A5100318864- Advanced Frequency and Time Standards
- Cerebrovascular and Carotid Artery Diseases
- Atomic and Subatomic Physics Research
- Hepatitis B Virus Studies
- Advanced Fiber Laser Technologies
- Pneumonia and Respiratory Infections
- Cold Atom Physics and Bose-Einstein Condensates
- Antibiotic Resistance in Bacteria
- Aortic aneurysm repair treatments
- Respiratory Support and Mechanisms
- Acute Ischemic Stroke Management
- Lung Cancer Treatments and Mutations
- Intracranial Aneurysms: Treatment and Complications
- Quantum optics and atomic interactions
- Aortic Disease and Treatment Approaches
- Streptococcal Infections and Treatments
- Bacterial biofilms and quorum sensing
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Bacterial Identification and Susceptibility Testing
- Hepatitis C virus research
- Antimicrobial Resistance in Staphylococcus
- Nanoplatforms for cancer theranostics
- Network Traffic and Congestion Control
Shanghai East Hospital
2025
Hebei Medical University
2020-2025
Xingtai People's Hospital
2020-2025
Tsinghua University
2015-2024
National Center for Chronic and Noncommunicable Disease Control and Prevention
2013-2024
Wuhan University
2017-2024
Second Affiliated Hospital of Nanchang University
2021-2024
Nanchang University
2021-2024
Jiangsu Cancer Hospital
2016-2024
Peking University Cancer Hospital
2016-2024
IntroductionSintilimab, an anti–programmed death 1 antibody, plus pemetrexed and platinum had revealed promising efficacy for nonsquamous NSCLC in a phase 1b study. We conducted randomized, double-blind, 3 study to compare the safety of sintilimab with placebo, both combination such chemotherapy (ClinicalTrials.gov: NCT03607539).MethodsA total 397 patients previously untreated, locally advanced or metastatic without sensitizing EGFR anaplastic lymphoma kinase genomic aberration were...
Polysaccharide capsule is the main virulence factor of K . pneumoniae , a major pathogen bloodstream infections in humans. While more than 80 capsular serotypes have been identified only several are frequently invasive infections. It documented that enhances bacterial resistance to phagocytosis, antimicrobial peptides and complement deposition under vitro conditions. However, precise role process remains be elucidated. Here we show promotes survival by protecting bacteria from being captured...
While calcium-overload-mediated therapy (COMT) is a promising but largely untapped therapeutic strategy, combinatory greatly boosts treatment outcomes with integrated merits of different therapies. Herein, BPQD@CaO2 -PEG-GPC3Ab nanoplatform formulated by integrating calcium peroxide (CaO2 ) and black phosphorus quantum dot (BPQD, photosensitizer) active-targeting glypican-3 antibody (GPC3Ab), for photodynamic (PDT) COMT in response to acidic pH near-infrared (NIR) light, wherein CaO2 serves...
<h3>Objective</h3> To investigate whether elevated plasma trimethylamine N-oxide (TMAO) levels are associated with initial stroke severity and infarct volume. <h3>Methods</h3> This cross-sectional study included 377 patients acute ischemic 50 healthy controls. Plasma TMAO were assessed at admission. Stroke size clinical measured diffusion-weighted imaging the NIH Scale (NIHSS). Mild was defined as an NIHSS score <6. <h3>Results</h3> higher in than controls (median 5.1 vs 3.0 μmol/L;...
Abstract Background Treatment options for Chinese patients with locally advanced or metastatic squamous‐cell non‐small‐cell lung cancer (sqNSCLC) after failure of first‐line chemotherapy are limited. This study (ORIENT‐3) aimed to evaluate the efficacy and safety sintilimab versus docetaxel as second‐line treatment in sqNSCLC. Methods ORIENT‐3 was an open‐label, multicenter, randomized controlled phase 3 trial that recruited stage IIIB/IIIC/IV sqNSCLC platinum‐based chemotherapy. Patients...
