Combined phototherapy and immunotherapy demonstrates strong potential in the treatment of metastatic cancers. An upconversion nanoparticle (UCNP) based antigen-capturing nanoplatform is designed to synergize phototherapies immunotherapy. In particular, this constructed via self-assembly DSPE-PEG-maleimide indocyanine green (ICG) onto UCNPs, followed by loading photosensitizer rose bengal (RB). ICG significantly enhances RB-based photodynamic therapy efficiency UCNP/ICG/RB-mal upon activation...

BSA-bioinspired, immunoadjuvant-loaded gold nanorods for synergetic cancer photothermal therapy and immunotherapy.

As a highly stable band gap semiconductor, antimonene is an intriguing two-dimensional (2D) material in optoelectronics. However, its short layer distance and strong binding energy make it challenging to prepare high-quality large 2D antimonene; therefore, predicted tunable has not been experimentally confirmed. Now, approach smooth with uniform layers that uses pregrinding subsequent sonication-assisted liquid-phase exfoliation process established. Mortar provides shear force along the...

The synthesis and characterization of gold nanoparticles (AuNPs) entrapped within polyethylene glycol (PEG)-modified polyethylenimine (PEI) for blood pool tumor computed tomography (CT) imaging are reported. In this approach, partially PEGylated PEI was used as a template AuNP synthesis, followed by acetylating the remaining surface amines. synthesized PEI-entrapped AuNPs (Au PENPs) were characterized via different methods. Our results reveal that Au PENPs can be tuned to have an core size...

Exploitation of novel hybrid nanomaterials for combinational tumor therapy is challenging. In this work, we synthesized dendrimer-modified MoS2 nanoflakes gene silencing and photothermal (PTT) cancer cells. Hydrothermally were modified with generation 5 (G5) poly(amidoamine) dendrimers partially functionalized lipoic acid via disulfide bond. The formed G5-MoS2 display good colloidal stability superior conversion efficiency stability. With the dendrimer surface amines on their surface, are...

Photoimmunotherapy has attracted much attention recently for the treatment of metastatic tumors. The development smart nanocomposites imaging-guided therapies is needed to improve efficacy cancer treatment. Herein, a PEGylated nanocomposite was developed photothermal-immunotherapy. In particular, this formulated by hybridizing Fe3O4 nanoparticles (FNPs) with reduced-graphene oxide (rGO) through electrostatic interaction, modified PEG-NH2 on surface FNPs/rGO. FNPs/rGO-PEG are excellent agents...

The development of multifunctional nanoprobes with a targeting capability for efficient molecular imaging tumors still remains great challenge. Herein, we report the synthesis and characterization folic acid (FA)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) via facile polyethylene glycol (PEG) linking strategy in vivo targeted tumor computed tomography (CT) applications. In this study, amine-terminated poly(amidoamine) dendrimers generation 5 (G5.NH2) sequentially modified by...

We report the facile synthesis of polyaniline (PANI)-loaded γ-polyglutamic acid (γ-PGA) nanogels (NGs) for photoacoustic (PA) imaging-guided photothermal therapy (PTT) tumors. In this work, γ-PGA NGs were first formed via a double emulsion approach, followed by crosslinking with cystamine dihydrochloride (Cys) 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride coupling chemistry. The γ-PGA/Cys employed as nanoreactor to load aniline monomers an electrostatic interaction subsequent...

We report here a general approach to synthesizing dendrimer-stabilized bismuth sulfide nanoparticles (Bi2S3 DSNPs) for potential computed tomography (CT) imaging applications. In this study, ethylenediamine core glycidol hydroxyl-terminated generation 4 poly(amidoamine) dendrimers (G4.NGlyOH) were used as stabilizers first complex the Bi(III) ions, followed by reaction with hydrogen generate Bi2S3 DSNPs. By varying molar ratio of Bi atom dendrimer, stable DSNPs an average size range 5.2–5.7...

