A5100321458- Respiratory viral infections research
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Inflammasome and immune disorders
- Asthma and respiratory diseases
- Sphingolipid Metabolism and Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Metabolomics and Mass Spectrometry Studies
- Immune cells in cancer
- Synthesis and biological activity
- Influenza Virus Research Studies
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Analysis
- Reproductive System and Pregnancy
- Pediatric health and respiratory diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tryptophan and brain disorders
- Medicinal Plants and Bioactive Compounds
- Cancer therapeutics and mechanisms
- NF-κB Signaling Pathways
- Liver Disease Diagnosis and Treatment
Shandong Academy of Pharmaceutical Sciences
2023-2025
Southwest Medical University
2011-2025
Jilin University
2016-2025
Peking Union Medical College Hospital
2012-2025
Capital Medical University
2017-2025
Affiliated Hospital of Hebei University
2016-2025
University of Electronic Science and Technology of China
2023-2025
Beijing Chest Hospital
2025
Guizhou Institute of Technology
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Abstract The INDUCER OF CBF EXPRESSION (ICE)–C-REPEAT BINDING FACTOR/DRE FACTOR1 (CBF/DREB1) transcriptional pathway plays a critical role in modulating cold stress responses Arabidopsis thaliana. Dissecting crucial upstream regulatory signals or components of the ICE-CBF/DREB1 cascade will enhance our understanding plant cold-tolerance mechanisms. Here, we show that jasmonate positively regulates to freezing Arabidopsis. Exogenous application significantly enhanced tolerance with without...
Endoplasmic reticulum (ER) stress promotes tumor cell escape from immunosurveillance. However, the underlying mechanisms remain unknown. We hypothesized that ER induces hepatocellular carcinoma (HCC) cells to release exosomes, which attenuate antitumor immunity by modulating expression of programmed death ligand 1 (PD-L1) in macrophages. In this study, we demonstrated several markers (glucose-regulated protein 78, activating transcription factor 6, kinase R-like kinase, and...
Hepatocellular carcinoma (HCC) is a common and deadly cancer. Most cases of HCC arise in cirrhotic/fibrotic liver, indicating that environment may play paramount role cancer genesis. Previous studies from our group others have shown that, desmoplastic cancers, there rich intercellular communication between activated, cancer‐associated fibroblasts cells. Moreover, extracellular vesicles (EVs), or exosomes, been identified as an important arm this platform. Finally, these EVs can carry...
Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically increases with advancing age in men. However, the molecular mechanisms by which aging predisposes individuals to AAAs remain unknown.In this study, we investigated role SIRT1 (Sirtuin 1), class III histone deacetylase, formation and underlying linking senescence inflammation.The expression activity were significantly...
Extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have exhibited regenerative capability in animal models of ischemia-reperfusion (I/R) acute kidney injury (AKI) and are considered as potential alternatives to direct MSC therapy. However, real-time vivo imaging MSC-EVs renal I/R has yet be established. Renal intracellular targets responsible for their effects also remain elusive. Here, we report that observed specifically accumulated the injured were taken up proximal...
Approximately 8-9% of the world's population is affected by autoimmune diseases, and yet mechanism autoimmunity trigger largely understudied. Two unique cell death modalities, ferroptosis pyroptosis, provide a new perspective on mechanisms leading to development treatment strategies.Using scRNA-seq datasets, aberrant trend pyroptosis-related genes were analyzed in several representative diseases (psoriasis, atopic dermatitis, vitiligo, multiple sclerosis, systemic sclerosis-associated...
Sphingosine 1-phosphate (SPP) has been shown to inhibit chemotaxis of a variety cells, in some cases through intracellular actions, while others receptor-mediated effects. Surprisingly, we found that low concentrations SPP (10-100 nM) increased HEK293 cells overexpressing the G protein-coupled receptor EDG-1. In agreement with previous findings human breast cancer (Wang, F., Nohara, K., Olivera, O., Thompson, E. W., and Spiegel, S. (1999) Exp. Cell Res. 247, 17-28), SPP, at micromolar...
T cell-invigorating cancer immunotherapies have near-curative potential. However, their clinical benefit is currently limited, as only a fraction of patients respond, suggesting that these regimens may from combination with tumor-targeting treatments. As oncogenic progression accompanied by alterations in metabolic pathways, tumors often become heavily reliant on antioxidant machinery and be susceptible to increases oxidative stress. The cystine-glutamate antiporter xCT frequently...
Amygdalin, a naturally occurring substance, has been suggested to be efficacious as an anticancer substance. The effect of amygdalin on cervical cancer cells never studied. In this study, we found that the viability human HeLa cell line was significantly inhibited by amygdalin. 4,6-Diamino-2-phenyl indole (DAPI) staining showed amygdalin-treated developed typical apoptotic changes. development apoptosis in were confirmed double with annexin V-FITC and propidium iodide (PI) along increase...
Abstract Background Epidermal growth factor receptor (EGFR)-mutated lung cancer constitutes a major subgroup of non-small cell (NSCLC) and osimertinib is administrated as first-line treatment. However, most patients with treatment eventually relapse within one year. The underlying mechanisms resistance remain largely unexplored. Methods Exosomes isolation was performed by differential centrifugation. Co-culture assays were conducted to explore the alteration drug sensitivity viability...
In this paper, a series of novel 4-substituted coumarin derivatives were synthesized. Among these compounds 34, 39, 40, 43, 62, 65, and 67 exhibited significant antiproliferative activity toward panel tumor cell lines at subnanomolar IC50 values. Compound 65 showed potent ability (IC50 values 7-47 nM) retained full in multidrug resistant cancer cells. caused G2/M phase arrest interacted with the colchicine-binding site tubulin, as confirmed by immune-fluorescence staining, microtubule...
Abstract Background Gut microbiota (GM) of patients with liver cancer is disordered, and syet no study reported the GM distribution cirrhosis‐induced HCC (LC‐HCC) nonliver (NLC‐HCC). In this study, we aimed to characterize gut dysbiosis LC‐HCC NLC‐HCC elucidate role in pathogenesis HCC. Methods A consecutive series fecal samples hepatitis (24 patients), cirrhosis (75 patients: 35 infected by HBV, 25 HCV, 15 alcoholic disease), healthy controls (20 patients) were obtained sequenced on...
Abstract Background Severe, steroid-resistant asthma (SSRA) is a serious clinical problem in management. Affected patients have severe symptoms, worsened quality of life, and do not respond to steroid, mainstay steroid treatment asthma. Thus, effective therapies are urgently needed. Exosomes derived from mesenchymal stem cell (MSC-Exo) has become attractive candidates for the lung inflammatory diseases through its immunomodulatory effects. In this study, we explored therapeutic effects...
Rationale: Myocardial infarction (MI) is one of the most dangerous adverse cardiovascular events. Our previous study found that lysophosphatidic acid (LPA) increased in human peripheral blood after MI, and LPA has a protective effect on survival proliferation various cell types. However, role its receptors MI less understood. Objectives: To unknown heart during MI. Methods Results: In this study, we mice also had elevated level blood, as well cardiac expression receptor 2 early stages With...