A5101718848- Bioactive Natural Diterpenoids Research
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Biological Activity of Diterpenoids and Biflavonoids
- Plant-based Medicinal Research
- Marine Sponges and Natural Products
- Plant-derived Lignans Synthesis and Bioactivity
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Chemical Synthesis and Analysis
- Bioactive natural compounds
- Synthesis of Organic Compounds
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Fungal and yeast genetics research
- Bioactive Compounds and Antitumor Agents
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Bioactivity Studies
- Food Quality and Safety Studies
- Alkaloids: synthesis and pharmacology
- Receptor Mechanisms and Signaling
- Heat shock proteins research
- Neuroscience and Neuropharmacology Research
- Phytochemistry and Bioactive Compounds
- Biofuel production and bioconversion
Kunming Institute of Botany
2010-2023
Chinese Academy of Sciences
2010-2023
Zhejiang University
2022
The University of Queensland
2021
Nanjing Tech University
2016-2021
The First Affiliated Hospital, Sun Yat-sen University
2021
Sun Yat-sen University
2021
GTx (United States)
2020
AstraZeneca (United States)
2020
Institute of Cellular and Organismic Biology, Academia Sinica
2020
New N-hydroxypyridones, militarinones E (1) and F (2), phenylhydrazones, farylhydrazones A (3) B (4), a quinazolinone, 2-(4-hydroxybenzyl)quinazolin-4(3H)-one (5), the known (6) (7) were isolated from cultures of Cordyceps-colonizing fungus Isaria farinosa. The structures 1−5 elucidated by spectroscopic methods, 3 was confirmed X-ray crystallography. absolute configuration C-4′ secondary alcohol in 1 deduced via circular dichroism data situ formed [Rh2(OCOCF3)4] complex. Compounds 6 showed...
A hybrid polymer–MOFs architecture UiO-66-NH2@PMAA was synthesized by tethering polymethacrylic acid (PMAA) onto the surface of metal–organic frameworks UiO-66-NH2, and it further employed for pectinase immobilization electrostatic interactions. The prepared through a combination atom transfer radical polymerization (ATRP), click chemistry postsynthetic modification (PSM). optimal parameters were at 25 °C pH 4.0 with 10 U/mL 2 h, under which showed highest enzymatic activity (1.215 U/mg)...
A new polyoxygenated sterol, sterolic acid (1), three breviane spiroditerpenoids, breviones I–K (2–4), and the known (5–8), were isolated from crude extract of a Penicillium sp. obtained deep sea sediment sample that was collected at depth 5115 m. The structures 1–4 elucidated primarily by NMR experiments, 1 further confirmed X-ray crystallography. absolute configurations 2 3 deduced comparison their CD spectra with those model compounds. Compounds 5 showed significant cytotoxicity against...
Cytosporolides A−C (1−3), three caryophyllene-derived meroterpenoids with a unique peroxylactone skeleton, were isolated from cultures of the fungus Cytospora sp. Their structures elucidated by NMR spectroscopy, and absolute configuration 5,6-diol moiety in 1 was assigned using Snatzke's method. Compounds 1−3 showed significant antimicrobial activity against Gram-positive bacteria Staphylococcus aureus Streptococcus pneumoniae.
Background To isolate plant-derived compounds with antimicrobial activity from the leaves of Mikania micrantha, to determine configuration, and evaluate their against eight plant pathogenic fungi (Exserohilum turcicum, Colletotrichum lagenarium, Pseudoperonispora cubensis, Botrytis cirerea, Rhizoctonia solani, Phytophthora parasitica, Fusarium Pythium aphanidermatum,) four bacteria (gram negative bacteria: Ralstonia dolaanacearum, Xanthomonas oryzae pv. Oryzae, Campestris Vesicatoria,...
Six new lanostane-related triterpenoids, kadcoccinones A–F (1–6), were isolated from Kadsura coccinea. Compound 3 possesses a novel 6/6/9-fused carbocyclic core containing rare oxabicyclo[4.3.1]decane system. Compounds 4 and 5 are isomers representing the first example of 18(13 → 12)-abeo-26-norlanostane triterpenoid. The absolute configurations 1 4–6 defined by X-ray diffraction experimental ECD spectra, that was elucidated quantum chemical calculations. plausible biogenetic pathway 1–6 is...
