A5001447073- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Photoacoustic and Ultrasonic Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Laser Applications in Dentistry and Medicine
- Olfactory and Sensory Function Studies
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Biochemical Analysis and Sensing Techniques
- Nanoparticle-Based Drug Delivery
- Neurobiology and Insect Physiology Research
- Advanced Fluorescence Microscopy Techniques
- Infrared Thermography in Medicine
- Optical Coherence Tomography Applications
- Ultrasound and Hyperthermia Applications
- Spaceflight effects on biology
- Digital Radiography and Breast Imaging
- Cancer, Stress, Anesthesia, and Immune Response
- Photoreceptor and optogenetics research
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Advanced X-ray Imaging Techniques
University of Oklahoma
2000-2024
University of Oklahoma Health Sciences Center
2022-2024
University of Central Oklahoma
2012-2023
Huazhong University of Science and Technology
2013-2020
Wuhan National Laboratory for Optoelectronics
2013-2020
Norman Regional Hospital
2020
Cheshire Medical Center
2020
Oklahoma Library Association
2018-2019
Shanghai Skin Disease Hospital
2015-2018
Tongji University
2016-2018
Single-walled carbon nanotubes (SWNTs) have a high optical absorbance in the near-infrared (NIR) region. In this special window, biological systems are known to be highly transparent. The properties of SWNTs provide an opportunity for selective photothermal therapy cancer treatment. Specifically, CoMoCAT® with uniform size (about 0.81 nm) and narrow absorption peak at 980 nm ideal candidates such novel approach. Here, conjugated folate, which can bind specifically surface folate receptor...
Indocyanine green (ICG) is a near-infrared (NIR) imaging agent and also an ideal light absorber for laser-mediated photothermal therapy. This NIR dye could serve as basis of dual-functional probe with integrated optical therapy capabilities. However, applications ICG remain limited by its concentration-dependent aggregation, poor aqueous stability, nonspecific binding to proteins lack target specificity. To overcome these limitations, novel ICG-containing nanostructure designed utilizing the...
Combined phototherapy and immunotherapy demonstrates strong potential in the treatment of metastatic cancers. An upconversion nanoparticle (UCNP) based antigen-capturing nanoplatform is designed to synergize phototherapies immunotherapy. In particular, this constructed via self-assembly DSPE-PEG-maleimide indocyanine green (ICG) onto UCNPs, followed by loading photosensitizer rose bengal (RB). ICG significantly enhances RB-based photodynamic therapy efficiency UCNP/ICG/RB-mal upon activation...
Indocyanine green (ICG) is a conventional dye that can be used in clinical near-infrared (NIR) imaging, and it also an effective light absorber for laser-mediated photothermal therapy. However, applications of ICG were limited due to its fast degradation aqueous media quick clearance from the body. Herein, ICG-containing nanostructure, ICG-PL-PEG, was developed therapy, which self-assembled by phospholipid-polyethylene glycol (PL-PEG). Our vitro vivo experiments demonstrated ICG-PL-PEG...
The site of impulse initiation is crucial for the integrative actions mammalian central neurons, but this question currently controversial. Some recent studies support classical evidence that always arises in soma-axon hillock region, with back-propagation through excitable dendrites, whereas others indicate dendrites are sufficiently to initiate impulses propagate forward along dendrite hillock. This issue has been addressed olfactory mitral cell, which excitatory synaptic input restricted...
In the past decade, much has been elucidated regarding functional organization of axonal connection olfactory sensory neurons to bulb (OB) glomeruli. However, manner in which projection OB process odorant input and send this information higher brain centers remains unclear. Here, we report long-range, large-scale tracing patterns using two-photon microscopy. Tracer injection into a single glomerulus demonstrated widely distributed mitral/tufted cell projections on lateroventral surface mouse...
Olfactory sensory neurons converge onto glomeruli in the olfactory bulb (OB) to form modular information processing units. Similar input modules are organized translaminar columns for other modalities. It has been less clear OB whether initial organization relates a columnar structure deeper layers involved local circuit processing. To probe synaptic connectivity OB, we injected retrograde-specific strain of pseudorabies virus into rat and piriform cortex. The viral-staining patterns...
Abstract Nanomaterials have recently attracted much attention as efficient transducers for cancer photothermal therapy, based on their intrinsic absorption properties in the near‐infrared region. This study explores a novel therapy model with mitochondria‐targeting single‐walled carbon nanotubes (SWNTs), which act efficiently to convert 980‐nm laser energy into heat and selectively destroy target mitochondria, thereby inducing mitochondrial depolarization, cytochrome c release, caspase 3...
Translocation and localization of single-walled carbon nanotubes (SWNTs) in normal cancerous cells have significant biomedical implications. In this study, SWNTs functionalized with different biomolecules were observed confocal laser scanning microscopy. Functionalized PL-PEG, found to localize exclusively mitochondria both tumor due mitochondrial transmembrane potential, but they mainly lysosomes macrophages phagocytosis. However, when conjugated molecules, the subcellular surface-modified...
BSA-bioinspired, immunoadjuvant-loaded gold nanorods for synergetic cancer photothermal therapy and immunotherapy.
Phototherapy, particularly photothermal therapy (PTT) and photodynamic (PDT), has become a promising therapeutic technique for the treatment of skin cancers because its minial invasiveness, high efficacy, low side effects. Nevertheless, single modality therapy, either PTT or PDT, limited clinical effectiveness in treating cancers. Thus, combined applications PDT have been frequently reported; however, often require their respective photoagents excitation light sources, resulting challenges...
Abstract Purpose: To develop a synergistic combination therapy for advanced pancreatic cancer, using local phototherapy and immunotherapy, to determine the efficacy mechanism of novel highly metastatic tumor model in mice. Experimental Design: Mice bearing Panc02-H7 tumors (both subcutaneous orthotopic) were treated with noninvasive or interventional photothermal therapy, followed by application an immunoadjuvant. Tumor growth animal survival assessed. Immune cell populations within spleen...
Photoimmunotherapy has attracted much attention recently for the treatment of metastatic tumors. The development smart nanocomposites imaging-guided therapies is needed to improve efficacy cancer treatment. Herein, a PEGylated nanocomposite was developed photothermal-immunotherapy. In particular, this formulated by hybridizing Fe3O4 nanoparticles (FNPs) with reduced-graphene oxide (rGO) through electrostatic interaction, modified PEG-NH2 on surface FNPs/rGO. FNPs/rGO-PEG are excellent agents...