A5101498509- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photodynamic Therapy Research Studies
- Fibroblast Growth Factor Research
- Telomeres, Telomerase, and Senescence
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Quinazolinone synthesis and applications
- Histone Deacetylase Inhibitors Research
- Nanoparticle-Based Drug Delivery
- Phagocytosis and Immune Regulation
- Pharmacological Effects of Natural Compounds
- Liver physiology and pathology
- Nanocluster Synthesis and Applications
- Bone fractures and treatments
- Bioactive natural compounds
- Lymphoma Diagnosis and Treatment
- Silicon Nanostructures and Photoluminescence
- Respiratory Support and Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Periodontal Regeneration and Treatments
Wenzhou Medical University
2018-2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
Wenzhou University
2018-2021
Hangzhou Seventh Peoples Hospital
2021
Rutgers, The State University of New Jersey
2016-2021
North China University of Science and Technology
2021
Shenzhen Stock Exchange
2021
University of Chinese Academy of Sciences
2020
Xiamen Medical College
2019-2020
Xiamen University
2020
Indocyanine green (ICG) is a near-infrared (NIR) imaging agent and also an ideal light absorber for laser-mediated photothermal therapy. This NIR dye could serve as basis of dual-functional probe with integrated optical therapy capabilities. However, applications ICG remain limited by its concentration-dependent aggregation, poor aqueous stability, nonspecific binding to proteins lack target specificity. To overcome these limitations, novel ICG-containing nanostructure designed utilizing the...
Indocyanine green (ICG) is a conventional dye that can be used in clinical near-infrared (NIR) imaging, and it also an effective light absorber for laser-mediated photothermal therapy. However, applications of ICG were limited due to its fast degradation aqueous media quick clearance from the body. Herein, ICG-containing nanostructure, ICG-PL-PEG, was developed therapy, which self-assembled by phospholipid-polyethylene glycol (PL-PEG). Our vitro vivo experiments demonstrated ICG-PL-PEG...
Abstract The immunocheckpoint protein PD-1/PD-L1 is considered a promising target for cancer immunotherapeutics. However, the objective response rate using antibodies that block interaction between PD-1 and PD-L1 was less than 40%, mechanism underlying regulation of expression poorly understood. In this study, we identified miRNA let-7 posttranscriptionally suppresses expression. LIN28, an RNA binding upregulated in most cells, inhibits biogenesis let-7, thus promoting Therefore, inhibition...
Histone deacetylases (HDACs) mediate histone deacetylation, leading to transcriptional repression, which is involved in many diseases, including age-related tissue degeneration, heart failure and cancer.In this study, we were aimed investigate the expression, clinical significance biological function of HDAC4 esophageal carcinoma (EC).We found that mRNA protein are overexpressed squamous cell (ESCC) tissues lines.HDAC4 overexpression associated with higher tumor grade, advanced stage poor...
The objective of this work was to study the photoacoustic effect a special nanoparticle for selective cancer cell killing both in vitro and vivo.The nanoparticles (NPs) consisting indocyanine green (ICG), phospholipid-polyethylene glycol (PL-PEG) folic acid (FA) were used as cancer-targeting nanoprobes. Cancer cells incubated with ICG-PL-PEG-FA solution exposed laser pulses. Finally, tumors mice treated technique.High selectivity destruction observed. after treatment showed much slower...
hTERT, a catalytic component of human telomerase, is undetectable in normal somatic cells but up-regulated cancer and stem where telomere length maintained by telomerase. Accumulated evidence indicates that hTERT may have noncanonical functions beyond telomerase regulating the expression particular genes. However, comprehensive identification genes regulated unavailable. In this report, we expressed WT hTERTmut which displays dysfunctional activity, U2OS VA-13 immortalized fibroblast cells,...
Abstract TMPyP4 is widely considered as a potential photosensitizer in photodynamic therapy and G-quadruplex stabilizer for telomerase-based cancer therapeutics. However, its biological effects including possible adverse-effect are poorly understood. In this study, whole genome RNA-seq analysis was used to explore the alteration gene expression induced by TMPyP4. Unexpectedly, we find that 27.67% of changed genes were functionally related cell adhesion. Experimental evidences from adhesion...
Two types of Zn–Ln nanoclusters (Ln = Nd and Sm) were constructed using one long Schiff base ligand with a naphthyl backbone, the 12-metal Zn–Sm cluster shows interesting visible NIR luminescence sensing nitro explosives high sensitivity to 1,4-DNB TNT at ppb level.
