To prospectively investigate the apparent diffusion coefficient (ADC) and choline levels measured at hydrogen 1 ((1)H) magnetic resonance (MR) spectroscopy, to monitor therapeutic responses of hepatocellular carcinoma (HCC) transcatheter arterial chemoembolization (TACE).Institutional review board approval was obtained, all patients control subjects provided informed consent. Histologically proved large HCCs (>3 cm in diameter) were evaluated 20 (16 men four women; mean age, 59 years; range,...

Abstract We propose a compartmental model to explain the signal enhancement curves following bolus injection of Gd‐DTPA. The incorporates vascular volume fraction contribution, and possibility having different transport constants between plasma extravascular components. A Walker 256 carcinoma grown in rat muscle was used demonstrate capability this model. Several types tissues were included measurements: normal, quickly enhanced, slowly necrotic tissues. Blood blood‐tissue permeability...

Abstract Purpose To investigate the value of in vivo proton magnetic resonance spectroscopy (MRS) assessment large focal hepatic lesions and to measure metabolite change hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) using 3.0‐T scanner. Materials Methods In this prospective study, 43 consecutive patients with (not less than 3 cm diameter) tumors eight normal volunteer were included. MRS addition uninvolved liver parenchyma was carried out a whole‐body...

Objective: Diffusion-weighted imaging (DWI) is usually performed before administration of intravenous contrast agents. Repetition DWI occasionally necessary after administration, but the effects material on and apparent diffusion coefficient (ADC) values in abdomen have not yet been fully examined. The purpose this work to assess whether gadolinium-based significantly affects ADC at focal hepatic lesions. Methods: results 3.0 T (Signa VH3; GE Medical Systems, Milwaukee, WI) were examined 20...

Background: Team-Based Learning (TBL), which is a student-centered instructional approach, has been applied in various health-related courses, but research on the effectiveness of TBL radiologic technology limited. More needed to examine within field as well study teachers' reflective practices for development TBL.Objectives: This examines students' learning and course instructors' during quality control activities diagnostic imaging.Design: employed an action approach with mixed-methods....

Chromium poisoning can cause renal failure and death. intoxication may be managed using L-ascorbic acid (vitamin C) therapy. However, the evidence supporting effectiveness of this treatment is insufficient, mechanism action has not been clarified in cells. In study, our results showed that optimal regimen therapy human epithelial proximal tubule cells, HK-2 was 30 μg/mL. Supplementation with μg/mL within 8 h chromium (K2Cr2O7, Cr6+) effective to inhibit tubular cell damage by blocking...

Abstract Chronic exposure to inorganic arsenic trioxide causes tumors of the skin, urinary bladder, lung, and liver. Several cancer initiators promoters have been shown alter cell–cell signaling by interference with gap junction intercellular communication (GJIC) and/or modulation cell adhesion molecules, such as connexin43 (Cx43), E‐cadherin, β‐catenin. The aim this study was determine whether disruption interactions occurs in liver epithelial cells after trioxide. WB‐F344 were treated...

Most patients with liver cirrhosis must undergo a series of clinical examinations, including ultrasound imaging, biopsy, and blood tests. However, the quantification by extracting significant features from T2-weighted magnetic resonance image (MRI) provides useful diagnostic information in Sixty-two subjects were randomly selected to participate this retrospective analysis assigned experimental control groups. The MRI was obtained them dynamic adjusted gray levels. extracted standard...

Journal Article RecX is Involved In the Switch between DNA Damage Response and Normal Metabolism in D. radiodurans Get access Duohong Sheng, Sheng * 1State Key Laboratory of Microbial Technology, Shandong University, 250100 Jinan, China; 2Institute Nuclear-Agricultural Sciences, Zhejiang 310029 Hangzhou, China *To whom correspondence should be addressed. Tel: +13-658612032, Fax: 086-531-88362928, E-mail: dhsheng@sdu.edu.cn Search for other works by this author on: Oxford Academic PubMed...

Abstract Purpose To evaluate the potential of a new lipophilic paramagnetic complex [Gd(Bz‐TTDA)] 2– [(4s)‐4‐benzyl‐3,6,10‐tri(carboxymethyl)‐3,6,10‐triazadodecandioic acid] designed for use as hepatobiliary MR contrast agent. Materials and Methods imaging studies normal hepatocellular carcinoma (HCC) rat models were performed using 1.5‐T scanner. Sequential multislice T1‐weighted turbo field echo (TFE) (TR/TE/flip angle: 15 msec/6.1 msec/25°) coronal images rats obtained before after...

