A5100703942- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Drug-Induced Hepatotoxicity and Protection
- Traditional Chinese Medicine Studies
- Respiratory Support and Mechanisms
- Pharmacological Effects of Natural Compounds
- Medical Research and Treatments
- Cancer-related molecular mechanisms research
- Phytochemistry and biological activity of medicinal plants
- Marine Toxins and Detection Methods
- Ferroptosis and cancer prognosis
- Asthma and respiratory diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Hair Growth and Disorders
- Metabolomics and Mass Spectrometry Studies
- Dermatologic Treatments and Research
- Pharmacogenetics and Drug Metabolism
- Acupuncture Treatment Research Studies
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Complementary and Alternative Medicine Studies
- High Altitude and Hypoxia
- Cerebrovascular and Carotid Artery Diseases
- Healthcare and Venom Research
Xinjiang Uygur Autonomous Region Uygur Medicine Hospital
2023-2024
Xinjiang Medical University
2013-2024
Chinese PLA General Hospital
2019-2024
Sichuan University
2024
Blind and Sight Impaired Society
2024
Anhui Agricultural University
2021-2024
Hubei Cancer Hospital
2016-2023
Huazhong University of Science and Technology
2023
People's Hospital of Xinjiang Uygur Autonomous Region
2022
Shanghai University of Sport
2022
Previous randomized clinical trials did not demonstrate the superiority of endovascular stenting over aggressive medical management for patients with symptomatic intracranial atherosclerotic stenosis (sICAS). However, balloon angioplasty has been investigated in a trial.
Abstract Background The study investigated the effects and underlying mechanisms of intestinal flora metabolite butyrate on inflammatory ILC2 cells (iILC2s)-mediated lung inflammation in chronic obstructive pulmonary disease (COPD). Methods Mouse models COPD acute exacerbation (AECOPD) were established. Flow cytometry was used to detect natural (nILC2s) iILC2s colon tissues. 16s rRNA GC-MS microbial short chain fatty acids (SCFAs) feces. ELISA IL-13 IL-4. Western blot qRT-PCR relative...
Group 2 innate lymphoid cells (ILC2) strongly modulate COPD pathogenesis. However, the significance of microbiota in ILC2s remains unelucidated. Herein, we investigated immunomodulatory role short-chain fatty acids (SCFAs) regulating ILC2-associated airway inflammation and explores its associated mechanism COPD. In particular, assessed SCFA-mediated regulation survival, proliferation, cytokine production lung sorted ILC2s. To elucidate butyrate action ILC2-driven inflammatory response...
Mushrooms have limited shelf-life and it can be prolonged if suitable conditions treatments are effectively applied. In this study, nanocomposite material antimicrobial agents with a combination of chitosan were used as novel packaging for mushroom preservation. The microbiological analysis, physicochemical properties, headspace gas polyphenol oxidase activity (PPO) during cold storage investigated. As compared control, coated mushrooms (CHS), nano-titanium dioxide CHSTiO2 thymol + tween-80...
Dried blood spots (DBSs) provide a valuable complementary sample matrix for routine doping analysis, and the full automation of analysis DBS samples is achievable to avoid extensive repetitive manual laboratory work. In current study, fully automated online preparation detection method screening quantification 13 anabolic steroid esters by means DBSA-TLX-HRMS system was developed validated, based on purpose determination abuse in athletes. Validation yielded linear (R2 > 0.99), precise,...
Decorin is a prototypical member of the small leucine-rich proteoglycan (SLRP) family, which involved in numerous biological processes. The role decorin, as representative SLRP, hair follicle morphogenesis has not been elucidated. We present our initial findings on decorin expression patterns during induced murine (HF) cycles. It was found that exclusively restricted to epidermis, outer root sheath and sebaceous glands anagen phase, correlates with upregulation mRNA protein depilated dorsal...
Drug-induced liver injury (DILI), defined as caused by a drug and/or its metabolites, is common clinical adverse reaction1, 2, 3, 4. This type of can cause acute failure and even death in severe cases5. DILI accounts for many warnings an important the development new drugs forms traditional Chinese medicine (TCM). Thus, from has attracted close attention medical professionals, pharmaceutical industry, general public6, 7, 8. For thousands years, TCM contributed to prevention treatment...
Domoic acid (DA) is a marine neurotoxin produced by several species of Pseudo-nitzschia. DA causes severe neurological toxicity in humans and animals. To address the current analytical need to quantify low levels human animal body fluids, sensitive selective high performance liquid chromatography-tandem mass spectrometry method was developed measure plasma urine. This fully validated accurately precisely between 0.31 16 ng/mL 7.8 1000 Our group introduced use novel internal standard,...
Excessive activation of M1 macrophages affects the chronic inflammatory response airways and leads to development obstructive pulmonary disease (COPD). Therefore, it needs be closely monitored investigated. MAPK signaling pathway is involved in macrophages, N6-methyladenosine (m6A) pathogenesis COPD. However, unknown whether mediated by m6A COPD.The GEO data were analyzed using bioinformatics techniques assess differences between COPD healthy individuals levels their secreted cytokines,...
This study is to investigate the capacity of type 2 innate lymphoid cells (ILC2s) in regulating Th2 adaptive immune response acute exacerbation chronic obstructive pulmonary disease (AECOPD). The enrolled healthy people, stable (COPD) patients, and AECOPD patients. Flow cytometry was used detect ILC2 peripheral blood. In addition, ILC2s from blood patients were stimulated with PBS, IL-33, Jagged1, DAPT, IL-33+Jagged1, IL-33+DAPT, IL-33+Jagged-1+DAP vitro. levels cytokines culture supernatant...
Xiaoqinglong decoction (XQLD) is 1 of the traditional Chinese medicine (TCM) classic herbal formula that widely used in Asian for acute exacerbation chronic obstructive pulmonary disease (AECOPD). In recent years, there has been increasing interest use XQLD to treat COPD China. So it necessary update research and re-evaluate efficacy safety provide up-to-date evidence management. Therefore, we a protocol systematic review COPD. This described investigate beneficial effects AECOPD.A...
In traditional Chinese medicine (TCM), the Yiqigubiao pill is commonly used to enhance physical fitness. The current clinical trial was designed evaluate efficacy and safety of as an adjuvant therapy for patients with stable chronic obstructive pulmonary disease (COPD). a randomized, double‑blind, placebo‑controlled superiority trial. participants were recruited from outpatients at Traditional Medicine Hospital affiliated Xinjiang Medical University (Ürümqi, China) between February September...
The interaction between immune checkpoint and myeloid-derived suppressor cells (MDSCs) play a significant role in inflammatory diseases. But their correlation with chronic obstructive pulmonary disease (COPD) remains unclear.The differentially expressed checkpoints immunocytes the airway tissues of COPD patients were identified by bioinformatics analysis, followed analysis identification immune-related differential genes for Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO)...