A5110308407- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cooperative Communication and Network Coding
- Advanced Wireless Network Optimization
- Advanced MIMO Systems Optimization
- Nerve Injury and Rehabilitation
- Power Systems and Technologies
- Congenital Anomalies and Fetal Surgery
- Wireless Communication Networks Research
- Gastric Cancer Management and Outcomes
- Intraocular Surgery and Lenses
- Inflammatory Biomarkers in Disease Prognosis
- Hepatitis B Virus Studies
- Glaucoma and retinal disorders
- Medical Research and Treatments
- Cancer-related molecular mechanisms research
- Peripheral Nerve Disorders
- Advanced Photonic Communication Systems
- Advanced Optical Network Technologies
Huazhong University of Science and Technology
2020-2025
Wuhan Children's Hospital
2025
Beijing Tsinghua Chang Gung Hospital
2017-2024
Tsinghua University
2017-2024
Third People's Hospital of Huzhou
2024
Huzhou University
2024
Zhejiang Sci-Tech University
2024
Beijing University of Chemical Technology
2023
Ministry of Ecology and Environment
2020-2021
Tianjin University
2021
Abstract Background High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate mechanism by which hypoxia promotes HCC through inducing epithelial-mesenchymal transition (EMT). Methods The expression EMT markers was analyzed immunohistochemistry. Effect on induction ability cell migration were...
Microcystins have been reported to be carcinogenic by animal and cell experimentation, but there are no data on the linkage between serum microcystins hepatocellular carcinoma (HCC) risk in humans. We conducted a clinical case-control study investigate association HCC after controlling several known factors, such as hepatitis B virus, alcohol, aflatoxin. From December 2013 May 2016, 214 patients newly diagnosed with along controls (frequency-matched age sex) were recruited from three...
Although the nephrotoxicity of microcystin and aflatoxin has been observed in animal clinical cases, few population data are available. We conducted a cross-sectional study Southwest China to investigate association renal function indicators (RFIs, including BUN, SCr, eGFR) with exposure 5493 members general population. Microcystin-LR levels water aquatic products B1 daily foods were measured by ELISA, individual estimated intake (EDI) was assessed on basis measurement questionnaire. found...
The objective of this study was to evaluate the efficacy combined therapy using Sorafenib and radiofrequency ablation (RFA) with curative intent for all detectable lesions in patients Barcelona Clinic Liver Cancer (BCLC) Stage 0-B1 hepatocellular carcinoma (HCC).One hundred twenty-eight HCC from 12 centers were enrolled retrospective study; 64 who received plus RFA (Sorafenib-RFA) compared a control group treated alone. two patient groups selected predefined criterion matched terms their...
As glyphosate's application becomes increasingly widespread across the globe, its potential adverse effects on humans have garnered growing concerns. Little evidence has revealed associations between glyphosate and glucose homeostasis. A total of 2094 individuals were recruited from NHANES 2013–2018. Urinary glyphosate, alkaline phosphatase (ALP), fasting plasma (FPG), insulin, glycated hemoglobin A1c (HbA1c) measured. Homeostatic model assessment beta-cell function (HOMA2-β), insulin...
This study aimed to investigate the clinical utility of simultaneous measurement alphafetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) for hepatocellular carcinoma (HCC) diagnosis in Chinese patients predominantly caused by hepatitis B virus infection a multi-center case-controlled study. Subjects were 1,153 individuals from three major hospitals China, including 550 cases HCC group, 164 Malignant disease 182 Benign 85 Chronic liver 173 Normal group. Serum levels AFP DCP measured...
Three liver hazards, two confirmed-hepatitis B virus (HBV) and aflatoxin (AFB), one rarely studied in populations-microcystin (MC), simultaneously exist tropical humid areas; however, there are no epidemiological data on their risks the same population. We conducted a community-based cross-sectional survey among 5493 adults rural towns statistically analyzed comparative combinative effects of three factors after detecting HBsAg HBV DNA titers, determining estimated daily intakes (EDIs) AFB1...
Hepatocellular carcinoma (HCC) is the fifth most common cancer and second cause of death from worldwide. Strategies to surveil diagnose HCC in an earlier stage are urgently needed since this when curable interventions can be offered achieve long-term disease-free survival. Over past few decades, research has suggested measuring alpha-fetoprotein (AFP) concentration performing abdominal ultrasound (US) as part routine surveillance every 6 months for high-risk patients, many guidelines...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in China. Evidence has shown that surgical resection and liver transplantation may offer best potential for treating HCC but are only available to patients whose tumors detected early. Over past few decades, although a series measures standardized management been implemented China, most with China still present advanced-stage disease, thus strategies screen diagnose at an earlier stage urgently needed when...
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has high morbidity mortality. In this study, the safety efficacy of a modification ALPPS (radiofrequency-assisted ALPPS, RALPPS) were assessed in patients with hepatocellular carcinoma (HCC).Patients who diagnosed HCC considered to have an insufficient future remnant (FLR) enrolled. stage I, radiofrequency ablation (RFA) device was used cauterise along planned transection plane form coagulum avascular area....
Altered sialylation is closely associated with tumor progression and invasiveness. Micro-RNAs endogenous regulators of gene expression have been implicated in human thyroid carcinoma The objective this study to examine the alterations miR-4299 ST6GALNAC family follicular during metastatic process. qRT-PCR showed differential expressional profiles three kinds cell lines (FTC-133,FTC-238, Nthy-ori 3-1) clinical tissue specimens(malignant borderline). altered levels ST6GALNAC4 were...