BACKGROUND: Anesthesia may alter the cellular components contributing to magnetic resonance imaging (MRI) signal intensities. Developing awake animal models evaluate cerebral function has grown in importance. OBJECTIVE: To investigate a noninvasive strategy for dynamic MRI (dMRI) of rabbits during carbogen challenge. METHODS: A nonmetallic assistive device with self-adhering wrap secure procedure was developed head fixation rabbits. Multi-shot gradient echo echo-planar sequence applied dMRI...

Arterial embolism is a major cause of ischemic stroke. Currently, digital subtraction angiography (DSA) the gold standard in clinical arterial embolization examinations. However, it invasive and risky.This study aims to longitudinally assess progression carotid artery middle cerebral occlusion animal model (MCAO) using magnetic resonance imaging (MRI) techniques.Turbo spin echo (TSE), time flight (TOF-MRA) diffusion weighted (DWI) were used evaluate image characteristics tissues at 1, 2, 3,...

The aim of this study was to investigate the rat liver injury caused by radiation using contrast enhanced magnetic resonance imaging (MRI) at 3T. agent used Resovist, a kind commercialized superparamagnetic iron oxide (SPIO). SPIO particles can be macrophaged Kupffer cells after intravenous injection. make MR signal decrease because susceptibility effect. When has radiation, macrophage function decreases. Once malfunction, irradiated decreases less than normal administration. Therefore,...

Although computed tomography (CT) is a powerful diagnostic imaging modality for diagnosing vascular diseases, it some what risky to human health due the high radiation dosage. Thus, CT vendors have developed low dose (LDCT) aiming solve this problem. Nowadays, LDCT has gradually become main stream of examination.This study aimed assess feasibility LDCTAin an animal model and compare features doses in two clinical scanners.Twenty-two New Zealand rabbit head neck CTA images pre- post-contrast...

Magnetic Resonance Imaging (MRI) has been one of the most revolutionary medical imaging modalities in past three decades. It recognized as a potential technique clinical diagnosis diseases well tumor differentiation. Alth

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used to diagnose cancer and monitor therapy. The maximum enhancement ratio (ERmax) obtained from the curve of signal intensity over time could be a biomarker distinguish normal tissue or benign tumors. We evaluated impact flip angle (FA) repetition (TR) on ERmax values dynamic gadobutrol-enhanced MR imaging, obtaining T1-weighted (T1W) VX2 tumors using 2-dimensional fast spoiled gradient echo (2D FSPGR) with various FAs...

Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) has been widely used in the diagnosis of lesions. Many contrast agents with various chemical and pharmacokinetic properties have developed for clinical use. The signal-to-noise ratio (SNR) contrast-to-noise (CNR) after agent administration depend on many factors, e.g. category injected dosage agents, field strength magnetic resonance (MR) scanner, slew rate gradient, type radiofrequency coil, reconstruction algorithm, pulse sequences, so...

Medical imaging plays a crucial role in modern medicine. In order to provide fast and accurate medical diagnosis, computed tomography (CT) is commonly used tool radiological examinations, 640-slice CT the most advanced modality.To evaluate radiation dose risk under abdominal examination.Examinations were performed using scanner on an Alderson-Rando anthropomorphic phantom. The scanning acquisition parameters same as those examination without contrast medium injection clinical practice. To...

Relaxivity is a very important indicator to evaluate the signal enhancement caused by MRI contrast agents. Many factors can affect relaxivity values. The aim of this study investigate influence factor TE in curve-fitting equation for T 1 measurements. A spin echo pulse sequence was used as scanning method. Gd -DTPA doped saline at 1.5 MR scanner under investigation. most widely agent nowadays. In study, both computer simulations and phantom studies were performed. values calculated using...

The incidence rate of capsular contracture after breast implant is about 8% to 12%. Patients would feel extremely uncomfortable scar formation. Administering oral medications (such as vitamin E and Zafirlukast tablets, etc.) or invasive capsulectomy surgery was commonly used for repair in clinical therapy. However, the therapeutic effect still under investigation. Shock waves can be remove soft connective tissue applications. It has been widely orthopedics rehabilitation. No related research...

The aim of this study was to evaluate the effect contrast agent gadobutrol on magnetic resonance diffusion-weighted imaging (MR DWI). Gadobutrol has higher relaxivity than Gd-DTPA and it also formulation 1.0 M 0.5 M. VX2 tumor implanted left thigh each New Zealand rabbit used as animal model. MR scanning performed using a 1.5 T clinical whole-body scanner with an 8-channel knee coil. results showed that there were significant differences in signal-to-noise ratio (SNR) apparent diffusion...