A5100688784- RNA modifications and cancer
- Extracellular vesicles in disease
- Metabolism and Genetic Disorders
- Immune cells in cancer
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Pelvic floor disorders treatments
- Cell Adhesion Molecules Research
- interferon and immune responses
- Signaling Pathways in Disease
- Pelvic and Acetabular Injuries
- Phagocytosis and Immune Regulation
- Coronary Interventions and Diagnostics
- Hernia repair and management
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Phytochemical Studies and Bioactivities
- NF-κB Signaling Pathways
- Mechanisms of cancer metastasis
- Alkaline Phosphatase Research Studies
- Hippo pathway signaling and YAP/TAZ
West China Medical Center of Sichuan University
2020-2025
Sichuan University
2022-2025
West China Hospital of Sichuan University
2025
Tibet Autonomous Region People's Hospital
2025
Third People's Hospital of Huzhou
2024
Huzhou University
2024
Beijing Children’s Hospital
2015-2023
Capital Medical University
2015-2023
Nanjing University of Chinese Medicine
2023
The University of Texas Southwestern Medical Center
2015-2022
Lipogenesis in liver is highest the postprandial state; insulin activates SREBP-1c, which transcriptionally genes involved FA synthesis, whereas glucose carbohydrate-responsive element-binding protein (ChREBP), both glycolysis and synthesis. Whether SREBP-1c ChREBP act independently of one another unknown. Here, we characterized mice with liver-specific deletion (L-Chrebp−/− mice). Hepatic deficiency resulted reduced mRNA levels glycolytic lipogenic enzymes, particularly response to sucrose...
Rationale: Atherosclerosis is characterized by lipid accumulation, plaque formation, and artery stenosis.The pharmacological treatment a promising therapy for atherosclerosis, but this approach faces major challenges such as targeted drug delivery, controlled release, non-specific clearance.Methods: Based on the finding that cathepsin k (CTSK) enzyme enriched in atherosclerotic lesions, we constructed an integrin αvβ3 CTSK-responsive nanoparticle to control release of rapamycin (RAP)...
Chronic inflammation, inflicted by the spillover of proinflammatory mediators, links metabolic dysfunction to nonalcoholic steatohepatitis (NASH). The epigenetic maneuverings that underscore accelerated synthesis mediators in response nutritional inputs are not clearly defined. Here we report ATP-dependent chromatin remodeling proteins Brahma-related gene 1 (Brg1) and Brahma (Brm) were up-regulated vitro cultured hepatocytes treated with free fatty acid or glucose vivo animal models NASH....
Rationale: Endothelial dysfunction inflicted by inflammation is found in a host of cardiovascular pathologies. One hallmark event this process the aggregation and adhesion leukocyte to vessel wall mediated upregulation molecules (CAM) endothelial cells at transcriptional level. The epigenetic modulator(s) CAM transactivation its underlying pathophysiological relevance remain poorly defined. Objective: Our goal was determine involvement Brahma related gene 1 (Brg1) (Brm) pathogenesis...
Chronic inflammation underscores the pathogenesis of a range human diseases. Lipopolysaccharide (LPS) elicits strong pro-inflammatory response in macrophages via transcription factor NF-κB. The epigenetic mechanism underlying LPS-induced is not completely appreciated. Herein we describe role for myocardin related A, or MRTF-A, this process. MRTF-A over-expression potentiated while silencing dampened NF-κB dependent transcription. deficiency also alleviated synthesis mediators mouse model...
Significance Famine kills millions of people each year. Survival requires the maintenance blood glucose. depletes body fat, thereby removing a source energy for hepatic glucose production. Here we used mouse model fat depletion to show that growth hormone (GH) maintains sugar by stimulating autophagy, process which liver digests its organelles provide and substrates producing When fat-depleted mice are fasted, their stomachs secrete ghrelin, GH secretagogue. The resultant elevation in...
Macrophage-dependent inflammatory response is considered a pivotal biological process that contributes to host of diseases when aberrantly activated. The underlying epigenetic mechanism not completely understood. We report here MKL1 was both sufficient and necessary for p65-dependent pro-inflammatory transcriptional program in immortalized macrophages, primary human mouse an animal model systemic inflammation (endotoxic shock). Extensive chromatin immunoprecipitation (ChIP) profiling...
Epithelial–mesenchymal transition (EMT) mediated by fluid shear stress (FSS) in the tumor microenvironment plays an important role driving metastasis of malignant tumor. As a mechanotransducer, Yes‐associated protein (YAP) is known to translocate into nucleus initiate transcription genes involved cell proliferation upon extracellular biophysical stimuli. Here, we showed that FSS facilitated cytoskeleton rearrangement hepatocellular carcinoma cells, which led release YAP from its binding...
Increased synthesis of endothelin-1 (ET-1) by human vascular endothelial cells (HVECs) in response to hypoxia underscores persistent vasoconstriction observed patients with pulmonary hypertension. The molecular mechanism whereby stimulates ET-1 gene transcription is not well understood. Here we report that megakaryocytic leukemia 1 (MKL1) potentiated hypoxia-induced transactivation HVECs. Disruption MKL1 activity either a dominant negative mutant or small interfering RNA mediated knockdown...
Enhanced interaction between vascular endothelial cells and circulating leukocytes, as a result of transcriptional activation cell adhesion molecules (CAM), helps establish proinflammatory milieu contributing to the pathogenesis chronic hypoxia-induced pulmonary hypertension. The molecular switch that dictates CAM transactivation is not clearly defined. Our goal was determine involvement modulator megakaryocytic leukemia 1 (MKL1), also known myocardin-related transcription factor A (MRTF-A),...
Establishment of an inflammatory milieu following elevated leukocyte adhesion to the vascular endothelium, which is mediated by transcriptional activation cell molecules (CAMs), contributes pathogenesis chronic hypoxia-induced pulmonary hypertension (HPH). The epigenetic switch that dictates CAM transactivation in response hypoxia endothelial cells leading up HPH not fully appreciated. We report here brahma-related gene 1 (Brg1) and brahma (Brm), two catalytic components mammalian chromatin...
Endothelin (ET-1) was initially identified as a potent vasoconstrictor contributing to the maintenance of vascular rhythm. Later studies have implicated ET-1, when aberrantly up-regulated within vasculature, in range human pathologies associated with disruption homeostasis. ET-1 has been shown invoke strong pro-inflammatory response smooth muscle cells (VSMCs); underlying mechanism, however, remains elusive. Here, we report that transcriptional modulator MRTF-A mediates activation mediators...
Background: Cancer-associated fibroblasts (CAFs) are of considerable importance in tumor progression by interacting with the microenvironment. However, hidden mechanism explaining how cells interact CAFs mechanical microenvironment remains largely unknown. Methods: We highlighted exosomes as mediator modulating interaction between liver cancer and under conditions. The normal hepatic stellate LX2 were exposed to medium or from HepG2 without fluid shear stress subjection, activation markers...