A5101766918- Microfluidic and Bio-sensing Technologies
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Isotope Analysis in Ecology
- Microfluidic and Capillary Electrophoresis Applications
- Metabolomics and Mass Spectrometry Studies
- 3D Printing in Biomedical Research
- Marine and coastal ecosystems
- Topology Optimization in Engineering
- Advanced Chemical Sensor Technologies
- Computational Drug Discovery Methods
- Analytical chemistry methods development
- Spectroscopy and Chemometric Analyses
- Nanopore and Nanochannel Transport Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Assistive Technology in Communication and Mobility
- Hydrocarbon exploration and reservoir analysis
- Gene Regulatory Network Analysis
- Leaf Properties and Growth Measurement
- GABA and Rice Research
- Machine Learning in Materials Science
- Opinion Dynamics and Social Influence
- Advanced Image Fusion Techniques
- Synthesis and biological activity
- Petroleum Processing and Analysis
University of Arizona
2025
China University of Petroleum, Beijing
2018-2024
University of Manchester
2022-2024
John Wiley & Sons (United States)
2020
Hudson Institute
2020
University of Science and Technology of China
2019
University of California, Berkeley
2012-2018
Guangzhou Institutes of Biomedicine and Health
2017
Xidian University
2015
Peking University
2009-2012
Journal Article Single-cell level co-culture platform for intercellular communication Get access Soongweon Hong, Hong Berkeley Sensor and Actuator Center, Department of Bioengineering, University California at Berkeley, 94720, USA. Tel: (510) 642-5855 Search other works by this author on: Oxford Academic Google Scholar Qiong Pan, Pan 642-5855College Chemistry Molecular Engineering, Peking University, Beijing, 100871, People's Republic China Luke P. Lee E-mail: lplee@berkeley.edu Integrative...
Environmental contextEstuaries play an important role in global carbon cycling terms of transforming dissolved organic matter (DOM). We describe the molecular composition and spatial distribution DOM Pearl River Estuary, area severely impacted by anthropogenic activities, show how gradually changes with salinity. The results will help our understanding sources transformations discharged to coastal seas. AbstractThe is second-largest river China water discharge brings enormous amounts...
Molecular composition of dissolved organic matter (DOM) is a hot topic in subjects such as environmental science and geochemistry. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been applied to molecular characterization DOM successfully. However, high instrument maintenance costs have constrained its wider application. A high-resolution Orbitrap spectrometer (Orbitrap can provide approximately 500,000 resolving power (at m/z 200), which potentially capable...
DHAV-3 is one of the main causative agents duck viral hepatitis (DVH), an acute and highly lethal infectious disease in industry. However, understanding pathogenesis this virus ducklings limited. To dissect molecular characteristics associated with pathobiology to DHAV-3, we applied single-cell RNA-sequencing approach profile transcriptome 1.4 million cells from 14 livers susceptible (S) resistant (R) during infection 4 uninfected healthy controls. We found that infected S ducks exhibited...
In this report, we disclose the design and synthesis of a series pentafluorosulfanyl (SF5) benzopyran derivatives as novel COX-2 inhibitors with improved pharmacokinetic pharmacodynamic properties. The compounds showed both potency selectivity for demonstrated efficacy in several murine models inflammation pain. More interestingly, one compounds, R,S-3a, revealed exceptional adjuvant induced arthritis (AIA) model, achieving an ED50 low 0.094 mg/kg. addition, pharmacokinetics compound R,S-3a...
New tools for measuring protein expression in individual cells complement single-cell genomics and transcriptomics. To characterize a population of mammalian cells, hundreds to thousands microwells are arrayed on polyacrylamide-gel-coated glass microscope slide. In this "open" fluidic device format, we explore the feasibility mitigating diffusional losses during lysis polyacrylamide-gel electrophoresis (PAGE) through spatial control pore-size gel layer. reduce in-plane diffusion-driven...
We report a highly effective on-chip preconcentration method by combining field-amplified sample injection (FASI) and bovine serum albumin (BSA) sweeping for ultrasensitive detection of green fluorescent protein (GFP) on simple cross-channel microchip device. With the formation stagnant sample/running buffer boundary balancing hydrodynamic flow electro-osmotic (EOF), GFP molecules can be continuously injected into loading channel stacked. have also demonstrated that BSA is very...
Inaccuracies in ion detection and signal processing can undermine confidence the molecular formula assignment of high-resolution mass spectrometry, which relies on precise matching mass-to-charge ratio (m/z). This study proposes a novel graph-based spectra calibration method, MSCMcalib, implements coordinate transformation pattern detection. MSCMcalib maps uncalibrated m/z data onto modified 2D defect plot, facilitating automatic detected lines, i.e., peaks aligned with these lines. The...
Because of the extremely low signal-to-noise ratio pulsar signals, it is difficult to suppress noise while preserving details by traditional denoise methods. Therefore, a wavelet domain signal denoising method based on differentiable thresholding function and an adaptive threshold selection technique presented. The ratio(SNR), root mean square error(RMSE), relative error peak value (REPV) position (EPP) are used evaluate performance proposed method. Experimental results show that can remove...
We report a novel on-line electrophoretic sample clean-up approach for highly sensitive and reproducible microchip (μCE) immunoassay of low-abundance proteins in human serum. The method takes advantage the differential effect field-amplified stacking on molecules with different mobility. Large interfering are removed from loading channel by simple voltage control, resulting selective concentration injection smaller target analytes to separation channel. As proof concept, an antibody-free...
Metabolites in the xylem experience several migration and transformation processes during tree growth. Their composition distributions can reflect environment that wood lived through. Herein, a matrix-assisted laser desorption/ionization mass spectrometry imaging method was developed to investigate of metabolites heartwood formation after mechanical injury. The thickness slice, type matrix its manner deposition were optimized improve ionization response spatial resolution. difference...
Estimation of pure component physiochemical properties has received much attention in the last decades as they serve basis for design chemical products and processes. In this work, we propose a connectivity matrix-based framework coupled with machine learning automatic creation molecular features used to accurately estimate properties. The concept matrix is employed represent molecule structure. An extraction strategy proposed extract plethora submatrices (or structural fragments) each...
Shell structures with a high stiffness-to-weight ratio are desirable in various engineering applications. In such scenarios, topology optimization serves as popular and effective tool for shell design. Among the methods, solid isotropic material penalization method(SIMP) is often chosen due to its simplicity convenience. However, SIMP method typically integrated conventional finite element analysis(FEA) which has limitations computational accuracy. Achieving accuracy FEA needs substantial...
Many complex networks in the real world demonstrate similar patterns, including scale-free property and strong community structure. In this paper, we present a novel parameter-free detection algorithm based on of networks, named ScaleFreeCDA. The basic idea behind it is two mechanisms, i.e., node growth preferential attachment. Community centers are firstly determined by degree similarity, then structures obtained accordingly. experiments indicate that our can find high-quality communities,...
Abstract. Leaf area index (LAI) is an important parameter related to carbon, water and energy exchange between canopy atmosphere, widely applied in the process models simulate production hydrological cycle forest ecosystems. However, fine-scale spatial heterogeneity of LAI its controlling factors have not been fully understood Chinese subtropical forests. We used hemispherical photography measure values three forests (i.e. Pinus massoniana – Lithocarpus glaber coniferous evergreen...