A5100456953- Cerebrovascular and Carotid Artery Diseases
- Ferroptosis and cancer prognosis
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Lung Cancer Treatments and Mutations
- Aortic aneurysm repair treatments
- Lung Cancer Diagnosis and Treatment
- Renal and Vascular Pathologies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Abdominal vascular conditions and treatments
- Pleural and Pulmonary Diseases
- Vasculitis and related conditions
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Vascular Anomalies and Treatments
The University of Texas Health Science Center at San Antonio
2022-2025
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
First People's Hospital of Chongqing
2023-2024
ORCID
2024
Hunan Cancer Hospital
2019-2023
Central South University
2020-2023
Capital Medical University
2022-2023
First Affiliated Hospital of Xi'an Jiaotong University
2018-2023
Zunyi Medical University
2023
Sepsis-induced myocardial injury (SIMI), a common complication of sepsis, may cause significant mortality. Ferroptosis, cell death associated with oxidative stress and inflammation, has been identified to be involved in SIMI. This study sought investigate the role ANXA1 small peptide (ANXA1sp) SIMI pathogenesis. In this study, mouse cardiomyocytes (H9C2 cells) were stimulated lipopolysaccharide (LPS) imitate vitro. It was shown that ANXA1sp treatment substantially abated LPS-triggered H9C2...
Abstract Background Currently, noninvasive imaging techniques and circulating biomarkers are still insufficient to accurately assess carotid plaque stability, an in-depth understanding of the molecular mechanisms that contribute instability is lacking. Methods We established a clinical study cohort containing 182 patients with artery stenosis. After screening, 39 stable 49 unstable plaques were included in discovery group, quantitative proteomics analysis based on data independent...
ABSTRACT Acute kidney injury (AKI) increases mortality risk and predisposes individuals to chronic disease. Metabolic pathways play a crucial role in AKI pathophysiology. Here, we investigate the potential of methylthioadenosine phosphorylase (MTAP) inhibition as novel renoprotective strategy AKI. Using mouse models, demonstrate that small molecule MTAP inhibitor significantly reduces markers improves renal histology. RNA sequencing reveals modulates associated with inflammation, oxidative...
Tendinopathy is mainly characterized by local pain, functional limitation and decreased athletic ability, which seriously affects the quality of life patients career athletes. Farrerol (FA), one main active compounds extracted from Rhododendron plants in family, has a wide range pharmacological activities, such as immunomodulatory, anti-inflammatory antiviral effects. However, effect FA on tendinopathy unclear. Here, we investigated mechanism tendon injury through collagenase-induced vivo...
Dacomitinib is a potent, irreversible and pan-HER tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). Currently, evidence its activity on brain metastasis lacking.NSCLC patients diagnosed at Hunan Cancer Hospital between July, 2019 2020 with enhanced MRI-detected prior to treatment laboratory-confirmed EGFR mutations were reviewed. In total, 14 EGFR-mutant NSCLC treated first-line dacomitinib. The first radiographic review...
Background: COPD has been identified as an etiology or related disease of bronchiectasis, and bronchiectasis classified a comorbidity COPD. In this study, we investigated the prevalence in different phenotypes subjects correlation between phenotypes, especially emphysema. Methods: patients were recruited from April 2012 to December 2015. The presence information statistically analyzed. separated into subgroups two ways: with without groups emphysema-predominant (emphysema index, EI≥9.9%)...
Air pollution is highly associated with respiratory diseases. However, the influence and mechanism of particulate matter aerodynamic equal to or less than 2.5 μm (PM2.5) in lung homeostasis remain unclear. Herein, we demonstrated induction pulmonary fibrosis (PF) by PM2.5 exposure. The animal model showed that exposure could activate oxidative stress inflammation response, promoting epithelial-mesenchymal transition accumulation collagen, high expression pro-fibrotic factors, pathological...
Genetic factors are known to be important in the development of gastric cancer (GC). Prostate stem cell antigen (PSCA) has been shown expressed diffuse-type GC, and PSCA variation is associated with susceptibility GC Japanese Korean populations. The aim this study was investigate association between gene polymorphisms a Tibetan population. We analyzed single-nucleotide 196 patients 246 controls population, using polymerase chain reaction/ligase detection reaction test. rs2294008 C/T...
