A5101490831- Platelet Disorders and Treatments
- Supramolecular Self-Assembly in Materials
- Plant-based Medicinal Research
- Cholesterol and Lipid Metabolism
- Electron Spin Resonance Studies
- Natural product bioactivities and synthesis
- Gas Sensing Nanomaterials and Sensors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Polydiacetylene-based materials and applications
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Calcium signaling and nucleotide metabolism
- Analytical Chemistry and Sensors
- Advanced Thermodynamics and Statistical Mechanics
- Multiple Myeloma Research and Treatments
- Phytochemistry and Bioactive Compounds
- Angiogenesis and VEGF in Cancer
- Reinforcement Learning in Robotics
- Blood groups and transfusion
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Inflammasome and immune disorders
- Computational Drug Discovery Methods
- Mitochondrial Function and Pathology
Chengdu University of Traditional Chinese Medicine
2012-2025
Nankai University
2019
Hunan University of Technology
2019
National Center for Nanoscience and Technology
2011-2018
Henan Polytechnic University
2017
Soochow University
2011-2013
A facile strategy is reported for design and preparation of flexible micro-supercapacitors on a chip based patterned electrodes conducting polyaniline nanowire arrays. The interdigital microelectrode produced by combining microfabrication technology an in-situ chemical polymerization approach. assembled micro-supercapacitor showed superior volumetric capacitance, fast rate capability reduced leakage current using H2SO4- polyvinyl alcohol gel electrolytes.
Abstract A new symmetrical sugar‐based perylenediimide derivative PTCDI‐BAG is synthesized and its aggregate morphologies formation mechanisms are studied in detail the mixed solvent system water/ N,N ‐dimethylformamide (H 2 O/DMF) with changing volume ratios. molecules self‐assemble into planar ribbons 20/80 40/60 H O/DMF (v/v), but their chiralities opposite according to recorded circular dichroism (CD) spectra. With a further increase of water content, only left‐handed helical nanowires...
Chiral amplification and discrimination are great challenges in both scientific technological research fields such as chemical synthesis, chiral catalysis, biomedicine. By mimicking protein superstructures nature, conducting polyaniline (PANI) molecules induced by dopants were self-assembled to ultra-ordered superhelical microfibers. The homochirality is observed be amplified into different hierarchies, from helical nanostructures, microstructures. Furthermore, experimental theoretical...
Berberine (BBR) is widely used to treat gastrointestinal diseases. However, the pharmacological mechanism of action BBR in anti-chronic atrophic gastritis (CAG) remains unclear. This study aimed investigate CAG by integration molecular biology and multi-omics studies strategy. The model was established alternating drinking water 0.1% ammonia 20 mmol/L sodium deoxycholate, accompanied an irregular diet. Serum biochemical indices including PGI, PGII, GAS-17, IL-6, IL-1β, TNF-α were analyzed....
Ammonia sensory properties based on conductometric gas sensors composed of single-crystalline micro/nanostructures PTCDI-C12, PTCDI-Br2C12, and PTCDI-CN2C12 were investigated, it was found that the core-cyanated sensor response to NH3 gas. The initial sensitivity had a value 40%, then slightly decreased 37% in 24 h, could still keep stable after its exposure air for 14 days. Detailed studies indicated addition strong electron-withdrawing group, CN, caused significant decreasing reduction...
Leukopenia is the most common hallmark of hematopoietic diseases in clinic. Sanguisorba Officinalis L., a traditional Chinese medicine, has long been used for alleviating leukopenia. However, its associated mechanism still remains unknown. In this study, network pharmacology approach was to elucidate underlying mechanisms L. against Firstly, 12 active compounds were identified through TCMSP database with absorption, distribution, metabolism, excretion (ADME) screening, and UHPLC-MS analysis....
Abstract Higenamine (HG) is a natural benzylisoquinoline alkaloid isolated from Aconitum with positive inotropic and chronotropic effects. This study aimed to investigate the possible cardioprotective effects of HG combined [6]‐gingerol (HG/[6]‐GR) against DOX‐induced chronic heart failure (CHF) by comprehensive approaches. cardiotoxicity model in rats H9c2 cells was established. Therapeutic HG/[6]‐GR on haemodynamics, serum indices histopathology cardiac tissue were analysed. Cell...
Abstract Background Abnormal activation of NLRP3 inflammasome is related to a series inflammatory diseases, including type 2 diabetes, gouty arthritis, non-alcoholic steatohepatitis (NASH), and neurodegenerative disorders. Therefore, targeting regarded as potential therapeutic strategy for many diseases. A growing number studies have identified tanshinone I (Tan I) anti-inflammatory agent because its good activity. However, specific mechanism direct target are unclear need further study....