Fourteen enmein-type 6,7-seco-ent-kaurane diterpenoids, seven new ones (sculponins M–S, 1–7) and known compounds (8–14), were isolated from the aerial parts of Isodon sculponeatus. Compound 1 is first example an ent-kauranoid, possessing a 11,12-epoxy group, 6 7 have rare 3,6-epoxy group. The structures established primarily by NMR MS methods, absolute configurations 1, 3, determined single-crystal X-ray diffraction. 14 showed significant cytotoxic activity against five human tumor lines,...
Six Diels–Alder adducts (1–6) and nine prenylated flavanones (7–15) were isolated from the root bark of Morus alba L. Among them, soroceal B (1) sanggenol Q (7) new compounds. Their structures elucidated on basis extensive spectroscopic methods, including 1D 2D NMR techniques. Compounds 1–3, 9, 10, 12, 13 15 exhibited cytotoxic activity against five human tumour lines compound 2 inhibited significantly selective activities towards HL-60 AGS cells with IC50 3.4 3.6 μM. 3, 5, 9 12 moderate...
Four new acylphloroglucinols with an unusual 6/6/5 spirocyclic skeleton, hyperbeanols A—D (1—4), were isolated from the methanol extract of Hypericum beanii along 16 known compounds. Their structures established on basis spectroscopic and X-ray diffraction analysis. Hyperbeanols A—C three stereoisomers different only at relative configuration C-4 C-13, which distinguished by nuclear Overhauser effect spectroscopy (NOESY) data in combination single analysis hyperbeanol A (1). The cytotoxic...
Twelve new diterpenoids, isoadenolins A–L (1–12), and 24 known ones were isolated from the aerial parts of Isodon adenolomus. Their structures identified using spectroscopic data, absolute configurations 1 14 determined by single-crystal X-ray diffraction. Selected compounds evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, SW-480 cell lines. Compounds 9, 13–16, 21 showed significant inhibitory effects on all five cells, with IC50 values range 0.7–9.7 μM.
Fourteen new rearranged 6/6/5/6-fused triterpenoid acids, namely, kadcoccine acids A–N (1–14), were isolated from an EtOAc-soluble extract of the stems Kadsura coccinea. Their structures characterized mainly by analyzing 1D and 2D NMR HRESIMS data shown to feature a rare 14(13→12)-abeo-lanostane skeleton. Compounds 7 8 represented first examples 5-substituted 2(5H)-furanone motif on C-17 side chain this The absolute configurations C-23 for compounds 1, 7, determined comparison their...
Eight new limonoids with four different structural frameworks, including gedunin (1, 2), havanensin (3, 4), mexicanolide (5, 6), and methyl angolensate types (7, 8), together six known limonoids, were isolated from the leaves of Cipadessa baccifera. Compounds 2 5 exhibited moderate cytotoxicity against HL-60 cell line an IC50 value 20 μM.
Three new abietane diterpenoids, isoabietenins A–C (1–3), and 13 ent-kauranoids, tenuifolins A–M (4–16), along with four known compounds (17–20), were isolated from the aerial parts of Isodon tenuifolius. The structures metabolites established on basis detailed spectroscopic analysis. absolute configurations 1, 15, 16 confirmed by single-crystal X-ray diffraction. Selected evaluated for their cytotoxicity against a small panel human tumor cell lines, some showed inhibitory effects....
Laxiflorolides A (1) and B (2), two unprecedented epimeric bishomoditerpene lactones with a unique C22 framework, along laxiflorins P–R (3–5), maoecrystal P (6), C (7), eriocalyxin (8), were isolated from the leaves of I. eriocalyx var. laxiflora. The structures 1 2, including absolute configurations, determined by spectroscopic methods single-crystal X-ray diffraction analysis. All compounds evaluated for their cytotoxicity against five tumor cell lines. Compounds 3, 6, 8 showed remarkable...
Isorosthin A (1), the first 20-nor-enmein-type diterpenoid, and 15 new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from aerial parts of Isodon rosthornii. The structures 1-16 elucidated by means spectroscopic analysis. relative configuration 2 absolute 3 determined single-crystal X-ray diffraction. Cytotoxicity evaluation against five human tumor lines showed inhibitory effects several compounds tested. Furthermore, 12 isolates exhibited activity...
Three new caryophyllene sesquiterpenoids, cytosporinols A-C (1–3), have been isolated from solid cultures of Cytospora sp. The structures 1–3 were elucidated primarily by NMR spectroscopy, and 3 was further confirmed X-ray crystallography. absolute configurations the C-11 secondary alcohol in 1 6,8-diol moiety deduced using modified Mosher Snatzke's method, respectively. Compounds 2 showed moderate cytotoxicity against HeLa cells.