A5100402685- Inhalation and Respiratory Drug Delivery
- Lung Cancer Treatments and Mutations
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Lung Cancer Research Studies
- Drug Solubulity and Delivery Systems
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Crystallization and Solubility Studies
- HER2/EGFR in Cancer Research
- Advanced Photocatalysis Techniques
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microencapsulation and Drying Processes
- TiO2 Photocatalysis and Solar Cells
- Ferroptosis and cancer prognosis
- Aerogels and thermal insulation
- Chronic Lymphocytic Leukemia Research
- Biological Stains and Phytochemicals
First Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Yantai University
2016-2024
Shanghai Customs College
2024
Southwest University
2023
Yuhuangding Hospital
2023
Hainan Medical University
2021-2022
Affiliated Hospital of Southwest Medical University
2022
Queen Elizabeth Hospital
2021
The University of Adelaide
2021
Sustainable and safe delivery of brain-targeted drugs is highly important for successful therapy in Parkinson's disease (PD). This study was designed to formulate biodegradable poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles (NPs), which were surface-modified with lactoferrin (Lf), efficient intranasal rotigotine the brain treatment PD. Rotigotine NPs prepared by nanoprecipitation, effect various independent process variables on resulting properties investigated...
Glioblastoma is the most common malignant brain tumor. Efficient delivery of drugs targeting glioblastomas remains a challenge. Ephrin type-A receptor 3 (EPHA3) tyrosine kinase antibody-modified polylactide-co-glycolide (PLGA) nanoparticles (NPs) were developed to target glioblastoma via nose-to-brain delivery. Anti-EPHA3-modified, TBE-loaded NPs prepared using an emulsion-solvent evaporation method, showed sustained in vitro release profile up 48 h and mean particle size 145.9 ± 8.7 nm. The...
The aim of the present study was to examine whether erastin influences radioresistance in non-small cell lung cancer (NSCLC) cells and produce a preliminary investigation into its mechanism action. radioresistant subtype NSCLC cells, A549-R H460-R, were induced by high-dose hypofractionated irradiation. Erastin used treat radiosensitivity examined colony formation assays. Cell death determined after treated with erastin, irradiation (IR) or together IR. expression glutathione peroxidase 4...
Hot-melt extrusion technology has been widely reported for producing amorphous solid dispersions of poorly water-soluble compounds. A number studies revealed that enteric polymers containing ionizable groups are able to improve the physical stability and maintain drug supersaturation, thereby enhancing oral bioavailability. However, our previous found itraconazole (ITZ)-enteric polymer hydrophobic wettable. Moreover, release in an acidic environment (i.e. stomach) is very limited, indicating...
The severe functional impairment and poor prognosis of early-onset schizophrenia (EOS) create a great need to identify effective biomarkers for early diagnosis in young psychiatric patients. Current research indicates potential link between loss autophagy function emotional behavioral abnormalities individuals with disorders. This study aimed explore diagnostic autophagy-related endogenous competitive RNA (ceRNA) networks EOS messenger RNAs (mRNAs) long non-coding (lncRNAs) expression...
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by progressive and irreversible loss of function. Clinically safe efficacious drug treatments for IPF are lacking. Pirfenidone (an anti-inflammatory, antioxidant anti-fibrotic small-molecule drug) considered a promising treatment IPF. Unfortunately, several disadvantages pirfenidone caused traditional administration (e.g., gastrointestinal reactions, short elimination half-life) hinder its implementation. We...
Morphology tunable and acid-sensitive dextran–doxorubicin conjugate assemblies (DD-M DDF-V) were developed for targeted cancer therapy.
Thrombocytopenia is a thrombopoietin (TPO)-related disorder with very limited treatment options, and can be lifethreatening. There are major problems typical thrombopoietic agents targeting TPO signaling, so it urgent to discover novel TPO-independent mechanism involving thrombopoiesis potential druggable targets. We developed drug screening model by the multi-grained cascade forest (gcForest) algorithm found that 3,8-di-O-methylellagic acid 2- O-glucoside (DMAG) (10, 20 40 μM) promoted...
The role of KRAS mutation in non-small cell lung cancer (NSCLC) initiation and progression is well-established. However, "undruggable" protein poses the research small molecule inhibitors a significant challenge. Addressing this, proteolysis-targeting chimeras (PROTACs) have become cutting-edge treatment method, emphasizing degradation. A modified ethanol injection method was employed this study to formulate liposomes encapsulating PROTAC drug LC-2 (LC-2 LPs). Precise surface modifications...
Abstract As biomarkers, endogenous neurotransmitters play critical roles in the process of neuropsychiatric diseases, and neurotransmitter levels different brain regions can contribute to neurological disease diagnosis treatment. Due lack a blank matrix for neurotransmitters, surrogate‐matrix surrogate‐analyte approaches have been used determination solve this problem. In study, we capitalised on high accuracy, precision, throughput UHPLC‐MS/MS developed new methods based two approaches....
Aims: A simple and highly sensitive LC-MS method was used to determine the concentrations of losartan, its major active metabolite E3174 hydrochlorothiazide in human plasma pharmacokinetic characteristics metabolism phenotype observation after administration losartan tablets losartan/hydrochlorothiazide combination tablets. Methods: An open, randomized cross-over single-dose study designed forty healthy male volunteers, 50 mg or losartan/12.5 orally given blood samples were collected at...