A5103250568- Parasites and Host Interactions
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- High Altitude and Hypoxia
- Neurotransmitter Receptor Influence on Behavior
- Immune cells in cancer
- Tryptophan and brain disorders
- Macrophage Migration Inhibitory Factor
- Stress Responses and Cortisol
- Research on Leishmaniasis Studies
- Liver physiology and pathology
- Trypanosoma species research and implications
- Kruppel-like factors research
- Liver Diseases and Immunity
- Intracerebral and Subarachnoid Hemorrhage Research
- Eicosanoids and Hypertension Pharmacology
- Autophagy in Disease and Therapy
- Acute Ischemic Stroke Management
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Adrenal Hormones and Disorders
- Kawasaki Disease and Coronary Complications
- Inflammation biomarkers and pathways
Emissions Reduction Alberta
2023
Fuyang City People's Hospital
2020
Nanjing University of Chinese Medicine
2019
The University of Texas Medical Branch at Galveston
2014-2017
Zhejiang University
2014-2016
John Sealy Hospital
2015
High-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but exact mechanisms underlying HACE are not fully understood. Human volunteers ascended to high altitude (3860 m, 2 days), rats were exposed hypoxia in a hypobaric chamber (5000 days). was evaluated by Lake Louise Score (LLS), plasma corticotrophin-releasing hormone (CRH) cytokines TNF-α, IL-1β, IL-6 measured humans. Subsequently,...
The airway epithelial cell plays a central role in coordinating the pulmonary response to injury and inflammation. Here, transforming growth factor-β (TGFβ) activates gene expression programs induce stem cell-like properties, inhibit of differentiated adhesion proteins express mesenchymal contractile proteins. This process is known as transition (EMT); although much about EMT cellular metastasis an oncogene-transformed cell, less Type II EMT, that occurring normal cells. In this study, we...
Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is characterized relentlessly increasing visceral parasite replication, cachexia, massive splenomegaly, pancytopenia and ultimately death. Progressive disease considered to be due impaired effector T cell function and/or failure of macrophages activated kill parasite. In previous studies, we used Syrian hamster (Mesocricetus auratus) as a model because it mimics progressive nature active human VL. We...
Significance High-altitude cerebral edema, a serious and often fatal condition, results from lowered oxygen supply. This study explores the mechanisms by which hypoxia induces edema. We show that induced edema neuronal apoptosis associated with increased expression of neuropeptide corticotrophin releasing factor (CRF) its type 1 receptor (CRFR1), water channel aquaporin-4 (AQP4), endothelin-1; these effects could be blocked CRFR1 antagonist. In cultured astrocytes, CRF, acting through CRFR1,...
There exists much variability in susceptibility/resilience to addiction humans. The environmental enrichment paradigm is a rat model of resilience addiction-like behavior, and understanding the molecular mechanisms underlying this protective phenotype may lead novel targets for pharmacotherapeutics treat cocaine addiction. We investigated differential regulation transcript levels using RNA sequencing nucleus accumbens after enrichment/isolation cocaine/saline self-administration. Ingenuity...
Importance Trials have not demonstrated superiority of alteplase or tenecteplase vs standard care in patients with mild stroke and raised safety concerns. Prourokinase is an alternative fibrinolytic that may a favorable profile, the benefit-risk profile prourokinase unknown. Objective To investigate efficacy ischemic within 4.5 hours symptom onset. Design, Setting, Participants This was multicenter, prospective, open-label, blinded–end point randomized clinical trial conducted from November...
Visceral leishmaniasis (VL), caused by infection with the intracellular protozoan Leishmania donovani, is a chronic progressive disease relentlessly increasing parasite burden in spleen, liver and bone marrow. The characterized fever, splenomegaly, cachexia, pancytopenia, progresses to death if not treated. Control of mediated Th1 (IFNγ-producing) CD4+ T cells, which activate macrophages produce nitric oxide kill parasites. However, despite expansion cells increased IFNγ expression humans...
The activation of hepatic stellate cells (HSCs) is a key event in fibrotic pathogenesis. However, the mechanism involving HSCs chronic schistosomiasis not entirely clear. Human HSC LX‐2 and human umbilical vein endothelial (ECs) were cultured with Schistosoma japonicum antigens (SA) vitro . Fibrosis‐associated genes cell proliferation analyzed. isolated from mice or without praziquantel (PZQ) treatment, followed by microarray analysis for liver fibrosis‐associated pathways. Although SA...
Prior research demonstrated that environmental enrichment creates individual differences in behavior leading to a protective addiction phenotype rats. Understanding the mechanisms underlying this will guide selection of targets for much-needed novel pharmacotherapeutics. The current study investigates proteome expression nucleus accumbens enriched and isolated rats proteomic response cocaine self-administration using liquid chromatography mass spectrometry (LCMS) technique quantify 1917...
The disruption of the blood brain barrier (BBB) is key factor leading to neurological impairment after intracerebral hemorrhage (ICH) injury. Adiponectin receptor 1 (AdipoR1) has an important effect contributing integrity BBB. As a homologue adiponectin, recombinant C1q/TNF-related protein 9 (rCTRP9) neuroprotective in cerebrovascular diseases. aim this study was investigate protective AdipoR1 activation with rCTRP9 on BBB ICH injury and potential mechanisms.177 male mice were subjected...
We have shown that hypoxia reduces plasma insulin, which correlates with corticotropin-releasing hormone (CRH) receptor 1 (CRHR1) in rats, but the mechanism remains unclear. Here, we report hypobaric at an altitude of 5,000 m for 8 h enhances rat CRH, corticosterone, and glucose levels, whereas insulin pancreatic ATP/ADP ratio is reduced. In islets cultured under normoxia, CRH stimulated release a glucose- CRH-level–dependent manner by activating CRHR1 thus cAMP-dependent protein kinase...
Deltonin, an active component extracted from Dioscorea zingiberensis C.H. WRIGHT, was widely utilized in traditional Chinese medicines. It has been shown to have anti-cancer functions such as colon cancer, breast and head neck squamous carcinoma. Herein, we will investigate the role of deltonin cerebral ischemia/reperfusion injuries.Ly294002 anisomycin were used inhibitors monitor effects deltonin. Middle artery occlusion I/R model constructed. Infarct volumes, neurological deficits brain...
BACKGROUND:This study aims to demonstrate the underlying correlation between resolution of liver fibrosis induced by Gexia-Zhuyu decoction (GZD) treatment and myeloid cell-mediated angiogenesis. MATERIAL AND METHODS:A mouse model carbon tetrachloride (CCl4) intervention was employed in this study. Dynamics blood function parameters were followed. The pathology detected Sirius Red Masson staining. Matrix metalloproteinase (MMP) 2/9, tissue inhibitors (TIMP)-1/2, vascular endothelial growth...
Abstract The homeobox encodes a DNA-binding domain found in transcription factors regulating key developmental processes. most notable examples of containing genes are the Hox genes, arranged on chromosomes same order as their expression domains along body axis. mechanisms responsible for synchronous regulation and molecular function colinearity remain unknown. Here we report discovery conserved structural signature 180-base pair DNA fragment comprising homeobox. We demonstrate that has...
ISHS XXVIII International Horticultural Congress on Science and Horticulture for People (IHC2010): Symposium Genomics Genetic Transformation of Crops IDENTIFICATION OF GENES AND GENE MARKERS BY GENOMICS, GENOME MAPPING COMPARATIVE PROTEOMICS THEIR RELATIONSHIP TO POTATO TUBER QUALITIES