Transfer of molecular chirality to supramolecular at nanoscale and microscale by chemical self-assembly has been studied intensively for years. However, how such further transfers the macroscale along same path remains elusive. Here we reveal from level macroscopic via self-assembly. We assemble a macrostripe using enantiomeric camphorsulfonic acid (CSA)-doped polyaniline with hierarchical order. The stripe can twist into single-handed helical ribbon self-motion. A multi-scale...
Codelivery of chemotherapeutic drugs in nanoparticles can enhance the therapeutic effects against tumors. However, their anticancer properties and physiochemical characteristics be severely influenced by many formulation parameters during preparation process. It is a complicated development phase to select optimal for based on commonly used one single parameter method, which consumes lot money, time, effort, sometimes even fails. Therefore, statistical analysis Box-Behnken design (BBD) has...
Abstract Helical structures at different scales endow functional materials with special optical, electrical, and magnetic properties. However, methods for constructing regulating single‐handed helicity, particularly complex 3D hierarchical structures, remain limited. In this study, co‐self‐assembly process combined emulsion droplets is used to produce the various well‐defined hollow superstructures of conducting polyaniline (PANI) helicity. The chirality PANI induced using enantiomeric r ‐...
Using a bioassay-directed chromatographic separation, two ellagic acids were obtained from the ethyl acetate extract of roots Sanguisorba officinalis L. On basis chemical and spectroscopic methods, identified as 3,3',4-tri-O-methylellagic acid-4'-O-β-d-xyloside acid. Stimulation cell proliferation was assayed in hematopoietic progenitor cells using Cell Counting kit-8 method. The megakaryocyte differentiation determined human erythroleukemia (HEL) Giemsa staining flow cytometry analysis....
Doxorubicin (DOX) can induce myocardial energy metabolism disorder and further worsen heart failure. "Energy protection" is proposed as a new cardiac protection strategy. Previous studies have found that Di'ao Xinxuekang (DXXK) improve doxorubicin-induced cardiotoxicity in mice by inhibiting ferroptosis. However, there are very few associating DXXK protection. This study aims to explore the "energy effect of on induced DOX. A DOX-induced model established rats H9c2 cells used analyze...
Previous studies have demonstrated that tannin could inhibit the proliferation and angiogenesis of cancer cells. However, mechanism(s) associated with its antitumor effect remains unclear. Here, we investigated effects 3,3',4'-trimethylellagic acid (TMEA), a compound isolated from Sanguisorba officinalis L., on proliferation, angiogenesis, apoptosis in cells, as well underlying related to activity. TMEA was L. by silica gel column chromatography. Molecular docking carried out assess active...
Ulcerative colitis (UC) is a complex immune-mediated inflammatory disease. In recent years, the incidence of UC has increased rapidly, however, its exact etiology and mechanism are still unclear. Based on definite anti-inflammatory antibacterial activities Sanguisorba officinalis L., we studied monomer, methyl gallate (MG). this study, employed flow cytometry detected nitric oxide production, finding MG regulated macrophage polarization inhibited expression proinflammatory cytokines in...
Two core-tetrachlorinated perylenediimide derivatives PTCDI-ClC12 and PTCDI-ClC4F7 bearing electron-donor dodecyl electron-withdrawing fluorobutyl groups at the imide positions, respectively, were prepared. The determination of sensing properties based on their conductometric gas sensors revealed that both devices had same sensitivity to hydrazine vapor approximately 4 orders magnitude in resistance decreased upon exposure (10 ppm). Whereas 2 for another core-unsubstituted PTCDI-C12 sensor...
It is currently a challenge to accurately predict the deformation and fracture behavior of metal parts in automobile crashes. Many studies have shown that materials are significantly affected by stress state during crashes with complex characteristics. In order further promote application die-cast magnesium alloys automobiles, it particularly important study material alloys. this paper, mechanical properties AM60B alloy sheet under four states (shear, tension, R10 notch cupping) were...
Thrombocytopenia is a thrombopoietin (TPO)-related disorder with very limited treatment options, and can be lifethreatening. There are major problems typical thrombopoietic agents targeting TPO signaling, so it urgent to discover novel TPO-independent mechanism involving thrombopoiesis potential druggable targets. We developed drug screening model by the multi-grained cascade forest (gcForest) algorithm found that 3,8-di-O-methylellagic acid 2- O-glucoside (DMAG) (10, 20 40 μM) promoted...
Uniform patterning of polyaniline nanowire arrays on a wafer-sized flexible substrate is achieved by combining photolithography and in situ polymerization techniques. Chemical gas sensors based the patterned exhibit excellent performance because their highly ordered morphology large specific surface area.