A5100766915- Advanced MRI Techniques and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Muscle Physiology and Disorders
- Metabolomics and Mass Spectrometry Studies
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Crystallography and molecular interactions
- Microfluidic and Capillary Electrophoresis Applications
- Advanced NMR Techniques and Applications
- Organometallic Complex Synthesis and Catalysis
- MRI in cancer diagnosis
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Acute Ischemic Stroke Management
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Mass Spectrometry Techniques and Applications
- Muscle metabolism and nutrition
- Body Composition Measurement Techniques
- Folate and B Vitamins Research
First Affiliated Hospital of Zhengzhou University
2023-2024
Huashan Hospital
2024
Fudan University
2024
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Kaohsiung Medical University
2011-2024
Institute of Hematology & Blood Diseases Hospital
2024
Ningbo University
2022-2023
Sun Yat-sen University
2021-2023
Beijing Hospital
2022
To prospectively investigate the apparent diffusion coefficient (ADC) and choline levels measured at hydrogen 1 ((1)H) magnetic resonance (MR) spectroscopy, to monitor therapeutic responses of hepatocellular carcinoma (HCC) transcatheter arterial chemoembolization (TACE).Institutional review board approval was obtained, all patients control subjects provided informed consent. Histologically proved large HCCs (>3 cm in diameter) were evaluated 20 (16 men four women; mean age, 59 years; range,...
To determine if in vivo detection of choline by using hydrogen 1 (1H) magnetic resonance (MR) spectroscopy with dynamic contrast material-enhanced MR imaging can help differentiate between benign and malignant musculoskeletal tumors.MR was performed 36 consecutive patients bone soft-tissue tumors larger than 1.5 cm diameter. Examinations were at T a surface coil appropriate for the location lesions. Single-voxel 1H point-resolved spectroscopic sequence echo times 40, 135, 270 msec. The...
Abstract Purpose To investigate the value of in vivo proton magnetic resonance spectroscopy (MRS) assessment large focal hepatic lesions and to measure metabolite change hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) using 3.0‐T scanner. Materials Methods In this prospective study, 43 consecutive patients with (not less than 3 cm diameter) tumors eight normal volunteer were included. MRS addition uninvolved liver parenchyma was carried out a whole‐body...
This study aimed to determine the impact of nutrition supplementation (whey protein, fish oil, vitamin D) and physical exercise (resistance aerobic exercise) on muscle mass, strength fat mass among sarcopenic elderly. Participants (N = 241) with sarcopenia (aged ≥ 60 y) enrolled from 2 centers were randomized into groups undergoing (Nutr), (Ex), combined (Nutr+Ex), or routine consultation for 12 weeks. Muscle-related indicators, grip as well fat-related indicators compared pre-...
Goose liver oil (GLO) is a solid-liquid mixture, rich in polyunsaturated fatty acids and high nutritional value, but poor fluidity easily oxidized. Therefore, oil-in-water (O/W) Pickering emulsions of three polysaccharides soy protein isolate (SPI) with GLO were prepared to improve the stability it.Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), Fourier-transform infrared spectroscopy, zeta potential revealed that SPI complexes konjac glucomannan, pectin, guar gum (GG)...
Abstract The quantification of choline‐containing compounds (Cho) in hepatic tumors by 1 H MR spectroscopy (MRS) is great interest because such have been linked to malignancy. In this study, a practical external phantom replacement method for the absolute metabolites demonstrated. We performed experiments at 3 T using body coil, and used an containing choline chloride calibration. first tested strategy confirm its suitability vivo known concentration normal brain tissue. results obtained...
Lung cancer is one of the most common malignant tumors. Despite decades research, treatment lung remains challenging. Non-small cell (NSCLC) primary type and a significant focus research in treatment. The deubiquitinase ubiquitin-specific protease 28 (USP28) plays role progression various tumors serves as potential therapeutic target. This study aims to determine USP28 NSCLC. We examined impact inhibitor AZ1 on cycle, apoptosis, DNA damage response, cellular immunogenicity non-small cancer....
To investigate the correlation between muscle function and metabolism in tissue of Duchenne muscular dystrophy (DMD) patients by vivo proton magnetic resonance spectroscopy. Materials Methods: In this prospective study, we enrolled 8 boys with DMD healthy volunteers. spectroscopy soleus muscles was performed using a whole-body 3.0-Tesla imaging unit knee coil. The levels trimethyl ammonium (TMA) total creatine (tCr) were measured. We compared TMA/water, tCr/water, TMA/tCr ratios, scores for...
Abstract It is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise acute injury are both known to induce regeneration, the molecular signals help trigger have remained unclear. Here, mass spectrometry imaging (MSI) used show injured a specific subset of prostanoids during including PGG1, PGD2, prostacyclin PGI2. The spike in promotes skeletal via myoblasts, aging. Mechanistically, PPAR γ /PGC1a signaling, which...
A series of amido phosphinoxide and phosphinimine ligands that are electronic variations monoanionic N,O- N,N-ketiminates have been prepared employed to examine the coordination chemistry aluminium. Oxidation previously established N-(2-diphenylphosphinophenyl)-2,6-dialkylaniline in presence H(2)O(2) or organic azides RN(3) (R = 2,6-C(6)H(3)(i)Pr(2), SiMe(3)) led phosphinoxides (H[NO] 1a-b) phosphinimines (H[NN] 1c-d), respectively. Alkane elimination reactions these protio-ligand precursors...
This work describes preparation and reaction chemistry of a terminal nickel(II) anilide complex supported by an unsymmetrically substituted diarylamido diphosphine ligand, [N(o-C6H4PPh2)(o-C6H4PiPr2)]− ([Ph-PNP-iPr]−). Treatment NiCl2(DME) with H[Ph-PNP-iPr] in THF at room temperature produced [Ph-PNP-iPr]NiCl as green crystals 82% yield. Salt metathesis LiNHPh(THF) −35 °C generated cleanly [Ph-PNP-iPr]NiNHPh greenish blue solid. The deprotonates protic (e.g., PhOH PhSH) aprotic...
Kinking of the cervical carotid or vertebral artery is a common structural abnormality in patients with cerebrovascular disease. However, there no consensus about relationship between kinking and ischemic stroke/TIA. We aim to determine effect arterial on
Abstract An easy method to fabricate poly(dimethylsiloxane) (PDMS)‐based microfluidic chips for protein identification by tandem mass spectrometry is presented. This microchip has typical electrophoretic microchannels, a flow‐through sampling inlet, and sheathless nanoelectrospray ionization (ESI) interface. The surface of the microchannel was modified with 2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid (AMPS) generated electroosmotic flow under acidic buffer condition used separation found be...
Abstract Objectives Our aim was to investigate the prevalence and predictive variables of sarcopenia. Methods We recruited participants from Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass quantified using bioimpedance, muscle function grip strength gait speed. Logistic regression revealed relationships between sarcopenia nutritional, lifestyle, disease, psychosocial physical variables. Results The sarcopenic obesity 9.2%‐16.2%...