A5100370390- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Metabolomics and Mass Spectrometry Studies
- Neurological Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Microbial Metabolism and Applications
- Cardiac electrophysiology and arrhythmias
- Barrier Structure and Function Studies
- Andrographolide Research and Applications
- Neuropeptides and Animal Physiology
- Liver physiology and pathology
- Microbial Inactivation Methods
- Advanced Chemical Sensor Technologies
- thermodynamics and calorimetric analyses
- Heart Failure Treatment and Management
- Ginger and Zingiberaceae research
- Peroxisome Proliferator-Activated Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Biochemical and biochemical processes
- Cancer, Stress, Anesthesia, and Immune Response
- Phytochemical Studies and Bioactivities
- Cancer, Hypoxia, and Metabolism
Chinese Center For Disease Control and Prevention
2025
Chinese People's Liberation Army
2025
Chengdu University of Traditional Chinese Medicine
2014-2023
Hospital for Sick Children
2023
Henan Polytechnic University
2022
Chinese PLA General Hospital
2020
Yunnan University of Traditional Chinese Medicine
2020
Guiyang Medical University
2020
Washington State University
2009
Plant & Food Research
1998
Abstract Higenamine (HG) is a natural benzylisoquinoline alkaloid isolated from Aconitum with positive inotropic and chronotropic effects. This study aimed to investigate the possible cardioprotective effects of HG combined [6]‐gingerol (HG/[6]‐GR) against DOX‐induced chronic heart failure (CHF) by comprehensive approaches. cardiotoxicity model in rats H9c2 cells was established. Therapeutic HG/[6]‐GR on haemodynamics, serum indices histopathology cardiac tissue were analysed. Cell...
Myocardial fibrosis following acute myocardial infarction (AMI) seriously affects the prognosis and survival rate of patients. This study explores role regulation mechanism storax, a commonly used traditional Chinese medicine for treatment cardiovascular diseases, on cardiac function. The AMI rat model was established by subcutaneous injection Isoproterenol hydrochloride (ISO). Storax (0.1, 0.2, 0.4 g/kg) administered gavage once/d 7 days. Electrocardiogram, echocardiography, hemodynamic...
This study was aimed to explore the mechanism of Aconiti Lateralis Radix Praeparata (ALRP) and Zingiberis Rhizoma (ZR) on doxorubicin (DOX)-induced chronic heart failure (CHF) in rats by integrated approaches.
This study was aimed to investigate the therapeutic effects and potential mechanism of higenamine combined with [6]-gingerol (HG/[6]-GR) against doxorubicin (DOX)-induced chronic heart failure (CHF) in rats.Therapeutic HG/[6]-GR on hemodynamics indices, serum biochemical indicators, histopathology TUNEL staining rats were assessed. Moreover, a UHPLC-Q-TOF/MS-based metabolic approach performed identify metabolites possible pathways DOX-induced CHF.HG/[6]-GR had regulating hemodynamic...
Background Heart transplantation with a donation after circulatory death (DCD) heart is complicated by substantial organ ischemia and ischemia-reperfusion injury. Exenatide, glucagon-like peptide-1 receptor agonist, manifests protection against cardiac injury in other settings. Here we evaluate the effects of exenatide on DCD hearts juvenile pigs. Methods Results 15-minutes global warm arrest were reperfused ex vivo switched to working mode. Treatment concentration 5-nmol was given during...
Astragali Radix (AR), the dried root of membranaceus (Fisch.) Bge. or var. mongholicus (Bge) Hsiao, is a commonly used traditional Chinese medicine for treatment liver diseases. This study aimed to comprehensively evaluate pharmacological action and explore potential mechanism AR on fibrosis. Rats were administered with carbon tetrachloride eight weeks, followed by oral six weeks. The efficacy was confirmed measuring function fibrosis levels. underlying mechanisms explored detecting...
This study aimed to elucidate the effect and underlying mechanism of Bovis Calculus in treatment ulcerative colitis(UC) through network pharmacological prediction animal experimental verification. Databases such as BATMAN-TCM were used mine potential targets against UC, pathway enrichment analysis was conducted. Seventy healthy C57BL/6J mice randomly divided into a blank group, model solvent model(2% polysorbate 80) salazosulfapyridine(SASP, 0.40 g·kg~(-1)) high-, medium-, low-dose...
Abstract Objectives This study aimed to investigate metabolic biomarker changes and related pathways before after treatment with l-borneolum in cerebral ischaemic rats. Methods Rats were subjected pMCAO surgery. The Zea-Longa scoring method was used evaluate neurological deficits. TTC staining observe infarction. HE the pathological brain tissue. metabolomics analyse metabolism. Results pharmacology of H-B group significantly different from those vehicle group. Moreover, according method,...