A5044961641- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Fungal Biology and Applications
- Wireless Communication Security Techniques
- Cooperative Communication and Network Coding
- Cellular transport and secretion
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Mesenchymal stem cell research
- Insect and Arachnid Ecology and Behavior
- Retinal Development and Disorders
- Sleep and Wakefulness Research
- Enzyme Structure and Function
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Phytochemistry and Bioactivity Studies
- Cellular Automata and Applications
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Microbial Metabolism and Applications
- Synthesis and Biological Evaluation
- DNA and Biological Computing
Freie Universität Berlin
2018-2025
East China University of Technology
2023-2025
Charité - Universitätsmedizin Berlin
2020-2025
Ruijin Hospital
2024
Shanghai Institute of Hematology
2024
State Key Laboratory of Medical Genomics
2024
Shanghai Jiao Tong University
2016-2023
Nanjing University of Chinese Medicine
2021-2023
Shanghai Ninth People's Hospital
2023
Fujian Medical University
2019-2022
Abstract Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic plasticity homeostatically maintains functionality during perturbations and enables memory formation. Postsynaptic targets receptors, but mechanisms regulating the apparatus remain largely enigmatic. By studying Drosophila neuromuscular junctions (NMJs) we show that AZs consist of nano-modular sites identify a...
Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline neurodegeneration. Supplementing levels of spermidine, body-endogenous metabolite, has been shown promote mitochondrial respiration delay aspects aging. Spermidine serves as the amino-butyl group donor for synthesis hypusine (Nε-[4-amino-2-hydroxybutyl]-lysine) at specific lysine residue eukaryotic translation initiation factor 5A (eIF5A). Here, we show that Drosophila...
Slow-wave rhythms characteristic of deep sleep oscillate in the delta band (0.5–4 Hz) and can be found across various brain regions vertebrates. Across phyla, however, an understanding mechanisms underlying oscillations how these link to behavior remains limited. Here, we discover compound sleep-regulating R5 network Drosophila. We find that power slow-wave increases with need is subject diurnal variation. Optical multi-unit voltage recordings reveal single neurons get synchronized by...
Sleep is universal across species and essential for quality of life health, as evidenced by the consequences sleep loss. might homeostatically normalize synaptic gains made over wake states in order to reset information processing storage support learning, sleep-associated (ultra)structural changes have been demonstrated recently. However, causal relationships between molecular status synapses, homeostatic regulation, learning processes yet be established. We show here that presynaptic...
The search for highly selective sensitizers with a novel mechanism tumor targeting therapy is of considerable interest. In this work, we have developed series new biotin-targeted Au(I) complexes. Through systematic biological evaluation and comparison, biotinylated complex 3a containing triphenylphosphine ligand was screened, as it realized both prominent efficient inhibition cytotoxicity to cancer cells, the effect better than that popularly used auranofin. Meanwhile, 3a, potent...
Multidrug-resistant (MDR) Gram-negative bacteria have become a global threat to human life and health, novel antibiotics are urgently needed. The thioredoxin (Trx) system can be used as an antibacterial target combat MDR bacteria. Here, we found that two active gold(I) selenium N-heterocyclic carbene complexes H7 H8 show more promising effects against than auranofin. Both irreversibly inhibit the bacterial TrxR activity via targeting redox-active motif, abolishing capacity of quench reactive...
Six new prenylated hydroquinones of ganocalidin A–F (<bold>1–6</bold>) and two compounds ganocalicine A (<bold>7</bold>) B (<bold>8</bold>), together with sixteen known (<bold>9–24</bold>) were isolated from an extract the fruiting body <italic>Ganoderma calidophilum</italic>.
A novel photocatalytic method for the synthesis of 1,4-benzoxazepine using 2-alkoxyarylaldehyde as an oxygen source and N-arylglycine a nitrogen has been reported. This is mild, efficient, fast, corresponding reaction can be completed within 2 h at room temperature under atmosphere light-irradiation conditions. Mechanistic studies have confirmed that this scheme involves decarboxylation cyclization provides convenient pathway preparation various 2-alkyl-N-phenyl-substituted 1,4-benzoxazepine.
