A5083314108- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Plant Disease Resistance and Genetics
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Insect-Plant Interactions and Control
- Plant Pathogenic Bacteria Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cocoa and Sweet Potato Agronomy
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Phytoplasmas and Hemiptera pathogens
- Phytochemical compounds biological activities
- Genetic and Kidney Cyst Diseases
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Insect symbiosis and bacterial influences
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Fungal Plant Pathogen Control
Nanjing University of Chinese Medicine
2025
Shanghai Ninth People's Hospital
2025
National Clinical Research
2025
Shanghai Jiao Tong University
2025
Huzhou University
2025
Zhejiang University
2025
Beijing Forestry University
2025
Yunnan University of Traditional Chinese Medicine
2022-2024
Yunnan University
2019-2024
Institute of Medicinal Plant Development
2023-2024
<b><i>Background:</i></b> Hepatocellular carcinoma (HCC) (about 85–90% of primary liver cancer) is particularly prevalent in China because the high prevalence chronic hepatitis B infection. HCC fourth most common malignancy and third leading cause tumor-related deaths China. It poses a significant threat to life health Chinese people. <b><i>Summary:</i></b> This guideline presents official recommendations National Health Family Planning...
Abstract Background High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate mechanism by which hypoxia promotes HCC through inducing epithelial-mesenchymal transition (EMT). Methods The expression EMT markers was analyzed immunohistochemistry. Effect on induction ability cell migration were...
Two new quassinoids, javanicolide E (1) and F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco mosaic virus (TMV) activity these was screened by conventional half-leaf leaf-disk method Western blot analysis. All seventeen showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoside (5), yadanzioside I (6), L (7), D (8), yadanziolide A (9), aglycone (17), strong antiviral...
To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated MeOH extract of the wood Picrasma quassioides Benn. These compounds were screened for their inhibitory activities (TMV). The activity each compound TMV infection replication was tested using a half-leaf assay method, leaf-disk Western blotting analyses. All showed moderate anti-TMV exhibited synergistic effects when combined with...
Considerable research has been conducted concerning galectin-9 and carcinomas, but little information is available about any relation with the hepatocellular carcinoma. In this study, we employed a small interfering RNA (siRNA) targeting to down-regulate expression in HepG2 cells. As result, after was reduced, cell aggregation suppressed, while other behaviour such as proliferation, adhesion invasion ECM, cell-endothelial transendothelial of cells were markedly enhanced. When tumors 200...
Interaction between tumor cells and surrounding stromal fibroblast (SF) plays a critical role in growth invasion. The aim of the study is to determine SF regulating invasive behaviors pancreatic cancer by evaluating mode activating urokinase plasminogen activator (uPA)-plasmin-matrix metalloproteinase (MMP)-2 cascade.The expression patterns uPA, MMP-2, uPA receptor (uPAR) human metastatic were analyzed immunohistochemistry roles activation uPA-plasmin-MMP-2 cascade evaluated coculturing cell...
Five new benzylphenethylamine alkaloids, hostasine (1), 8-demethoxyhostasine, 8-demethoxy-10-O-methylhostasine, 10-O-methylhostasine, and 9-O-demethyl-7-O-methyllycorenine, along with 12 known compounds, were isolated from Hosta plantaginea by bioassay-guided fractionation. The structures of the alkaloids established means extensive spectroscopic methods, relative configuration 1 was further confirmed single-crystal X-ray diffraction. 7-Deoxy-trans-dihydronarciclasine (IC50 = 1.80 µM), a...
Purpose. The Src family kinase Fyn, heterogenous nuclear ribonucleoprotein (HnRNP) A2B1 and Sam68 are thought to be associated with the metastasis of tumors, but their roles in regulation apoptosis remain unclear. This study investigated role Fyn its potential relationship HnRNPA2B1 pancreatic cancer. Experimental design. We examined both activity expression human cancer tissues systematically apoptotic mechanisms induced by using multiple experimental approaches. Results. found that was...
A number of viral proteins from plant viruses, other than movement proteins, have been shown to traffic intracellularly along actin filaments and be involved in infection. However, there has no report that a capsid protein may within cell by utilizing the actin/endoplasmic reticulum (ER) network. We used Tomato spotted wilt tospovirus (TSWV) as model virus study biological properties nucleocapsid (N) protein. found TSWV N was capable forming highly motile cytoplasmic inclusions moved ER The...
Abraxas brother 1 (ABRO1) has been reported to be a component of the BRISC complex, multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. However, current knowledge functions ABRO1 is limited. Here we report frequently downregulated in human liver, kidney, breast and thyroid gland tumour tissues. Depletion cancer cells reduces p53 levels enhances clone formation cellular transformation. Conversely, overexpression suppresses cell proliferation p53-dependent manner. We...
Abstract Peanut production is threatened by climate change. Damage to seedlings from low temperatures in early spring can limit yield. Plant adaptations chilling stress remain unclear peanut seedlings. It essential understand how acquires tolerance. We evaluated effects of on growth and recovery compared analysed biological characteristics, antioxidants, photosynthesis, biochemical physiological responses, nutrient absorption at varying levels chilling. Compared with chilling‐sensitive FH18,...
Unlike chemical pesticides, antiviral plants are biodegradable, replenishable and safe. In this study, 14 sesquiterpene compounds from Tithonia diversifolia were tested for their activities against Tobacco mosaic virus (TMV) using the half-leaf method. Tagitinin C (Ses-2) 1β-methoxydiversifolin-3-0-methyl ether (Ses-5) found to have in vivo curative of 62.86% 60.27% respectively, at concentrations 100μg/mL, respectively. contrast, inhibition rate control agent ningnanmycin was 52.48%....
Abstract Background Rhizosphere and endophytic fungi play important roles in plant health crop productivity. However, their community dynamics during the continuous cropping of Knoxia valerianoides have rarely been reported. K. is a perennial herb family Rubiaceae has used herbal medicines for ages. Here, we high-throughput sequencing technology Illumina MiSeq to study structural functional rhizosphere valerianoides. Results The findings indicate that planting led an increase richness...
Feammox is a novel microbial process that enables simultaneous nitrogen and phosphorus removal in wastewater treatment. This study investigated the role of organic matter Feammox-driven nutrient during long-term bioreactor operation by gradually increasing influent chemical oxygen demand (COD) concentration from 0 to 50, then 100 mg/L. The results revealed ammonium efficiency was reduced 60.5 % 20.7 with COD In contrast, enhanced nitrate through heterotrophic denitrification, which...
Background The tyrosine receptor kinase inhibitor (TRKi) entrectinib is used to treat neurotrophic (NTRK) fusion-positive solid tumors and ROS1-positive patients. Despite its impressive efficacy against cancer, the clinical application still limited by central nervous system (CNS)-related toxicities. However, precise mechanism of such CNS-related toxicities remains elusive. Methods effect entrectinib-induced nerve cell damage was evaluated cells (PC12, HT22 SK-N-SH) based in vitro models....
Polygonatum is a traditional medicinal and edible plant often prepared by steaming it with ingredients like yellow rice wine black beans. However, the metabolic changes in kingianum (PK) during method beans have not been previously reported. This study aims to explore how addition of degree affect quality PK. quantified polysaccharides, reducing sugars, saponins, flavonoids PK subjected varied cycles, while also integrating color measurement, sensory evaluation, non-targeted metabolomics...