A5100411397- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Liver Disease and Transplantation
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Circular RNAs in diseases
- Plasma Applications and Diagnostics
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Plasma Diagnostics and Applications
- Organ Transplantation Techniques and Outcomes
- Mathematical Biology Tumor Growth
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Peking University Shenzhen Hospital
2025
Beijing Tsinghua Chang Gung Hospital
2017-2024
Tsinghua University
2006-2024
Peking Union Medical College Hospital
2024
Xuzhou Central Hospital
2021-2024
Nantong University
2024
Southern Medical University Shenzhen Hospital
2024
Sun Yat-sen University
2016-2023
Army Medical University
2012-2023
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells cancer therapy has become a strategy of great research interest. mRNA vaccines are potential choice for immunotherapy, due to their ability directly encode antigen proteins and stimulate strong response. However, the mode delivery lack stability key issues limiting its application. LNPs an excellent carrier, structural biocompatibility make them effective means...
The RNA-binding protein RBM10 can regulate apoptosis during the proliferation and migration of pancreatic cancer, endometrial osteosarcoma cells; however, molecular mechanism underlying lung adenocarcinoma is rarely reported. Recent studies have detected multiple truncated missense mutations in adenocarcinoma, but role unclear. This study mainly explored immune regulation development its influence on sensitivity to targeted therapy drugs.The transcriptome data CGAP were used analyze RNA-seq...
Differentially expressed genes (DEGs) in lung adenocarcinoma (LUAD) tumor stem cells were screened, and the biological characteristics of
Glioma is one of the most common types malignant primary central nervous system tumor, and prognosis for this disease poor. As autophagic drugs have been reported to induce glioma cell death, we investigated potential prognostic role autophagy-associated long non-coding RNA (lncRNA) in patients. In study, obtained 879 lncRNAs 216 autophagy genes from Chinese Genome Atlas microarray, found that 402 are correlated with genes. Subsequently, 10 value (PCBP1-AS1, TP53TG1, DHRS4-AS1, ZNF674-AS1,...
Purpose: Nanoparticle (NP)-based chemo-photothermal therapy (CPT) has been shown to be a promising non-invasive approach for antitumor treatment. However, NPs must overcome the limitations of opsonization, clearance reticuloendothelial system, and ineffective targeting tumor tissue sites. To solve these problems, stem cell membrane (SCM)-camouflaged polydopamine nanoparticles ( [email protected] NPs) carrying hydrophobic anticancer drug 7-ethyl-10-hydroxycamptothecin (SN38) were constructed...
Sonodynamic therapy offers a non-invasive approach to induce the death of tumor cells. By harnessing ultrasound waves in tandem with sonosensitizers, this method produces reactive oxygen species (ROS) that inflict oxidative damage upon cells, subsequently causing their demise. Ferroptosis is regulatory form cell differs from other forms, characterized by iron accumulation, ROS and lipid peroxidation. In presented research, nanoparticle formulation, parthenolide/ICG-CaCO3@lipid...
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), key in chaperone-mediated autophagy (CMA) pathway, is elevated breast tumor tissues. However, exact effects and mechanisms CMA during cancer metastasis remain largely unknown. In this study, we found LAMP2A level was significantly human tissues, particularly metastatic carcinoma. The increased also positively correlated with histologic grade ductal cancer. High levels predicted shorter...
Opposite roles of circular RNA MM-associated (circ-MYBL2) have been observed in different malignancies, and its role pancreatic adenocarcinoma (PA) is unknown. Our preliminary sequencing data revealed inverse correlation with microRNA-19a (miR-19a). This study was performed to explore the circ-MYBL2 PA crosstalk miR-19a. The accumulation miR-19a detected by RT-qPCR. Participation regulation gene methylation studied an overexpression assay, followed RT-qPCR MSP analyses. cell proliferation...
Upper limb lymphedema is a common complication after radical mastectomy in patients with breast cancer. In this study, we examined the efficacy of self-manual lymph drainage (MLD) modified for prevention upper lymphedema, scar formation, or shoulder joint dysfunction cancer patients.Breast scheduled were randomly apportioned to undergo physical exercise only (PE group, control; n = 500) self-MLD as well (MLD group; surgery. PE started undertake remedial exercises and progressive weight...
Integration of public genome-wide gene expression data together with Cox regression analysis is a powerful weapon to identify new prognostic signatures for cancer diagnosis and prognosis. Hepatitis B virus (HBV) major cause hepatocellular carcinoma (HCC), however, it remains largely unknown about the specific signature HBV-associated HCC. Using Robust Rank Aggreg (RRA) method integrate seven whole genome datasets, we identified 82 up-regulated genes 577 down-regulated in HCC patients....
Dioscin is a natural product isolated from traditional Chinese medicines and reported to have antitumor activities against several cancers. In the present study, we aimed investigate its potency colorectal cancers, especially effects on tumor glycolysis, elaborate related molecular mechanisms.The of dioscin were evaluated by cell proliferation assays colony formation in vitro mouse xenograft models vivo. The glycolysis determined measuring glucose absorption lactate generation. Cell...
Low family socio-economic status is a known factor that can contribute to increased mortality for patients with cardiovascular disease. However, in developing countries, the prognostic impact of level on pediatric HTx unclear. We conducted retrospective cohort analysis children younger than 18 years who underwent heart transplantation (HTx) at our center from October 1, 2005, May 31, 2023. To assess status, we followed up discharged until September 30, 2023, monitoring all-cause and...
Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the primary causes severe hypertension. In order to identify long noncoding RNAs (lncRNAs) that may be involved in development CTEPH, comprehensive lncRNA and messenger RNA (mRNA) profiling endothelial tissues from arteries CTEPH patients was conducted with microarray analysis. Differential expression 185 lncRNAs observed compared healthy control tissues. Further analysis identified 464 regulated enhancer‑like overlapping,...
Abstract This study aims to explore the predictive noninvasive biomarker for obstructive coronary artery disease (CAD). By using data set GSE90074, weighted gene co‐expression network analysis (WGCNA), and protein–protein interactive network, construction of differentially expressed genes in peripheral blood mononuclear cells was conducted identify most significant clusters associated with CAD. Univariate multivariate stepwise logistic regression analyses receiver operating characteristic...
The aberrant regulation of circular RNAs (circRNAs), ring structures formed by exon or intron back-splicing, has been identified as a novel characteristic multiple cancers. However, the role circRNAs in colorectal carcinoma remains to be elucidated. In present study, we investigated mRNA level and promotional effect RNA CSPP1 (circCSPP1) cell liver metastasis. By bioinformatic analysis 10 paired samples carcinoma, circCSPP1 significantly upregulated tissues, its upregulation was correlated...
Abstract Background Tumor cell density is a basic pathological feature of solid tumors. Chemotherapy, radiotherapy, and targeted therapy reduce tumor density, whereas unrestricted proliferation promotes this feature. The impact cells on the microenvironment following changes in still unclear. In study, we focused response key immune subsets to hepatocellular carcinoma (HCC). Methods We determined same area by section staining. then identified potential mediators using polymerase chain...
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has high morbidity mortality. In this study, the safety efficacy of a modification ALPPS (radiofrequency-assisted ALPPS, RALPPS) were assessed in patients with hepatocellular carcinoma (HCC).Patients who diagnosed HCC considered to have an insufficient future remnant (FLR) enrolled. stage I, radiofrequency ablation (RFA) device was used cauterise along planned transection plane form coagulum avascular area....