Antifouling manganese oxide (Mn3O4) nanoparticles (NPs) were synthesized by solvothermal decomposition of tris(2,4-pentanedionato) manganese(III) in the presence trisodium citrate, followed surface modification with polyethylene glycol and l-cysteine. The as-prepared have a uniform size distribution, good colloidal stability cytocompatibility. l-cysteine rendered particles much longer blood circulation time (half-decay 28.4 h) than those without (18.5 h), decreased macrophage cellular...

Abstract As a highly stable band gap semiconductor, antimonene is an intriguing two‐dimensional (2D) material in optoelectronics. However, its short layer distance and strong binding energy make it challenging to prepare high‐quality large 2D antimonene; therefore, predicted tunable has not been experimentally confirmed. Now, approach smooth with uniform layers that uses pregrinding subsequent sonication‐assisted liquid‐phase exfoliation process established. Mortar provides shear force along...

The development of cost-effective targeted drug delivery systems for cancer chemotherapy still remains a great challenging task. Here, we describe the synthesis and characterization multifunctional polyethylenimine (PEI) as an effective vehicle to load anticancer doxorubicin (DOX) in vivo therapy. In this study, PEI was sequentially conjugated with polyethylene glycol (PEG) monomethyl ether, PEGylated folic acid (FA), fluorescein isothiocyanate (FI). This followed by acetylation remaining...

Radiotherapy is an indispensable modality in comprehensive treatment of breast cancer. However, inherent or acquired radiation resistance tumors compromises the efficacy radiotherapy. Herein, we found that CD146, a unique epithelial-to-mesenchymal transition (EMT) inducer particularly highly expressed triple-negative cancer (TNBC), dramatically induced by ionizing irradiation. Further study demonstrates CD146 promotes tumor cell radioresistance vitro and vivo. Specifically, report underlying...

To synthesize and characterize cost-efficient polyethylenimine-entrapped gold nanoparticles loaded with gadolinium (Gd@Au PENPs) for dual-mode computed tomography (CT)/magnetic resonance (MR) imaging applications.PEGylated PEI modified (Gd) chelator (DOTA) was used as a template to the Gd@Au PENPs particles were well characterized in terms of their physicochemical properties, cytotoxicity performances CT MR vitro vivo.The formed low can be highly efficient contrast agent CT/MR blood pool...

We report the construction and characterization of polyethylenimine (PEI)-entrapped gold nanoparticles (AuNPs) chelated with gadolinium (Gd) ions for targeted dual mode tumor CT/MR imaging in vivo. In this work, polyethylene glycol (PEG) monomethyl ether-modified PEI was sequentially modified Gd chelator folic acid (FA)-linked PEG (FA-PEG) used as a template to synthesize AuNPs, followed by Gd(III) chelation acetylation remaining surface amines. The formed FA-targeted PEI-entrapped AuNPs...

We report the construction and characterization of 99mTc-labeled arginine-glycine-aspartic acid (RGD)-polyethylenimine (PEI) conjugates with entrapped gold nanoparticles in cavities (RGD-99mTc-Au PENPs) for dual-mode single-photon emission computed tomography (SPECT)/computed (CT) imaging an orthotopic hepatic carcinoma model. In this study, PEI was successively decorated diethylenetriaminepentaacetic acid, poly(ethylene glycol) (PEG), PEGylated RGD segments, utilized as effective...

We report a facile approach to form iron oxide nanoparticle (NP)-loaded γ-polyglutamic acid (γ-PGA) nanogels (NGs) for MR imaging of tumors. In this study, γ-PGA with carboxyl groups activated by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) in aqueous solution was firstly emulsified, followed situ chemical crosslinking polyethyleneimine (PEI)-coated NPs (PEI-Fe3O4 NPs) core size 8.9 ± 2.1 nm synthesized via mild reduction route. The formed NGs containing (γ-PGA/PEI-Fe3O4...