Sleep is crucial for cognitive functions and life span across species. While sleep homeostasis processes are linked through cellular synaptic plasticity, the signaling pathways connecting them remain unclear. Here, we show that Drosophila insomniac ( inc ) short mutants, which lack an adaptor protein autism-associated Cullin-3 ubiquitin ligase, exhibited enhanced Pavlovian aversive olfactory learning memory, unlike other mutants with normal or reduced memory. Through a genetic modifier...
Ganoderma lucidum (Leyss. ex Fr.) Karst. (G. lucidum, GL) belongs to the family of Ganodermataceae (Basidiomycetes), and possesses activities including antitumor, antimicrobial, antiviral, antiaging activities. Triterpenoids are typical chemical constituents in G. play an important role anti-cancer effects. According substituent group at carbon 26 position, GL total triterpenes fraction can be divided into two types, Neutral Triterpene Fraction (NTF) Acidic (ATF). The effects acidic...
Perturbations to postsynaptic glutamate receptors (GluRs) trigger retrograde signaling precisely increase presynaptic neurotransmitter release, maintaining stable levels of synaptic strength, a process referred as homeostatic regulation. However, the structural change regulation remains poorly defined. At wild-type Drosophila neuromuscular junction synapse, there is one Bruchpilot (Brp) ring detected by superresolution microscopy at active zones (AZs). In present study, we report multiple...
Amylose content (AC), which is regulated by the Waxy (Wx) gene, a major indicator of eating and cooking quality (ECQ) in rice (Oryza sativa). Thus far, only limited number mutations N-terminal domain Wx were found to have impact on AC grains no with such effects reported for other regions protein. Here, nucleotide substitutions middle region generated adenine cytosine base editors. The led changes 15 amino acid residues Wx, series novel alleles ACs 0.3%-29.43% (wild type 19.87%) obtained....
Fatty acid metabolism plays an important role in brain development and function. Mutations acyl-CoA synthetase long-chain family member 4 (ACSL4), which converts fatty acids to acyl-CoAs, result nonsyndromic X-linked mental retardation. ACSL4 is highly expressed the hippocampus, a structure critical for learning memory. However, underlying mechanism by mutations of lead retardation remains poorly understood. We report here that dAcsl, Drosophila ortholog ACSL3, inhibits synaptic growth...
The synthesis of quinazolinones via a visible light-mediated reaction benzyl bromides with 2-aminobenzamides is reported, and the HBr generated during first step promoted subsequent step.
ABSTRACT Nervous system development and function are tightly regulated by metabolic processes, including the metabolism of lipids such as fatty acids. Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) associated with non-syndromic intellectual disabilities. We previously reported that Acsl, Drosophila ortholog mammalian ACSL3 ACSL4, inhibits neuromuscular synapse growth suppressing bone morphogenetic protein (BMP) signaling. Here, we report Acsl regulates composition acids membrane...
Lipids are structural components of cellular membranes and signaling molecules that widely involved in development diseases, but the underlying molecular mechanisms poorly understood, partly because vast variety lipid species complexity synthetic turnover pathways. From a genetic screen, we identify mannosyl glucosylceramide (MacCer), glycosphingolipid (GSL), promotes synaptic bouton formation at Drosophila neuromuscular junction (NMJ). Pharmacological analysis shows NMJ growth-promoting...
Mast cells (MCs) are known to participate in a variety of patho-physiological processes depending largely on the intragranular mediators and production cytokines chemokines during degranulation. Recently, extracellular vesicles (EVs) have been implicated important functions for MCs, but components MC-derived EVs not yet well-characterized. In this study, we aimed identify signatures proteins, long non-coding RNAs (lncRNAs), microRNAs (miRNAs) derived from resting (Rest-EV) degranulated...