Two new Pt(II) squares with quinoxaline-bridges selectively stabilize human telomeric G-quadruplexes high binding constants (107–109 M−1) and an unprecedented stoichiometric ratio of square/G-quadruplex (6 : 1). This selectivity is likely due to the squares' cube-like shape. Both also show significant telomerase inhibition anticancer efficacy.
Two cationic molecular rotors, 1 and 2, capable of real-time cell-cycle imaging by specifically dynamic monitoring nucleolus chromosome changes were developed. A further study shows that fluorescence enhancements in the are attributed to a combination effect interaction with nucleic acid high condensation chromosome.
Hepatic stellate cells (HSCs) are the important players in liver cirrhosis and cancer. They also act as critical mediators of immunosuppression hepatocellular carcinoma (HCC). In this study, we hypothesized that HSCs promote HCC progression via C3.C3 was knocked down using a shRNA retroviral plasmid. The conditioned medium from or shC3 (knockdown C3 by HSCs) collected to detect their effects on bone marrow (BM) T (including expansion apoptosis) vitro, an situ model mice.We found promoted...
Abstract Our recent study demonstrated that the QKI-5 regulated miRNA, miR-196b-5p , and it functions as an onco-microRNA in non-small cell lung cancer (NSCLC) by directly targeting GATA6 TSPAN12. However, role of NSCLC progression metastasis still remains unclear. We found promotes proliferation colony formation tumor suppressor, FAS. The expression FAS was significantly downregulated tissue samples negatively correlated with expression. Knocking down activates NFkB signaling subsequent IL6...
Although triple-negative breast cancer (TNBC) accounts for only 15% of cases, it is associated with a high relapse rate and poor outcome after standard treatment. Currently, the effective drugs treatment strategies TNBC remain limited, thus, developing treatments pressing. Several studies have demonstrated that both chalcone syringaldehyde anticancer effect, but their potential anti-TNBC bioactivity are still unknown.The present study aimed to synthesize chalcone-syringaldehyde hybrid (CSH1)...
Fibroblast growth factor receptors (FGFRs) play a critical role in the regulation of cancer cell proliferation, differentiation, and migration. However, development acquired resistance to FGFR inhibitors remains major challenge treating non-small lung (NSCLC), particularly due mutations at gatekeeper residue. In this study, we report discovery series irreversible targeting FGFR1–3, utilizing 2,4,5-trisubstituted pyrimidine scaffold. Through rational design, structure–activity relationship...
Acute lung injury (ALI) is a life-threatening inflammatory disease that lacks safe and effective treatment strategies. Harmine, an alkaloid derived from Peganum harmala L plants, exhibits anti-inflammatory activity. However, the protective effect of harmine against ALI its underlying mechanism remain unknown. This study aimed to elucidate therapeutic effects molecular mechanisms ALI. The were assessed in LPS-induced mice. Serum, bronchoalveolar lavage fluid (BALF), tissues routinely analyzed...
Two simple complexes [Pt(phen)(2)](PF(6))(2) and [Pt(bpy)(2)](PF(6))(2) exhibit high stabilization potential for G-quadruplex DNA with possessing higher capability due to its greater planarity.
The SWI/SNF chromatin remodeling complexes control accessibility of to transcriptional and coregulatory machineries. Chromatin plays important roles in normal physiology diseases, particularly cancer. ARID1A-containing complex is commonly mutated thought be a key tumor suppressor hepatocellular carcinoma (HCC), but its regulation response oncogenic signals remains poorly understood. mTOR conserved central controller cell growth an driver HCC. Remarkably, cancer mutations are mutually...
Herein, two photosensitive platinum(II)-based tripods were designed and synthesized. Notably, complex 1 ({[Pt(dien)]3 L}(NO3 )6 , L=tri(4-pyridylphenyl)amine dien=diethylenetriamine), which mainly accumulated in the cell nucleus, exhibited very low cytotoxicity absence of light irradiation, but displayed a remarkable increase upon visible irradiation. Mechanistic investigations revealed that tripod interacted with DNA induced ROS generation consequently elicited rapid damage response;...
Two porphyrin-bridged tetranuclear platinum(II) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability targeting G-quadruplexes rather than double-stranded structure. excellent anticancer activity is result a dual effect, inhibition telomerase and repression oncogene expression.