Tamoxifen (TAM) resistance is a major challenge in the treatment of estrogen receptor‑positive (ER+) breast cancer. To date, to best our knowledge, there are only few studies available examining response patients with TAM‑resistant cancer chemotherapy, and guidelines do not specify recommended drugs for these patients. In present study, cells were shown exhibit increased proliferation invasion compared parent cells, expression c‑MYC was demonstrated play an important role TAM resistance....
Abstract This study aimed to investigate application of Onodera prognostic nutrition index (OPNI) and neutrophil-to-lymphocyte ratio (NLR) in evaluating risk postoperative complications Crohn’s disease (CD). Clinical data 108 CD patients 9 years were respectively reviewed. OPNI NLR within 1 week preoperatively. Average was 38.8 ± 8.2 significantly lower with: type B3; lymphopenia; decreased haemoglobin, prealbumin, albumin; daily enteral <500 kcal/d. 5.9 12.1 higher B3, neutrophilia,...
Purpose:EGFR and anaplastic lymphoma kinase (ALK) alterations have been regarded as oncogenic drivers incorporated into clinical practices to manage nonsmall cell lung cancer (NSCLC). Alterations of these two genes were traditionally considered be mutually exclusive, but recent studies suggested that they can occur concomitantly. Here, we investigated the prevalence, features outcomes in response treatment NSCLC patients who harbor EGFR ALK co-alterations. Methods: We reviewed genomic...
Abstract Background Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a rare vascular disorder, and the treatment strategies remain controversial. This study aimed to compare outcomes of conservative endovascular treatments in symptomatic patients with SISMAD. Methods Forty-two consecutive SISMAD who were admitted single center between October 2009 May 2018 enrolled this study. Based on their symptoms, 15 had treatment, 27 treatment. The baseline characteristics,...
To investigate computed tomography (CT) features of stage IA invasive mucinous adenocarcinoma (IMA) the lung and establish a predictive model.Fifty-three lesions from 53 cases IMA between January 2017 December 2019 were examined, while 141 non-mucinous (INMA) served as control cases. Univariate analysis was performed to compare differences in demographics CT two groups, multivariate logistic regression determine primary influencing factors solitary nodular IMA. A risk score prediction model...
Alveolar soft part sarcoma (ASPS) is a rare tissue neoplasm. The incidence of orbital involvement the highest in ASPS arising head and neck region. However, limited information available regarding its clinical characteristics. present study presents manifestations, imaging findings, pathological features, treatment strategies prognosis records 8 cases over last 15 years single hospital, along with review literature. Included were 3 male 5 female patients, median age at presentation being 9.5...
Abstract Objectives Our aim was to investigate the prevalence and predictive variables of sarcopenia. Methods We recruited participants from Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass quantified using bioimpedance, muscle function grip strength gait speed. Logistic regression revealed relationships between sarcopenia nutritional, lifestyle, disease, psychosocial physical variables. Results The sarcopenic obesity 9.2%‐16.2%...
The effects of FBXO43 on hepatocellular carcinoma (HCC) and its clinical significance have not yet been determined. This study aims to determine the in HCC impact biological functions cells.Data from TCGA database were downloaded investigate expression correlation with prognosis immune infiltration. Immunohistochemical staining images acquired HPA website. cells (BEL-7404 SMMC-7721) transfected lentivirus targeting decrease cells. Western blotting assay was conducted evaluate level protein....
Abstract Our aim was to investigate the clinical efficacy of double filtration plasmapheresis (DFPP) in treatment antineutrophil cytoplasmic autoantibody‐(ANCA) associated vasculitis (AAV) with severe renal involvement. Fifteen AAV patients who had failure (median SCr 5.6(IQR 5.2–9.0) mg/dL) and needed initial replacement therapy (RRT) were treated DFPP immunosuppressive therapy. Two plasma volumes processed during each session. The changes serum ANCA function investigated. After for three...
Body mass index (BMI) and blood biomarkers are not enough to predict cardiovascular disease risk. Apolipoprotein B was identified be associated with (CVD) progression. The Dual-energy X-ray Absorption (DXA) results could considered as a predictor for in more refined way based on fat distribution. prediction of CVD risk by simple indicators still cannot meet clinical needs. association ApoB specific depot features remains explored better co-predict An amount 5997 adults from National Health...