A5101427101- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Poxvirus research and outbreaks
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Acute Myeloid Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- Hepatitis B Virus Studies
- Spine and Intervertebral Disc Pathology
- Indigenous Studies and Ecology
- Circular RNAs in diseases
- Nutrition and Health in Aging
- Polysaccharides and Plant Cell Walls
- Seaweed-derived Bioactive Compounds
- Gold and Silver Nanoparticles Synthesis and Applications
- Acute Lymphoblastic Leukemia research
- Clostridium difficile and Clostridium perfringens research
- RNA Interference and Gene Delivery
- Virology and Viral Diseases
- Mycobacterium research and diagnosis
- Biosensors and Analytical Detection
- vaccines and immunoinformatics approaches
Northwest A&F University
2022-2025
Lanzhou University
2024
First Hospital of Lanzhou University
2024
Yuhuangding Hospital
2022-2024
Qingdao University
2022-2024
Chinese Academy of Agricultural Sciences
2023
Institute of Animal Sciences
2023
China Minmetals (China)
2021-2022
Anhui University
2012-2022
Hefei Institutes of Physical Science
2020-2022
Abstract Hybridization chain reaction (HCR) was a significant discovery for the development of nanoscale materials and devices. One key challenge HCR is vulnerability to background leakage in absence initiator. Here, we systematically analyze sources refine leak-resistant rule by using molecular thermodynamics dynamics, biochemical biophysical methods. Transient melting DNA hairpin revealed be underlying cause that this can mitigated through careful consideration sequence thermodynamics. The...
DHAV-3 is one of the main causative agents duck viral hepatitis (DVH), an acute and highly lethal infectious disease in industry. However, understanding pathogenesis this virus ducklings limited. To dissect molecular characteristics associated with pathobiology to DHAV-3, we applied single-cell RNA-sequencing approach profile transcriptome 1.4 million cells from 14 livers susceptible (S) resistant (R) during infection 4 uninfected healthy controls. We found that infected S ducks exhibited...
Contagious ecthyma (CE) is an acute infectious zoonosis caused by orf virus (ORFV) that mainly infects sheep and goats causes obvious lesions low market value of livestock, resulting in huge economic losses for farmers. In this study, two strains ORFV were isolated from Shaanxi Province Yunnan China, named FX LX. The ORFVs located the major clades domestic respectively, exhibited distinct sequence homology. We analyzed genetic data core genes (B2L, F1L, VIR, ORF109) variable (GIF, ORF125...
Long non-coding antisense RNAs in the INK4 locus (lnc-ANRIL) have been reported to be involved inflammation and immunity. However, few studies its clinical application pediatric inflammatory bowel disease (IBD). Therefore, we conducted this study investigate correlation between lnc-ANRIL expression risk, inflammation, activity IBD patients.Pediatric patients with Crohn's (CD; n = 40), ulcerative colitis (UC; controls (n 20) were recruited. For all patients, peripheral blood mononuclear cells...
Orf is a zoonotic and highly contagious disease caused by virus (ORFV) infection. outbreaks in sheep goats usually lead to high culling rate mortality newborn kids lambs, posing great threat the development of goat industry. Human occurs via direct contact with infected animals or fomites. While this traditionally thought spread through contact, whether other transmission routes exist remains unclear. Herein, we report detection ORFV saliva milk dairy without clinical symptoms. Further...
The gut microbiome is a large and complex organic assemblage with subtle close relationships the host. This symbiotic mechanism important for health adaptability of host to environment. Compared other ruminants, there are few studies on yak intestinal microbes. study microbiota will help us better understand correlation between environmental In this study, we adapted 16S rDNA sequencing technology investigate diversity composition microbial community in free-range yaks captive living...
Abstract Objectives Our aim was to investigate the prevalence and predictive variables of sarcopenia. Methods We recruited participants from Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass quantified using bioimpedance, muscle function grip strength gait speed. Logistic regression revealed relationships between sarcopenia nutritional, lifestyle, disease, psychosocial physical variables. Results The sarcopenic obesity 9.2%‐16.2%...
As the most prevalent pathogen of duck viral hepatitis (DVH), A virus genotype 3 (DHAV-3) has caused huge economic losses to industry in China. Herein, we obtained whole-transcriptome sequencing data susceptible (S) and resistant (R) Pekin duckling samples at 0 h, 12 24 h after DHAV-3 infection. We found that infection induces 5,396 differentially expressed genes (DEGs), 85 miRNAs (DEMs), 727 lncRNAs (DELs) hpi S vs R ducks, those upregulated were enriched inflammation cell communications...
ABSTRACT Corynebacterium pseudotuberculosis ( C. p ), a facultative intracellular bacterium, is an important zoonotic pathogen that causes abscesses and pyogenic granulomas. The relationship between gut microbiota host health or diseases has received increasing attention. However, the role of in process infection still unclear. In this study, we established model C57BL/6 mice examined impact preemptive oral administration Lactobacillus acidophilus L. ) on infection. Our findings revealed led...
