A5080386307- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Mesenchymal stem cell research
- Ginseng Biological Effects and Applications
- Neuroscience and Neural Engineering
- Electrospun Nanofibers in Biomedical Applications
- Autoimmune and Inflammatory Disorders Research
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- Rheumatoid Arthritis Research and Therapies
- Tissue Engineering and Regenerative Medicine
- Caveolin-1 and cellular processes
- Traditional Chinese Medicine Studies
- S100 Proteins and Annexins
- Nuclear Structure and Function
- Cholinesterase and Neurodegenerative Diseases
- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Adenosine and Purinergic Signaling
- Eicosanoids and Hypertension Pharmacology
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
Beijing Friendship Hospital
2025
Capital Medical University
2025
Beijing Municipal Education Commission
2025
Jiangnan University
2025
Yantai University
2013-2024
Kunming University of Science and Technology
2024
First Affiliated Hospital of Xi'an Jiaotong University
2007-2024
Queen's University
2019-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Jiangxi Provincial People's Hospital
2024
Extracellular vesicles (EVs) released by mesenchymal stem cells (MSCs) have exhibited regenerative capability in animal models of ischemia-reperfusion (I/R) acute kidney injury (AKI) and are considered as potential alternatives to direct MSC therapy. However, real-time vivo imaging MSC-EVs renal I/R has yet be established. Renal intracellular targets responsible for their effects also remain elusive. Here, we report that observed specifically accumulated the injured were taken up proximal...
The commercial drug paclitaxel (Taxol) may introduce hypersensitivity reactions associated with the polyethoxylated castor oil-ethanol solvent. To overcome these problems, we developed a oil-free, liposome-based alternative formulation, known as Lipusu. In this study, performed in vitro and vivo experiments to compare safety profiles of Lipusu Taxol, special regard reactions. First, Swiss mice were used determine lethal dosages, then evaluate reactions, followed by histopathological...
// Hua-Ying Fan 1, * , Dong Qi 2, Chen Yu 3, Feng Zhao Tao Liu 4 Zuo-Kai Zhang 1 Ming-Yan Yang Lei-Ming Da-Quan Yuan Du School of Pharmacy, Key Laboratory Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry Education, Collaborative Innovation Center Advanced Delivery System Biotech Drugs in Universities Shandong, Yantai University, Yantai, P.R. China 2 Department Nephrology, Yu-Huang-Ding Hospital/Qingdao 3 Binzhou Medical for Reproductive Medicine, Tai'an Central...
// Leiming Zhang 1, * , Maojing Zhu Minmin Li Yuan Du 1 Sijin Duan Yanan Huang Yongying Lu Jianqiao Tian Wang and Fenghua Fu School of Pharmacy, Key Laboratory Molecular Pharmacology Drug Evaluation (Yantai University), Ministry Education, Collaborative Innovation Center Advanced Delivery System Biotech Drugs in Universities Shandong, Yantai University, Yantai, P.R. China These authors contributed equally to this work Correspondence to: Zhang, email: zhangleiming2009@126.com Fu,...
Hematopoietic stem cell (HSC)-independent lymphopoiesis has been elucidated in murine embryos. However, our understanding regarding human embryonic counterparts remains limited. Here, we demonstrated the presence of yolk sac-derived lymphoid-biased progenitors (YSLPs) expressing CD34, IL7R, LTB, and IRF8 at Carnegie stage 10, much earlier than first HSC emergence. The number lymphopoietic potential these were both significantly higher sac embryo proper this early stage. Importantly,...
Aberrant proliferation and inflammation of fibroblast-like synoviocytes (FLSs) significantly contribute to the pathogenesis rheumatoid arthritis (RA). Deficiency hydrogen sulfide (H2S) is a driving force for development RA, short half-life H2S-releasing donor sodium hydrosulfide (NaHS) limits its clinical application in RA therapy. Designing targeted delivery system with slow-release properties FLSs could offer novel strategies treating RA. Herein, we designed strategy achieve slow release...
Recent studies reported slowed conduction velocity (CV) in murine hearts homozygous for the gain-of-function RyR2-P2328S mutation (RyR2S/S) and associated this with an increased incidence of atrial ventricular arrhythmias. The present experiments determined mechanisms contributing to reduced CV. determinants CV were investigated RyR2S/S compared those wild-type (WT) slow-conducting Scn5a+/− hearts. Picrosirius red staining demonstrated fibrosis only Immunoblot assays showed similar...
Reductions in voltage-gated sodium channel (Nav1.5) function/expression provide a slowed-conduction substrate for cardiac arrhythmias. Nedd4-2, which is activated by calcium, post-translationally modulates Nav1.5. We aim to investigate whether elevated intracellular calcium ([Ca2+ ]i ) reduces Nav1.5 through Nedd4-2 and its role heart failure (HF).Using combination of biochemical, electrophysiological, cellular vivo methods, we tested the effect mechanism on turn Nav1.5.Increased [Ca2+ ,...
The present study aimed to investigate the effects of oral administration escin on acute inflammation and intestinal mucosal injury in animal models. carrageenan-induced paw edema a rat model inflammation, cecal ligation puncture (CLP) induced mouse model, were observed. It was shown that inhibits decreases production prostaglandin E2 (PGE2) cyclooxygenase- (COX-) 2. In CLP low dose ameliorates endotoxin liver increases expression tight junction protein claudin-5 mice. These findings suggest...
Rheumatoid arthritis (RA) is characterized by chronic progressive symmetrical synovitis and destruction of multiple joints. Glucocorticoids (GCs) are widely used in the treatment RA. However, their adverse effects can be serious. Escin, which isolated from Aesculus hippocastanum L., has been reported to have anti-inflammatory effects. We investigated anti-RA effect Escin combined with low dose GCs (dexamethasone, Dex) underlying mechanism. Adjuvant-induced RA rats lipopolysaccharides...
Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that has seriously affected human health worldwide and its current management requires more successful therapeutic approaches. The combination of nanomedicines pathophysiology into one system may provide alternative strategy for precise RA treatment. In this work, a practical ROS-mediated liposome, abbreviated as Dex@FA-ROS-Lips comprised synthetic dimeric thioether lipids (di-S-PC) surface functionalized with folic acid (FA),...