A5046730690- Metabolomics and Mass Spectrometry Studies
- Physiological and biochemical adaptations
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- RNA modifications and cancer
- Effects and risks of endocrine disrupting chemicals
- Heavy Metal Exposure and Toxicity
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Diet and metabolism studies
- Click Chemistry and Applications
- Air Quality and Health Impacts
- Ferroptosis and cancer prognosis
- Skin Protection and Aging
- Trace Elements in Health
- Metal complexes synthesis and properties
- Aquaculture Nutrition and Growth
- Biotin and Related Studies
- Aluminum toxicity and tolerance in plants and animals
- Antimicrobial Peptides and Activities
- GDF15 and Related Biomarkers
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
Harvard University
2024-2025
Guangdong Ocean University
2022-2024
Nanjing University of Chinese Medicine
2020-2023
Beijing Normal University - Hong Kong Baptist University United International College
2020-2023
Beijing Normal University
2020-2023
Hong Kong Baptist University
2010-2023
Southern Medical University
2023
Shenzhen Center for Disease Control and Prevention
2020
South China University of Technology
2018-2019
Infinitus (China)
2019
Emerging research supports that triclosan (TCS), an antimicrobial agent found in thousands of consumer products, exacerbates colitis and colitis-associated colorectal tumorigenesis animal models. While the intestinal toxicities TCS require presence gut microbiota, molecular mechanisms involved have not been defined. Here we show commensal microbes mediate metabolic activation colon drive its toxicology. Using a range vitro, ex vivo, vivo approaches, identify specific microbial...
The search for highly selective sensitizers with a novel mechanism tumor targeting therapy is of considerable interest. In this work, we have developed series new biotin-targeted Au(I) complexes. Through systematic biological evaluation and comparison, biotinylated complex 3a containing triphenylphosphine ligand was screened, as it realized both prominent efficient inhibition cytotoxicity to cancer cells, the effect better than that popularly used auranofin. Meanwhile, 3a, potent...
Multidrug-resistant (MDR) Gram-negative bacteria have become a global threat to human life and health, novel antibiotics are urgently needed. The thioredoxin (Trx) system can be used as an antibacterial target combat MDR bacteria. Here, we found that two active gold(I) selenium N-heterocyclic carbene complexes H7 H8 show more promising effects against than auranofin. Both irreversibly inhibit the bacterial TrxR activity via targeting redox-active motif, abolishing capacity of quench reactive...
Cadmium is a well-known hazardous pollutant that mainly comes from dietary, tobacco and occupational exposure, posing threat to kidney. However, there still lack of systematic study on metabolic pathways urinary biomarkers related its nephrotoxicity under cadmium exposure for both females males. In this study, mass spectrometry-based metabolomics investigation cohort 144 volunteers was conducted explore sex-specific alteration screen cadmium-induced nephrotoxicity. When the concentration...
Abstract Trillions of viruses inhabit the gastrointestinal tract. Some them have been well-studied on their roles in infection and human health, but majority remains unsurveyed. It has established that composition gut virome is highly variable based changes diet, physical state, environmental factors. However, effect host genetic factors, for example ethnic origin, rarely investigated. Here, we characterized compared a cohort local Chinese residents visiting Pakistani individuals, each group...
Humans are constantly exposed to antimicrobial triclocarban (TCC) via direct skin contact with personal care and consumer products, but the safety of long-term dermal exposure TCC remains largely unknown. Herein, we used a mouse model evaluate potential health risks from continuous application at human-relevant concentrations. After percutaneous absorption, circulated in bloodstream entered liver–gut axis for metabolic disposition. Nontargeted metabolomics approach revealed that perturbed...
Aging results in a loss of metabolic flexibility during fasting, characterized by the inability to acutely switch between substrates and reduced lipid mobilization. However, drivers these effects intracellularly remain unclear. Here, Caenorhabditis elegans , we show that coordinated inter-organelle dynamics causally initiates inflexibility with age. In young animals, peroxisomes emerge as priming orchestrators fasting response, simultaneously governing droplets (LDs) utilization...
Cancer cachexia is characterized by unintentional weight loss and wasting away of fat muscle tissues. Anorexia, or reduced food intake, often implicated as a contributor to the negative energy balance in this condition. However, what extent anorexia alone accounts for body different tissues, whether responsible other cachectic phenotypes such physical performance impairment remains insufficiently preclinical models patients. In study, we demonstrate critical need address these questions...
Abstract Cancer cachexia is an involuntary weight loss condition characterized by systemic metabolic disorder. A comprehensive flux characterization of this however lacking. Here, we systematically isotope traced eight major circulating nutrients in mice bearing cachectic C26 tumors (cxC26) and food intake-matched non-cachectic (ncxC26). We found no difference whole-body lipolysis proteolysis, ketogenesis, or fatty acid ketone oxidation tissues between the two groups. In contrast, compared...
Dioxins, a group of persistent organic pollutants, have been proved to correlate with ranges diseases by activating the aryl hydrocarbon receptor (AhR). However, previous dioxin toxicity studies primarily focused on activation AhR signaling pathways at gene and protein levels. The investigation underlying mechanisms metabolic level is still necessary. In this study, serum samples 48 47 healthy participants highest lowest levels based quartile distribution concentrations 215 male adults were...
Trachinotus ovatus is a major economically important cultured marine fish in the South China Sea. However, extreme weather and increased culture density result uncontrollable problems, such as increases water temperature decline dissolved oxygen (DO), hindering high-quality development of aquaculture. In this study, liver transcriptional profiles T. were investigated under acute high-temperature stress (31 °C 34 °C) normal (27 using RNA sequencing (RNA-Seq) technology. Differential...
Dioxins, environmentally stable and ubiquitous, have been found to induce metabolic changes especially in lipids be related multiple diseases. However, limited study is available on lipid alternations human exposure dioxins. This aims explore the serum lipidomic characterization understand underlying mechanisms of adverse health risks associated with dioxin exposure. A integrating nontargeted lipidomics, targeted free fatty acid (FFA) acyl-coenzyme (acyl-CoA) analyses were conducted...
Oxygen level is an important environmental factor affecting the circadian rhythm. However, little known about molecular mechanism by which clock genes regulate rhythm in fish under hypoxia. To explore changes transcription and expression of related regulatory mechanisms pearl gentian grouper hypoxia, liver transcriptome data were analyzed after exposure to acute hypoxic stress (dissolved oxygen 0.5 mg/L) for 1, 3, 6, 9 h. miR-210 m0044-5p inhibited period3 (per3) casein kinase 1 delta b...
Aminoglycosides are one of a few susceptible antimicrobials available for carbapenem-resistant Enterobacteriaceae (CRE). However, the altered pharmacokinetics and increasing drug resistance aminoglycosides will make them hardly effective if used in monotherapy. The purpose this study was to identify herbal compounds that potentiate antibacterial effect gentamicin against Klebsiella pneumoniae (CRKp) with explore action mechanisms.A collection 280 Chinese screened synergistic CRKp by broth...