A5035692823- Muscle Physiology and Disorders
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Pluripotent Stem Cells Research
- Mass Spectrometry Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Machine Learning in Materials Science
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- RNA modifications and cancer
- Suicide and Self-Harm Studies
- Pregnancy and preeclampsia studies
- Schizophrenia research and treatment
- RNA Research and Splicing
- Body Composition Measurement Techniques
- Congenital heart defects research
Chinese Academy of Sciences
2021-2025
Institute of Zoology
2021-2025
State Key Laboratory of Stem Cell and Reproductive Biology
2022-2025
University of Chinese Academy of Sciences
2021-2024
Zunyi Medical University
2024
Guangxi Zhuang Autonomous Region Brain Hospital
2023
Center for Excellence in Molecular Cell Science
2021
Skeletal muscle myofibers are heterogeneous in their metabolism. However, metabolomic profiling of single has remained difficult. Mass spectrometry imaging (MSI) is a powerful tool for molecular distributions . In this work, we optimized the workflow matrix-assisted laser desorption/ionization (MALDI)–based MSI from cryosectioning to metabolomics data analysis perform high–spatial resolution slow- and fast-twitch myofibers. Combining advantages liquid chromatography–MS (LC-MS), produced...
Abstract Human GWAS have shown that obesogenic FTO polymorphisms correlate with lean mass, but the mechanisms remained unclear. It is counterintuitive because mass inversely correlated obesity and metabolic diseases. Here, we use CRISPR to knock-in rs9939609-A into hESC-derived tissue models, elucidate potentially hidden roles of during development. We find among human tissues, most robustly affect muscle progenitors’ proliferation, differentiation, senescence, thereby accelerating...
During ageing, adult stem cells' regenerative properties decline, as they undergo replicative senescence and lose both their proliferative differentiation capacities. In contrast, embryonic foetal progenitors typically possess heightened capacities manifest a more robust response upon injury transplantation, despite undergoing many rounds of mitosis. How delay maintain after numerous mitosis, remains unknown. It is also unclear if defined factors can rejuvenate to confer extended capacities,...
Abstract It is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise acute injury are both known to induce regeneration, the molecular signals help trigger have remained unclear. Here, mass spectrometry imaging (MSI) used show injured a specific subset of prostanoids during including PGG1, PGD2, prostacyclin PGI2. The spike in promotes skeletal via myoblasts, aging. Mechanistically, PPAR γ /PGC1a signaling, which...
Abstract The well-conserved correlation between juvenility and tissue regeneration was first discussed by Charles Darwin. Ectopic Lin28 is known to play an important role in somatic reprogramming regeneration, but endogenous Lin28’s homeostasis had remained unclear. Through lineage tracing, we found that a rare subset of muscle stem cells (MuSCs) expressing Lin28a can respond acute injury proliferating as Pax3+ or Pax7+ MuSCs, contribute all types myofibers during regeneration. Compared with...