A5102951018- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Pleural and Pulmonary Diseases
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Pediatric health and respiratory diseases
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- Actinomycetales infections and treatment
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Protein Tyrosine Phosphatases
- Respiratory viral infections research
- Genomics, phytochemicals, and oxidative stress
Peking University Shenzhen Hospital
2010-2024
Anhui Medical University
2021-2024
Hong Kong University of Science and Technology
2023-2024
University of Hong Kong - Shenzhen Hospital
2022-2024
Qingdao Agricultural University
2024
Southern Medical University
2024
Southern Medical University Shenzhen Hospital
2024
Beijing Tsinghua Chang Gung Hospital
2023
Tsinghua University
2023
Guangzhou Medical University
2021
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells cancer therapy has become a strategy of great research interest. mRNA vaccines are potential choice for immunotherapy, due to their ability directly encode antigen proteins and stimulate strong response. However, the mode delivery lack stability key issues limiting its application. LNPs an excellent carrier, structural biocompatibility make them effective means...
The RNA-binding protein RBM10 can regulate apoptosis during the proliferation and migration of pancreatic cancer, endometrial osteosarcoma cells; however, molecular mechanism underlying lung adenocarcinoma is rarely reported. Recent studies have detected multiple truncated missense mutations in adenocarcinoma, but role unclear. This study mainly explored immune regulation development its influence on sensitivity to targeted therapy drugs.The transcriptome data CGAP were used analyze RNA-seq...
Abstract Detection and treatment of lung cancer still remain a clinical challenge. This study aims to validate exosomal microRNA‐96 (miR‐96) as serum biomarker for understand the underlying mechanism in progression. MiR‐96 expressions normal patients were characterized by qPCR analysis. Changes cell viability, migration cisplatin resistance monitored after incubation with isolated miR‐96‐containing exosomes, anti‐miR‐96 anti‐miR negative control (anti‐miR‐NC) transfections. Dual‐luciferase...
Autophagy-related long-chain noncoding ribonucleic acids play a vital role in the development of esophageal adenocarcinoma. This study aimed to construct prognostic model autophagy-related and identify potential therapeutical targets for We downloaded 261 RNA transcript samples clinical data 87 adenocarcinoma patients from Cancer Genome Atlas 307 genes www.autophagy.com. performed Kyoto Encyclopedia Genes Genomes Gene Ontology enrichment analyses Set Enrichment Analysis determine risk...
The aim of this study was to find the application value selective polyadenylation in immune cell infiltration, biological transcription function and risk assessment survival prognosis lung adenocarcinoma (LUAD). processed original mRNA expression data LUAD were downloaded, profiles 594 patient samples collected. (APA) events TCGA-NA-SEQ evaluated by site use Index (PDUI) values, invasion stromal cells tumor purity calculated group select differential genes. Lasso regression stratified...
[Objective] Using multi-omics research methods to explore cytolytic activity-related genes through the immunoregulatory factors HAVCR2 (TIM3) affecting survival and prognosis of lung adenocarcinoma. [Methods] We combined Cox single factor regression lasso feature selection algorithm screen out key activity in adenocarcinoma, applied clinical predictive value model, including onset risk, independent prognosis, relevance, signal transduction pathways, drug sensitivity, correlation immune...
Abstract Background Cancer‐associated fibroblasts (CAFs) are potential targets for cancer therapy. Due to the heterogeneity of CAFs, influence CAF subpopulations on progression lung is still unclear, which impedes translational advances in targeting CAFs. Methods We performed single‐cell RNA sequencing (scRNA‐seq) tumour, paired tumour‐adjacent, and normal samples from 16 non‐small cell (NSCLC) patients. were analyzed after integration with published NSCLC scRNA‐seq data. SpaTial enhanced...