Hypermucoviscosity is a hallmark of hypervirulent Klebsiella pneumoniae (hvKP). However, the molecular basis its regulation largely unknown. We hypothesize that hypermucoviscosity modulated via two-component signal transduction systems (TCSs). In-frame deletion mutants all 33 response regulators hvKP ATCC43816 were generated using CRISPR/CAS and evaluated for their impacts on hypermucoviscosity. The regulator OmpR required
Streptococcus pneumoniae, the leading pathogen of bacterial infections in infants and elderly, is responsible for pneumococcal diseases with severe morbidity mortality. Emergence drug-resistant strains presented new challenges treatment prevention. Vaccination has proven to be an effective means preventing infection worldwide. Detailed epidemiological information antibiotic susceptibilities serotype distribution will great help management infections. A total 881 S. pneumoniae isolates were...
NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is an important component of the innate immune system that mediates secretion pro-inflammatory cytokines interleukin-1β (IL-1β) IL-18. However, current studies have shown abnormal activation NLRP3 associated with inflammatory diseases such as atherosclerosis, diabetes, pneumonia. In this study, we found canagliflozin (CAN) transcriptionally inhibited inflammasome-related proteins by inhibiting transduction nuclear factor...
This study aims to perform a comprehensive bibliometric analysis of global research on BRAF and MEK inhibitor resistance in melanoma, identifying key trends, influential contributors, emerging themes from 2003 2024. A systematic search was conducted the Web Science Core Collection (WoSCC) database retrieve publications related 1 January 2003, September Bibliometric analyses, including publication citation networks, keyword co-occurrence patterns, were performed using VOSviewer CiteSpace....
Importance Trials have not demonstrated superiority of alteplase or tenecteplase vs standard care in patients with mild stroke and raised safety concerns. Prourokinase is an alternative fibrinolytic that may a favorable profile, the benefit-risk profile prourokinase unknown. Objective To investigate efficacy ischemic within 4.5 hours symptom onset. Design, Setting, Participants This was multicenter, prospective, open-label, blinded–end point randomized clinical trial conducted from November...
Precision determination of the hyperfine splitting cadmium ions is essential to study space-time variation fundamental physical constants and isotope shifts. In this work, we present precision frequency measurement excited-state $^2{P}_{3/2}$ $^{111,113}\mathrm{Cd}^+$ using laser-induced fluorescence technique. By introducing technology sympathetic cooling setting up free-space beat detection unit based on optical comb, uncertainties are improved 14.8 kHz 10.0 kHz, respectively, two orders...
Background Acute respiratory distress syndrome ( ARDS ) is a critical condition characterized by bilateral pulmonary infiltrates and severe hypoxemia. This study aimed to evaluate the diagnostic prognostic values of Club cell protein 16 CC 16) in care patients with . Methods In this retrospective observational study, 83 129 non‐ on ICU admission were enrolled. The differences serum other laboratory indicators between two groups analyzed. sensitivity, specificity, positive negative predictive...
Listeriosis, caused by Listeria monocytogenes , is a severe food-borne infection. The nationwide surveillance in China concerning listeriosis urgently needed. In the present study, 144 L. isolates were collected from samples of blood, cerebrospinal fluid (CSF), and fetal membrane/placenta for 12 years 2008 to 2019. We summarized these patients’ demographical clinical features outcomes. susceptibility profile antibiotics was also determined broth microdilution method. Multilocus sequence...
Idiopathic pulmonary arterial hypertension (IPAH) is a rare vascular disease with poor prognosis, and the mechanism of its development remains unclear. Further molecular pathology studies may contribute to comprehensive understanding IPAH provide new insights into diagnostic markers potential therapeutic targets. Iron deficiency has been reported in 43-63% patients associated reduced exercise capacity higher mortality, suggesting that dysregulated iron metabolism play an unrecognized role...
Time delay estimation (TDE) is an important step to identify and locate vibration source. The TDE result can be obtained by cross-correlation method through seeking the maximum correlation peak of two signals. However, will induce random error when dealing with nonstationary signal. We propose a novel time shifting deviation (TSDEV) solve this problem, which has been proved achieve ultrahigh precision localization in fiber monitoring system. This paper compares TSDEV detail simulating...
Acquired drug resistance decreases the efficacy of gefitinib after approximately 1 year treatment in non-small-cell lung cancer (NSCLC). Autophagy is a process that could lead to cell death when it prolonged. Thus, we investigated combination therapy with rapamycin-a autophagy activator-in gefitinib-resistant NSCLC line H1975 improve therapeutic advanced cells through acute induction. Cell viability and tumor formation assays indicated rapamycin strongly synergistic inhibition, both vitro...