Anterior cruciate ligament (ACL) tear is a common sports-related injury, and cartilage injury always emerges as serious complication following ACL tear, significantly impacting the physical psychological well-being of affected individuals. Over years, efforts have been directed toward finding strategies to repair after tear. In recent times, procyanidins, known for their anti-inflammatory antioxidant properties, emerged potential key players in addressing this concern. This article focuses...
Surface-enhanced Raman spectroscopy (SERS) is a technology that can enhance the analyte signal with help of noble nanomaterials. Due to merits fingerprint recognition, high sensitivity, accuracy, fast and non-destructive detection, no interference from water. More more attentions are being paid SERS, especially in application trace drug-detection on site forensic science. SERS not only used for detection pure solutions, but also gradually expanded complex, including seized drugs human...
The purpose of this study was to evaluate the correlation long non-coding RNA maternally expressed gene 3 (Lnc-MEG3) with disease features, treatment response, and survival in pediatric acute myeloid leukemia (AML) patients.Among 92 de novo AML patients (before after 1 course induction) 40 controls, bone marrow mononuclear cells were obtained. Then, Lnc-MEG3 expression determined by reverse transcription quantitative polymerase chain reaction. After standard induction therapy patients,...
Nonlinear DNA signal amplification with an enzyme-free isothermal self-assembly process is uniquely useful in nanotechnology and nanomedicine.
Currently, the only available commercial vaccines for Orf virus (ORFV) are live attenuated vaccines, which present a potential risk of reversion to virulence. Therefore, understanding pathogenic mechanisms different virulent strains ORFV and host immune responses triggered by these viruses is crucial developing new interventions. In this study, we found that strain downregulates innate response antiviral activity. addition, noted wild-type can induce pattern centered on interferon-stimulated...
Abstract Background There have been controversial voices on if hepatitis B virus infection decreases the risk of colorectal liver metastases or not. This study aims to find association between HBV and postoperative survival cancer in patients. Methods Patients who underwent curative surgical resection for January 2011 December 2012 were included. grouped according anti-HBc. Differences overall survival, time progress, hepatic metastasis-free groups significant predictors analyzed. Results...
Abstract Purpose: This study aims to the find association between HBV infection and postoperative survival risk of liver metastasis in colorectal cancer patients. Methods: Patients who underwent curative surgical resection for (CRC) January 2011 December 2012 were included. grouped according anti-HBc. Differences overall (OS), time progress (TTP) hepatic metastasis-free (HMFS) groups significant predictors analyzed. Results: 327 patients are comprised 202 anti-HBc negative cases 125 positive...
Abstract Objective Long non‐coding RNA microvascular invasion in hepatocellular carcinoma (lnc‐MVIH) is correlated with unfavorable prognosis several malignancies, while limitedly studied pediatric acute myeloid leukemia (AML). This study aimed to investigate the correlation of lnc‐MVIH disease features, response induction therapy, and survival AML patients. Methods A total 129 de novo patients who were retrospectively analyzed 60 children non‐malignant hematological diseases underwent bone...
采用RACE技术克隆获得中国明对虾(Fenneropenaeus chinensis)谷氨酸脱氢酶GDH基因(FcGDH)。FcGDH基因全长1779 bp，包括1个1659 bp的开放阅读框(ORF)，编码552个氨基酸，预测分子量大小为61.3 kDa，理论等电点为6.54。同源性分析显示，FcGDH氨基酸序列与其他动物高度保守，其中，与凡纳滨对虾最为相似，高达98%，其次为中华绒螯蟹，为89%。系统进化树分析显示，FcGDH氨基酸序列与凡纳滨对虾GDH聚为一支，之后依次为：中华绒螯蟹、黑腹果蝇、埃及按蚊。组织表达分析发现，FcGDH基因在肌肉、鳃、肝胰腺、胃、肠、淋巴和血淋巴中均有表达，其中，肌肉中表达量最高。氨氮胁迫后，FcGDH基因在肌肉和肝胰腺组织中变化显著，在胁迫后期，FcGDH基因表达量均上调，且与对照组相比差异显著(P < 0.05)，说明FcGDH基因在氨氮解毒代谢过程中发挥了重要作用。
The purpose is to introduce a novel scaphoid screw placement surgery based on three-dimensional (3D) printing guiding template through dorsal approach, and evaluate the clinical feasibility accuracy. diagnose of fracture was confirmed by Computed Tomography (CT) scanning, subsequently CT scanning data input into three-dimension imaging system(Hongsong software, China). An individualized 3D skin surface with hole printed. We put correct position patient’s wrist. Fluoroscopy used confirm...