A5078345113- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- Traditional and Medicinal Uses of Annonaceae
- X-ray Diffraction in Crystallography
- Chemical synthesis and alkaloids
- Advanced Synthetic Organic Chemistry
- Bioactive Natural Diterpenoids Research
- Synthetic Organic Chemistry Methods
- Phytochemistry and Bioactivity Studies
- Microbial Natural Products and Biosynthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Sesquiterpenes and Asteraceae Studies
- Pharmacological Effects of Natural Compounds
- Plant Gene Expression Analysis
- Alkaloids: synthesis and pharmacology
- Tryptophan and brain disorders
- Phytochemistry and Bioactive Compounds
- Connexins and lens biology
- Traditional Chinese Medicine Analysis
- Photosynthetic Processes and Mechanisms
- Bioactive Compounds and Antitumor Agents
- Nanoparticles: synthesis and applications
Kunming Institute of Botany
2014-2025
Chinese Academy of Sciences
2015-2025
Shanghai University of Traditional Chinese Medicine
2012-2024
Fudan University
2006-2024
State Key Laboratory of Genetic Engineering
2018-2024
University of Göttingen
2024
Universitätsmedizin Göttingen
2024
University of Chinese Academy of Sciences
2009-2024
Institute of Geochemistry
2024
Wuhan University
2024
Abstract Immunity deteriorates with age in animals but comparatively little is known about the temporal regulation of plant resistance to herbivores. The phytohormone jasmonate (JA) a key regulator insect defense. Here, we show that JA response decays progressively Arabidopsis . We this decay regulated by miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE9 (SPL9) group proteins, which can interact ZIM-domain (JAZ) including JAZ3. As SPL9 levels gradually increase, JAZ3 accumulates and...
Three unprecedented indole alkaloids, trigonoliimines A−C (1−3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures 1−3 determined by spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed modest anti-HIV-1 activity (EC50 = 0.95 μg/mL, TI 7.9).
Salvia miltiorrhiza Bunge, a perennial plant of Lamiaceae, accumulates abietane-type diterpenoids tanshinones in root, which have been used as traditional Chinese medicine to treat neuroasthenic insomnia and cardiovascular diseases. However, date the biosynthetic pathway is only partially elucidated mechanism for their root-specific accumulation remains unknown. To identify enzymes transcriptional regulators involved biosynthesis tanshinones, we conducted transcriptome profiling S. root leaf...
The Meliaceae family is rich sources of limonoid (meliacin), which are well know for their antifeedant activity and bitterness. Although existence also could be found in Rutaceae, Cneoraceae, Ptaeroxylaceae, Simaroubaceae family, they especially abundant structurally diversified the family. Structurally, highly oxygenated modified nortriterpenoids either containing or derived from a precursor with 4,4,8-trimethyl-17-furanylsteroid skeleton. Nearly three decades ago, Taylor divided so far...
Significance Cotton is an important crop, and terpenoids form the largest group of natural products. Gossypol related sesquiterpene aldehydes in cotton function as phytoalexins against pathogens pests but pose human health concerns, oil still widely used vegetable oil. We report isolation identification four enzymes recharacterization one previously reported P450. are now close to completion gossypol pathway, progress agricultural plant sciences, data beneficial improving food safety. Among...
Salvia miltiorrhiza Bunge, a perennial plant of Lamiaceae, accumulates abietane-type diterpenoids tanshinones in root, which have been used as traditional Chinese medicine to treat neuroasthenic insomnia and cardiovascular diseases.However, date the biosynthetic pathway is only partially elucidated mechanism for their root-specific accumulation remains unknown.To identify enzymes transcriptional regulators involved biosynthesis tanshinones, we conducted transcriptome profiling S. root leaf...
Two new quassinoids, javanicolide E (1) and F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco mosaic virus (TMV) activity these was screened by conventional half-leaf leaf-disk method Western blot analysis. All seventeen showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoside (5), yadanzioside I (6), L (7), D (8), yadanziolide A (9), aglycone (17), strong antiviral...
To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated MeOH extract of the wood Picrasma quassioides Benn. These compounds were screened for their inhibitory activities (TMV). The activity each compound TMV infection replication was tested using a half-leaf assay method, leaf-disk Western blotting analyses. All showed moderate anti-TMV exhibited synergistic effects when combined with...
Most TPSs (terpene synthases) contain plasticity residues that are responsible for diversified terpene products and functional evolution, which provide a potential improving catalytic efficiency. Artemisinin, sesquiterpene lactone from Artemisia annua L., is widely used malaria treatment progress has been made in engineering the production of artemisinin or its precursors. In present paper, we report new synthase A. annua, AaBOS (A. α-bisabolol synthase), high sequence identity with AaADS...
As sessile and autotrophic organisms, plants have evolved sophisticated pathways to produce a rich array of specialized metabolites, many which are biologically active function as defense substances in protecting from herbivores pathogens. Upon stimuli, these structurally diverse small molecules may be synthesized or constitutively accumulated. Jasmonate acids (JAs) the major phytohormone involved transducing external signals (such wounding) activate reactions, including, particular,...
Abstract A novel limonoid, perforanoid A, was isolated, and an asymmetric total synthesis achieved in 10 steps. The key steps are chiral tertiary aminonaphthol mediated enantioselective alkenylation of aldehyde to allylic alcohol, Pd‐catalyzed coupling the alcohol with vinyl ether form γ‐lactone ring, cyclopentenone ring formation through a Rh‐catalyzed Pauson–Khand reaction. Preliminary studies show that is cytotoxic towards HEL, K562, CB3 tumor cell lines.
Indoleamine 2,3-dioxygenase 1 (IDO1), which catalyzes the initial and rate-limiting step of kynurenine pathway tryptophan catabolism, has emerged as a key target in cancer immunotherapy because its role enabling cancers to evade immune system. Tryptophan (TDO) indoleamine 2 (IDO2) catalyze same reaction play potential immunotherapy. Starting from our previously discovered tryptanthrin IDO1 inhibitor scaffold, we synthesized novel N-benzyl/aryl substituted derivatives evaluated their...
Tanshinone ⅡA (TⅡA), a diterpene quinone with furan ring, is bioactive compound found in the medicinal herb redroot sage (Salvia miltiorrhiza Bunge), which both and dihydrofuran analogs are present abundance. Progress has been made recently elucidating tanshinone biosynthetic pathway, including heterocyclization of D-ring by cytochrome P450s; however, dehydrogenation to furan, key step ring formation, remains uncharacterized. Here, differential transcriptome mining, we identified six...
A new alkaloid, daphenylline (1), with an unprecedented rearranged 22-nor-calyciphylline skeleton, was isolated from the fruits of Daphniphyllum longeracemosum. Its structure and stereochemistry were elucidated on basis spectroscopic computational approaches. plausible biosynthetic pathway 1 also proposed.