A5113832137- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Diagnosis and Treatment of Venous Diseases
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Central Venous Catheters and Hemodialysis
- Advanced Nanomaterials in Catalysis
- Infectious Aortic and Vascular Conditions
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Cardiac, Anesthesia and Surgical Outcomes
- Nerve injury and regeneration
- Angiogenesis and VEGF in Cancer
- Photoacoustic and Ultrasonic Imaging
- Tissue Engineering and Regenerative Medicine
- Dendrimers and Hyperbranched Polymers
- Atherosclerosis and Cardiovascular Diseases
- Abdominal vascular conditions and treatments
- Quantum Dots Synthesis And Properties
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Wenzhou Medical University
2023-2024
Indiana University School of Medicine
2019
Shenzhen Technology University
2018
State Council of the People's Republic of China
2017
Shanghai Second People's Hospital
2006
Chinese Academy of Medical Sciences & Peking Union Medical College
2001
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2001
Institute of Laboratory Animal Science
2001
Critical limb ischemia, the final course of peripheral artery disease, is characterized by an insufficient supply blood flow and excessive oxidative stress. H2 S molecular therapy possesses huge potential for accelerating revascularization scavenging intracellular reactive oxygen species (ROS). Moreover, it found that BMP6 most significantly up-expressed secreted protein-related gene in HUVECs treated with GYY4137, a donor, based on transcriptome analysis. Herein, UIO-66-NH2 @GYY4137@BMP6...
A new generation of photothermal theranostic agents is developed based on Cu3BiS3 nanocrystals. computed tomography imaging response and effect, as well near-infrared fluorescence emission, can be simultaneously achieved through nanocrystals rather than frequently used nanocomposites. These results provide some insight into the synergistic effect from bimetal sulphide semiconductor compounds for theragnosis therapy.
This study shows that Au nanorods are a promising theranostic platform for the diagnosis and photothermal therapy of inflammation associated diseases.
Copper‐based ternary bimetal chalcogenides have very promising potential as multifunctional theragnosis nanoplatform for photothermal treatment of tumors. However, the design and synthesis such an effective platform remains challenging. In this study, hydrophilic CuCo 2 S 4 nanocrystals (NCs) with a desirable size ≈10 nm are synthesized by simple one‐pot hydrothermal route. The as‐prepared ultrasmall NCs show: 1) intense near‐infrared absorption, which is attributed to 3d electronic...
Reconstruction of the aortic major branches during thoracic endovascular repair is complicated because complex anatomic configuration and variation arch. In situ laser fenestration has shown great potential for revascularization branches. This study aims to evaluate feasibility, effectiveness, safety in on three arch repair.Before clinical application, polytetrafluoroethylene Dacron grafts were fenestrated by an 810-nm system ex vivo, which did not damage bare metal portion endografts...
With the increasing demand for wearable and implantable electronics, structured sensors with exceptional performance in sensitivity, stretchability, biocompatibility, adhesion to biological surfaces have become essential.
The gold standard treatment for peripheral nerve injuries (PNIs) is the autologous graft, while it associated with shortage of donors and results in major complications. In present study, we engineer a graphene mesh-supported double-network (DN) hydrogel scaffold, loaded netrin-1. Natural alginate gelatin-methacryloyl entangled that synthesized via fast exchange ions ultraviolet irradiation provide proper mechanical strength excellent biocompatibility can also serve as reservoir Meanwhile,...
Abstract Background Diabetic limb ischemia is a clinical syndrome and refractory to therapy. Our previous study demonstrated that adipose-derived stem cells (ADSCs) overexpressing glyoxalase-1 (GLO-1) promoted the regeneration of ischemic lower limbs in diabetic mice, but low survival rate, difficulty differentiation, tumorigenicity transplanted restricted its application. Recent studies have found exosomes secreted by ADSCs advantages containing parental beneficial factors exhibiting...
Preclinical studies have suggested that adipose-derived mesenchymal stem cells (ADSCs) transplantation can suppress abdominal aortic inflammation and aneurysm expansion through paracrine factors. Yet, the mechanism of action is not fully understood. In present study, we further examined function ADSC-derived exosomes (ADSC-exos) their microRNA-17-5p (miR-17-5p) on (AAA) progression.ADSC-exos were isolated identified. DiR PKH67 staining used to trace ADSC-exo in vivo vitro. Raw264.7 applied...
The development of multifunctional nanoprobes with a targeting capability for efficient molecular imaging tumors still remains great challenge. Herein, we report the synthesis and characterization folic acid (FA)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) via facile polyethylene glycol (PEG) linking strategy in vivo targeted tumor computed tomography (CT) applications. In this study, amine-terminated poly(amidoamine) dendrimers generation 5 (G5.NH2) sequentially modified by...
