A5101659251- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- Endometriosis Research and Treatment
- Immune cells in cancer
- Pregnancy and Medication Impact
Chongqing Medical University
2018-2024
Children's Hospital of Chongqing Medical University
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018-2023
Macrophages play a crucial role in shaping the immune state within tumor microenvironment (TME) and are often influenced by tumors to hinder antitumor immunity. However, underlying mechanisms still elusive. Here, we observed abnormal expression of complement 5a receptor (C5aR) human ovarian cancer (OC), identified high levels C5aR on tumor-associated macrophages (TAMs), which led polarization TAMs toward an immunosuppressive phenotype. knockout or inhibitor treatment restored TAM response...
Recurrent spontaneous abortion is associated with abnormal maternal tolerance to the semi-allogenic fetus, wherein Th17/Treg axis plays a crucial role. Adiponectin (APN) an adipocytokine that shown be novel negative T-cell regulator and induce immune tolerance. The CBA/J × DBA/2 mating was used as abortion-prone model investigate whether addition of recombinant adiponectin (rAPN) improves pregnancy outcome. Recombinant therapy reduced rate in model. It skewed ability serum cytokine...