short Time-series...
Emerging evidence has shown that Long noncoding RNAs (LncRNAs) are aberrantly expressed and functionally involved in the development of neurodegenerative disorders. In this work, we investigated regulatory effects lncRNA LINC01311 its competing endogenous RNA target hsa-miR-146a-5p a cellular model Alzheimer's disease (AD). SH-SY5Y cells were treated with synthetic Βeta-Amyloid Peptide (1-42) (AB1-42) vitro to induce AD-like neural injuries. Expressions monitored by qRT-PCR. was upregulated...
Background/Aims: Hypersensitive pain response is often observed in patients with Parkinson's disease (PD); however, the mechanisms responsible for hyperalgesia are not well understood. Chronic neuroinflammation one of hallmarks PD pathophysiology. Since midbrain periaqueductal gray (PAG) an important component descending inhibitory pathway controlling on central transmission, we examined role pro-inflammatory cytokines (PICs) system PAG regulating exaggerated evoked by PD. Methods: We used a...
Alzheimer's disease (AD) is often associated with declined visual processing abilities. Here we tested whether the functions of center-surround suppression- a hallmark property in system- are altered by AD. To this end, recruited three groups participants (AD, elderly, and young) motion direction discrimination task, which measured temporal duration threshold drifting Gabor varying stimulus sizes. We first replicated phenomena suppression that required for discriminating high contrast...
The results on the role of systolic blood pressure (SBP) variability in functional outcome for patients with intracerebral hemorrhage (ICH) have been inconsistent. Hence, this meta-analysis prospective studies was conducted to assess association between SBP and poor outcomes acute or subacute ICH. PubMed, Embase, Cochrane Library were electronically searched eligible from their inception July 2020. assessed using standard deviation (SD), coefficient variation (CV), successive (SV), average...
Our perception of the world is remarkably stable despite distorted retinal input due to frequent eye movements. It considered that brain uses corollary discharge, efference copies signals sent from motor visual regions, compensate for distortions and stabilize perception. In this study, we tested whether patients with Alzheimer's disease (AD) have impaired discharge functions as evidenced by reduced compensation during optic flow mimics self-motion in environment. We asked a group...
Preclinical studies have indicated that Angong Niuhuang Pills (ANP) reduce cerebral infarct and edema volumes. This study aimed to investigate whether ANP safely reduces volumes in patients with moderate severe acute ischemic stroke. randomized, double-blind, placebo-controlled pilot trial included stroke National Institutes of Health Stroke Scale (NIHSS) scores ranging from 10 20 17 centers China between April 2021 July 2022. Patients were allocated within 36 h after onset via block...
Objective To observe the effect of dual-task interference on postural sway and hand flexibility patients with early Parkinson's disease(PD). Methods Twenty-tree PD twenty-three healthy, sex-and age-matched control subjects were examined. Postural was measured an accelerometer at centre mass lower spine.Two parameters computed from acceleration signals including root mean square acceleration(RMS) jerkiness sway(JERK). Purdue pegboard test, single-task tests test performed respectively...
Objective To explore the relationship between serum anticardiolipin antibody (ACA), vascular endothelial grow factor (VEGF) concentration and cognitive impairment in patients with ischemic stroke. Methods Totally 128 cases acute stroke were admmitted unit ward of our hospital during June 2014 to December 2014. According score Montreal assessment (MoCA), divided into groups A (53 impairment) group B (75 without impairment). The concentrations ACA, VEGF quantitatively determinated by...
Abstract Introduction hCNT (Human Concentrative Nucleoside Transporter, also known as SLC28A1) and hENT Equilibrative SLC29A1) belong to the large solute carrier (SLC) family, a membrane transport molecule group for influx efflux across cell of various solutes including some anticancer drugs. are suggested be involved in transportation certain chemotherapeutic The present study investigated role both transporters gastric cancer response patients Methods expression levels gene transcripts...
Objective To explore the relationship between serum anticardiolipin antibody-immune globulin G (ACA-IgG), interleukin-17 (IL-17) and high-sensitivity C-reactive protein (hsCRP) concentration intracerebral artery stenosis middle cerebral atherosclerotic stenosis. Methods By digital subtraction angiography (DSA), 78 patients with ischemic cerebrovascular disease were enrolled divided into a stenosis-free group(21 cases), mild-stenosis group (n=22), moderate-stenosis (n=18),...