Non-small-cell lung cancer (NSCLC) is a major cause for cancer-related deaths around the globe, partially due to frequent recurrence and metastasis. Leucine-rich-alpha2-glycoprotein 1 (LRG1) reportedly upregulated in several cancers including NSCLC; however, its functions NSCLC remain elusive. We used quantitative real-time PCR western blot assays evaluate expression patterns of LRG1 tumor tissues collected from patients, as well cell lines, examined effects on proliferation, migration,...
Curcumin is a novel drug for lung cancer treatment. However, the mechanism underlying anti-tumor effect of curcumin remains elusive. Previous evidences indicated that, methylating transferase DNMT1 downregulated by curcumin, and transcription factor 21 (TCF21) suppressed DNMT1. We hereby attempt to elucidate correlation between treatment TCF21 expression. Exosomes derived from curcumin-pretreated H1299 cells were used treat BEAS-2B cells, which induced proliferation, colony formation...
Non-small cell lung carcinoma (NSCLC) is a type cancer with high malignant behaviors. MicroRNAs (miRNAs) are known to be involved in progression of NSCLC. In order explore potential targets for the treatment NSCLC, bioinformatics tool was used analyze differential expressed miRNAs between NSCLC and adjacent normal tissues.
Abstract Background The tea plant ( Camellia sinensis (L.) O. Kuntze) is one of the most economically important woody crops. Plastic greenhouse covering cultivation has been widely used in areas northern China. Chlorophyll not only crucial pigment for green tea, but also plays an role growth and development plants. Currently, little known about effect plastic on chlorophyll leaves. Results To investigate leaves, color difference values, contents, gene expression, enzyme activities...
Abstract Background: Lung cancer is the primary cause of cancer-related morbidity and mortality globally. Approximately 30% patients with EGFR mutation (EGFRm) in NSCLC are diagnosed at an early stage candidates for curative-intent surgical resection; however, disease recurrence remains a substantial clinical challenge. Aumolertinib third-generation TKI that potently inhibits both sensitizing mutations (ex19del/L858R) resistance T790M. ARTS (NCT04687241) randomized, double-blind,...
Purpose:EGFR and anaplastic lymphoma kinase (ALK) alterations have been regarded as oncogenic drivers incorporated into clinical practices to manage nonsmall cell lung cancer (NSCLC). Alterations of these two genes were traditionally considered be mutually exclusive, but recent studies suggested that they can occur concomitantly. Here, we investigated the prevalence, features outcomes in response treatment NSCLC patients who harbor EGFR ALK co-alterations. Methods: We reviewed genomic...
Exosomes, released from various cell types, serve as vehicles of intercellular communication. Rearranged anaplastic lymphoma kinase (ALK) has been detected in exosomes cancer cells ALK-positive nonsmall lung (NSCLC), however, the functional consequence ALK not studied. This study aims to address whether exosomal release is affected by stress, and can modulate survival recipient vitro vivo. isolated ALK-containing H3122 with (Exo-Apo) or without (Exo-Ctrl) irradiation treatment, were...
Metastasis is one of the characteristics advanced cancer and primary cause cancer-related deaths from cancer, but mechanism underlying metastasis unclear, there a lack markers. PTPRT protein-coding gene involved in both signal transduction cellular adhesion. It also known as tumor suppressor that inhibits cell malignant proliferation by inhibiting STAT3 pathway. Recent studies have reported early metastatic seeding colorectal cancer; however, correlation between other types has not been...
Rationale: Scapular prolapse is a rare complication of thoracotomy. Only few cases scapular after thoracotomy have been reported. Here, we report the case 52-year-old male patient who underwent standard posterior for lung sarcomatoid carcinoma invading left upper chest wall. Patient concerns: The surgery was performed to remove some ribs and wall muscles; however, no reconstruction or repair defect performed. experienced sharp pain severe limitation movement shoulder within 1 month receiving...
As a key regulator of intercellular communication, exosomes are essential for tumor cells. In our study, we will explore the mechanisms from different sources on lung cancer. We isolated CD8