A5100698882- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Neuroscience of respiration and sleep
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Light effects on plants
- Pulmonary Hypertension Research and Treatments
- Plant Genetic and Mutation Studies
- Adipose Tissue and Metabolism
- Thermal Regulation in Medicine
- Plant Disease Resistance and Genetics
- RNA modifications and cancer
- Seed Germination and Physiology
- Leaf Properties and Growth Measurement
- Research in Cotton Cultivation
- Heme Oxygenase-1 and Carbon Monoxide
- Greenhouse Technology and Climate Control
- GABA and Rice Research
- Eicosanoids and Hypertension Pharmacology
- Bamboo properties and applications
- Biochemical effects in animals
- Agriculture, Soil, Plant Science
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Neurological Disease Mechanisms and Treatments
Army Medical University
2014-2024
Southwest University of Science and Technology
2024
China Agricultural University
2024
Guizhou University
2008-2022
Army Medical College
2020
Chinese People's Liberation Army
2017
Chinese University of Hong Kong
2009-2014
Southwest Hospital
2013
Jilin Provincial Academy of Forestry Science
2010
Jiangsu Academy of Agricultural Sciences
2003-2005
High-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but exact mechanisms underlying HACE are not fully understood. Human volunteers ascended to high altitude (3860 m, 2 days), rats were exposed hypoxia in a hypobaric chamber (5000 days). was evaluated by Lake Louise Score (LLS), plasma corticotrophin-releasing hormone (CRH) cytokines TNF-α, IL-1β, IL-6 measured humans. Subsequently,...
Acute lung injury (ALI) is characterized by non-cardiogenic diffuse alveolar damage and often leads to a lethal consequence, particularly when hypoxia coexists. The treatment of ALI remains challenge: pulmonary inflammation both contribute its onset progression no effective prevention approach available. Here we aimed investigate the underlying mechanism interaction with in evaluate hypoxia-inducible factor 1α (HIF-1α) - crucial modulator as potential therapeutic target against ALI. First,...
Abstract Background Stromal interaction molecule 1 (STIM1) is a newly discovered Ca 2+ sensor on the endoplasmic reticulum which an indispensable part in activation of store-operated channels (SOC). Recent studies demonstrate that SOC pulmonary smooth muscle cells (PASMCs) were upregulated by chronic hypoxia contribute to enhanced vasoconstriction and vascular remodeling. However, exact role STIM1 development hypoxic hypertension(HPH) remains unclear. Methods In this study we investigated...
Chronic mountain sickness (CMS), originally characterized by excess hemoglobin (Hb), is currently diagnosed using score-based diagnostic criteria combined with excessive erythrocytosis and clinical symptoms. However, the current have limited applicability. We applied these to 1,029 Chinese Han males migrated been stayed at Qinghai-Tibet plateau (3,700–5,000 m) for 2–96 months investigate prevalence of CMS its correlations Hb concentration, altitude, length residence. Subjects were screened...
Acute mountain sickness (AMS), which may progress to life-threatening high altitude cerebral edema, is a major threat millions of people who live in or travel altitude. Although studies have revealed the risk factors and pathophysiology theories AMS, molecular mechanisms it do not comprehensively illustrate. Here, we used system-level methodology, RNA sequencing, explore AMS at genome-wide level 10 individuals. After exposure altitude, total 1,164 1,322 differentially expressed transcripts...
Establishment of an inflammatory milieu following elevated leukocyte adhesion to the vascular endothelium, which is mediated by transcriptional activation cell molecules (CAMs), contributes pathogenesis chronic hypoxia-induced pulmonary hypertension (HPH). The epigenetic switch that dictates CAM transactivation in response hypoxia endothelial cells leading up HPH not fully appreciated. We report here brahma-related gene 1 (Brg1) and brahma (Brm), two catalytic components mammalian chromatin...
Abstract The exposure of healthy subjects to high altitude represents a model explore the pathophysiology diseases related tissue hypoxia. We explored plasma metabolomics approach detect alterations induced by altitude. Plasma samples were collected from 60 both on plain and at (5300 m). Metabolite profiling was performed gas chromatography-mass spectrometry (GC-MS) ultra-performance liquid chromatography-quadrupole time-of-flight mass (UPLC-QTOFMS) in conjunction with univariate...
Background: Acute mountain sickness (AMS) is a common disabling condition in individuals experiencing high altitudes, which may progress to life-threatening altitude cerebral edema. Today, no established biomarkers are available for prediction the susceptibility of AMS. MicroRNAs emerge as promising sensitive and specific variety diseases. Thus, we sought identify circulating microRNAs suitable susceptible AMS before exposure altitude. Methods: We enrolled 109 healthy man adults collected...