The PVP coated Fe<sub>3</sub>S<sub>4</sub> tetragonal nanosheets could be employed to realize magnetic resonance imaging guided photothermal/chemodynamic therapy and body-clearance without appreciable toxic side effects.
Abstract Diabetic patients suffer from peripheral nerve injury with slow and incomplete regeneration owing to hyperglycemia microvascular complications. This study develops a graphene‐based guidance conduit by incorporating natural double network hydrogel neurotrophic concentration gradient non‐invasive treatment for diabetics. GelMA/silk fibroin plays quadruple roles rapid setting/curing, suitable mechanical supporting, good biocompatibility, sustainable growth factor delivery. Meanwhile,...
Abstract Abdominal aortic aneurysm (AAA) is a common and potentially life‐threatening condition. Chronic inflammation closely associated with the pathogenesis of AAA. Nerve injury‐induced protein 1 (NINJ1) increasingly acknowledged as significant regulator inflammatory process. However, precise involvement NINJ1 in AAA formation remains largely unexplored. The present study finds that expression level elevated, along specific macrophages within human angiotensin II (Ang II)‐induced murine...
Abstract Background Vascular calcification (VC) is a complication in diabetes mellitus (DM) patients. Osteogenic phenotype switching of vascular smooth muscle cells (VSMCs) plays critical role diabetes-related VC. Mitophagy can inhibit VSMCs. This study aimed to investigate the glucagon-like peptide-1 receptor (GLP-1R) agonist exendin 4 (EX4) mitophagy-induced switching. Materials and methods The status VC T2DM mice was monitored using Von Kossa Alizarin Red S (ARS) staining mouse aortic...
We report here a general approach to synthesizing dendrimer-stabilized bismuth sulfide nanoparticles (Bi2S3 DSNPs) for potential computed tomography (CT) imaging applications. In this study, ethylenediamine core glycidol hydroxyl-terminated generation 4 poly(amidoamine) dendrimers (G4.NGlyOH) were used as stabilizers first complex the Bi(III) ions, followed by reaction with hydrogen generate Bi2S3 DSNPs. By varying molar ratio of Bi atom dendrimer, stable DSNPs an average size range 5.2–5.7...
Changing the phases and morphologies of MoO<sub>3−x</sub> nanomaterials, obtained MoO<sub>2</sub> nanoclusters can be used in efficient cancer theragnosis therapy.
Abstract Adipose-derived stem cell (ADSC)-based therapy is promising for critical limb ischemia (CLI) treatment, especially in patients with diabetes. However, the therapeutic effects of diabetic ADSCs (D-ADSCs) are impaired by diabetes, possibly through intracellular reactive oxygen species (ROS) accumulation. The objective present study was to detect whether overexpression methylglyoxal-metabolizing enzyme glyoxalase-1 (GLO1), which reduces ROS D-ADSCs, can restore their proangiogenic...
Previous research has reported that the gut microbiota performs an essential role in sleep through microbiome-gut-brain axis. However, causal association between and remains undetermined.We performed a two-sample, bidirectional Mendelian randomization (MR) analysis using genome-wide study summary data of self-reported traits from MiBioGen consortium UK Biobank to investigate relationships 119 bacterial genera seven sleep-associated traits. We calculated effect estimates by inverse-variance...
Iliac Vein Compression Syndrome (IVCS) is a common risk factor for deep vein thrombosis in the lower extremities. The objective of this study was to investigate whether employing porous medium model simulate compressed region an iliac could improve reliability and accuracy Computational Fluid Dynamics (CFD) analysis outcomes IVCS. Pre-operative Computed Tomography (CT) scan images patients with IVCS were utilized reconstruct models illustrating both compression collateral circulation vein. A...
Objectives Aortic dissection (AD) is a life-threatening condition that requires intensive care and management. This paper explores the role of fluid management in clinical AD patients, which has been unclear despite substantial existing research conducted on treatment AD. Design A retrospective case-control study using data for patients from public databases. Setting Two unit (ICU) databases with hospital courses USA, Medical Information Mart Intensive Care (MIMIC)-IV critical dataset eICU...
Objective: This study aimed to prospectively evaluate the safety and efficacy of left subclavian artery (LSA) revascularization via in-situ laser-assisted fenestration during thoracic endovascular aortic repair (TEVAR) for type B dissection (TBAD). Methods: was a prospective, single-arm, multicenter that enrolled patients with complicated or high-risk acute TBAD. The primary endpoint freedom from composite major adverse events (mortality, stroke, myocardial infarction, paraplegia, Ia...