A5101498499- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Plant-based Medicinal Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Adrenal and Paraganglionic Tumors
- Anesthesia and Sedative Agents
- Systemic Lupus Erythematosus Research
- Mechanical Circulatory Support Devices
- Angiogenesis and VEGF in Cancer
- Cardiac and Coronary Surgery Techniques
- Inflammatory Myopathies and Dermatomyositis
- Intensive Care Unit Cognitive Disorders
- Pulmonary Hypertension Research and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- PI3K/AKT/mTOR signaling in cancer
- Muscle and Compartmental Disorders
- CAR-T cell therapy research
- Cardiovascular Health and Disease Prevention
- Glycosylation and Glycoproteins Research
- Blood transfusion and management
Sichuan University
2022-2025
West China Hospital of Sichuan University
2025
Ethics and Public Policy Center
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Beijing Children’s Hospital
2014-2024
Capital Medical University
2008-2024
Southwest Medical University
2019-2022
State Key Laboratory of Oral Diseases
2022
Chengdu University of Traditional Chinese Medicine
2022
Chengdu Fifth People's Hospital
2022
Background Delirium is a frequent complication after cardiac surgery and its occurrence associated with poor outcomes. The purpose of this study was to investigate the impact perioperative dexmedetomidine administration on incidence delirium in elderly patients surgery. Methods This randomized, double-blinded, placebo-controlled trial conducted two tertiary hospitals Beijing between December 1, 2014 July 19, 2015. Eligible were randomized into groups. Dexmedetomidine (DEX) administered...
Leukopenia is the most common hallmark of hematopoietic diseases in clinic. Sanguisorba Officinalis L., a traditional Chinese medicine, has long been used for alleviating leukopenia. However, its associated mechanism still remains unknown. In this study, network pharmacology approach was to elucidate underlying mechanisms L. against Firstly, 12 active compounds were identified through TCMSP database with absorption, distribution, metabolism, excretion (ADME) screening, and UHPLC-MS analysis....
Background and objective Extreme haemodilution occurring with cardiopulmonary bypass imposes a primary risk factor for blood transfusion in small adult cardiac surgical patients. Priming of the circuit patients' own [retrograde autologous priming (RAP)] is technique used to limit reduce requirements. We designed this study evaluate effects RAP on reducing perioperative adults. Methods One hundred twenty patients body surface area less than 1.5 m2 undergoing first-time, nonemergency surgery...
Perioperative dexmedetomidine is reported to reduce complications and even in-hospital mortality after cardiac surgery. We therefore tested the hypothesis that perioperative may improve long-term outcomes This was follow-up of a randomized trial. enrolled 285 patients aged 60 years or older who were scheduled for elective Patients receive either placebo (normal saline) during early Follow-up conducted up 6 post-surgery. The primary endpoint overall survival. Secondary included major adverse...
Department of Anesthesiology and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University, Province, Chengdu 610041, Funding: The authors have no sources funding to declare this manuscript Contributors: All contributed writing the article. Patient consent publication: Written informed was obtained from patients publication report. Ethics approval: Not applicable. Conflicts Interest: conflicts interest. Reprints: Jing Yang, MD, PhD, Anesthesiology, Hospital,...
Previous studies have demonstrated that tannin could inhibit the proliferation and angiogenesis of cancer cells. However, mechanism(s) associated with its antitumor effect remains unclear. Here, we investigated effects 3,3',4'-trimethylellagic acid (TMEA), a compound isolated from Sanguisorba officinalis L., on proliferation, angiogenesis, apoptosis in cells, as well underlying related to activity. TMEA was L. by silica gel column chromatography. Molecular docking carried out assess active...
To examine if patients with PM/DM are at higher risk of complicated pregnancies.In a retrospective cohort in large tertiary centre North China, the outcomes 144 pregnancies were evaluated 62 women PM/DM. Generalized linear mixed effect models fitted to assess pregnancy occurring after disease on including preterm birth (PTB), abortion (spontaneous or induced) and normal delivery. Adjustment for confounding factors parity, maternal age pregnancy-disease interval achieved multivariable...
Thrombocytopenia is a thrombopoietin (TPO)-related disorder with very limited treatment options, and can be lifethreatening. There are major problems typical thrombopoietic agents targeting TPO signaling, so it urgent to discover novel TPO-independent mechanism involving thrombopoiesis potential druggable targets. We developed drug screening model by the multi-grained cascade forest (gcForest) algorithm found that 3,8-di-O-methylellagic acid 2- O-glucoside (DMAG) (10, 20 40 μM) promoted...
The profiling of natural products is important in modern biological sciences and new drug development. However, the separation characterization complex herbal extracts are significantly challenging for researchers biochemical field. Herein, an offline two-dimensional mixed-mode liquid chromatography × reversed-phase system developed. Our exhibits high orthogonality composed a newly prepared stationary phase first dimension traditional C18 second dimension, operated combination with...
Objective. To evaluate the impact of RA on work capacity and identify factors related to impairment in patients with RA.
Thrombocytopenia is closely linked with hemorrhagic diseases, for which induction of thrombopoiesis shows promise as an effective treatment. Polyphenols widely exist in plants and manifest antioxidation antitumour activities. In this study, we investigated the thrombopoietic effect mechanism 3,3′,4′-trimethylellagic acid (TMEA, a polyphenol Sanguisorba officinalis L.) using silico prediction experimental validation. A KEGG analysis indicated that PI3K/Akt signalling functioned crucial...
To assess relationships between carotid artery atherosclerosis and retinal arteriolar venular diameters.The community-based longitudinal Asymptomatic Polyvascular Abnormalities Community Study (APAC) included a sub-population of the Kailuan study which consisted 101,510 employees retirees coal mining industry. Based on Chinese National Census 2010 excluding individuals with history cerebrovascular ischemic events, 4004 were into APAC. All participants underwent detailed clinical examination...
To explore the therapeutic response (TR) and long-term outcomes of iodine-131 (I-131) treatment for patients with differentiated thyroid cancer pulmonary metastases (DTC+PM), as well association between assessment TR outcomes.This retrospective study comprised 151 DTC+PM patients. was evaluated by changes in serum levels thyroglobulin, anatomic imaging iodine uptake nodules; logistic regression applied to identify predictors. Overall survival (OS) calculated using Kaplan-Meier method...
To investigate macular microvascular characteristics imaged by optical coherence tomography angiography in patients with uveal melanoma following conbercept injections after plaque radiotherapy.Prospective comparative analysis comprising 15 and 30 without radiotherapy angiography. The group received intravitreal at the time of removal, 1 month, 3 months, 6 months , 9 12 removal (total, injections). control had no injection.After initiation injections, superficial retinal vascular density...