The MTT assay, as a screening method, has been widely used to measure the viability and proliferation of cells. However, it should be noted that assay may not accurately reflect effect Cistanche tubulosa ethanolic extract on EA.hy926 cells viability. To investigate identity components responsible for contradictory observations echinacoside acteoside, two main phenylethanoid glycosides, from C. were isolated. data derived CCK-8, Hoechst 33342 annexin V-FITC/PI assays suggest caffeyl group...
Mitochondrial dysfunction plays a principal role in hypoxia-induced endothelial injury, which is involved hypoxic pulmonary hypertension and ischemic cardiovascular diseases. Recent studies have identified mitochondria-associated membranes (MAMs) that modulate mitochondrial function under variety of pathophysiological conditions such as high-fat diet-mediated insulin resistance, hypoxia reoxygenation-induced myocardial death, hypoxia-evoked vascular smooth muscle cell proliferation. However,...
Hypobaric hypoxia (HH) exposure can cause serious brain injury as well life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering development disease treatment. Here, we report cynomolgus monkeys (<i>Macaca</i> <i>fascicularis</i>) exposed acute HH developed human-like syndrome involving and abnormal behavior. Transcriptome profiling...
Acute mountain sickness (AMS) is a major health issue for people travelling to high altitudes. This study was designed comprehensively evaluate the changes in clinical characteristics and biochemical indices of high-altitude travelers determine whether these were associated with AMS.A total 14 52 determined 22 subjects before during acute exposure. Six hours after passive ascent 3648 m (Lhasa, China), Lake Louise Scoring (LLS) system 2018 used assess AMS, which defined as headache LLS...
Hypoxia induced pulmonary hypertension (HPH) represents a complex pathology that involves active vascular remodeling, loss of tone, enhanced inflammation, and increased deposition extracellular matrix proteins. Megakaryocytic leukemia 1 (MKL1) is transcriptional regulator known to influence cellular response stress signals in the vasculature. We report here chronic hypobaric hypoxia, MKL1 expression was up-regulated lungs rats. Short hairpin RNA (shRNA) mediated depletion significantly...
Altitude acclimatization is a physiological process that restores oxygen delivery to the tissues and promotes use under high altitude hypoxia. High sickness occurs in individuals without acclimatization. Unraveling molecular underpinnings of could help understand beneficial body responses hypoxia as well altered biological events un-acclimatized individuals. This study assessed adjustments circulating microRNA (cmiRNA) profiles exposed altitude, aiming explore humans.
Mitochondria-associated membranes (MAM) are a well-recognized contact link between the mitochondria and endoplasmic reticulum that affects mitochondrial biology vascular smooth muscle cells (VSMCs) proliferation via regulation of Ca2+(Ca2+m) influx. Nogo-B receptor (NgBR) plays vital role in proliferation, epithelial-mesenchymal transition, chemoresistance some tumors. Recent studies have revealed downregulation NgBR, which stimulates VSMCs, but underlying mechanism remains unclear. Here, we...
Background: The modulation of arachidonic acid (AA) metabolism pathway is identified in metabolic alterations after hypoxia exposure, but its biological function controversial. We aimed at integrating plasma metabolomic and transcriptomic approaches to systematically explore the roles AA response acute using an mountain sickness (AMS) model. Methods: Blood samples were obtained from 53 enrolled subjects before exposure high altitude. Ultra-performance liquid chromatography-quadrupole...
Background: Hypoxia appears in a number of extreme environments, including high altitudes, the deep sea, and during aviation, occurs cancer, cardiovascular disease, respiratory failures neurological disorders. Though it is well recognized that hypoxic preconditioning (HPC) exerts endogenous neuroprotective effect against severe hypoxia, mediators underlying molecular mechanism for protective are still not fully understood. This study established hippocampus metabolomics approach to explore...
As a typical model of hypoxia‑induced excessive erythrocytosis, high altitude polycythemia (HAPC) results in microcirculation disturbance, aggravates tissue hypoxia and severe clinical outcome, without any effective intervention methods except for returning to an oxygen‑rich environment. The present study aimed explore potential therapeutic targets which may participate the recovery HAPC by studying mechanisms reducing hemoglobin (HB) concentration during re‑oxygenation. A total 14 13...
Hypoxic preconditioning (HPC) is well‑known to exert a protective effect against hypoxic injury; however, the underlying molecular mechanism remains unclear. The present study utilized serum metabolomics approach detect alterations associated with HPC. In study, an animal model of HPC was established by exposing adult BALB/c mice acute repetitive hypoxia four times. samples were collected orbital blood sampling. Metabolite profiling performed using ultra‑performance liquid...
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